DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and adcy3a

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_009290286.1	Gene:	adcy3a / 571825	ZFINID:	ZDB-GENE-111027-6	Length:	1119	Species:	Danio rerio

Alignment Length:	751	Identity:	162/751 - (21%)
Similarity:	280/751 - (37%)	Gaps:	233/751 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SNRPMESRTAPDDVNPSGEGG--------------LLLVPT----HHNLQLDKISVRSISSEDIS 85
            |...:|......||.| |.||              |:::|.    .:.:...|:||.|      |
Zfish   457 SQNTLECLHGEFDVEP-GNGGDRCEYLKERGIETYLVVLPKGPVGKNGINGVKLSVTS------S 514

  Fly    86 NGGSGRCCNAAARNPAIKTGRRL-----QLMQMIILPFIPILALIVQTSVTLQEILEYRSAVADI 145
            ||.|....|....|.::.|....     :|...::.|..|    ..:..:.|:::.|   .|.|.
Zfish   515 NGNSPLLINTTECNGSVHTACTTPEDPEELDTRVVNPSFP----NPRRRLRLRDLAE---RVIDA 572

  Fly   146 ETQVTIATDLGKVVTRLQLERSEVAFY--IFTNGSKQRANLTLRFANTDHALNNMTTWSEISVPT 208
            :..   ..:|.|::....|||..|...  .:||      .|:|||                   |
Zfish   573 QEN---EQELNKLLNEALLERETVQALKGKYTN------RLSLRF-------------------T 609

  Fly   209 APDEDEDDREMMLNRYEFQSRLNEFRDRVRLEPEESS------------ITEVMN-----W---- 252
            .|                     |...|..:|.|:.|            .|.||.     |
Zfish   610 DP---------------------ELETRFSVEKEKQSGAAFSCSCVVLLFTAVMEALIDPWLVAN 653

  Fly   253 YTSINRG----------------------LLHHLSEQIKETD-NSGVWR----YLVGFKNLLKSI 290
            |.::..|                      .|...|..|..|. ....|.    ::|...:::..:
Zfish   654 YVTLAVGEVLLLILTICSLAAIFPRVFPKRLVSFSTWIDHTRWARNTWAMAAIFIVTLADIVDML 718

  Fly   291 ECQNIATSFGIRYYGRGSLTAEN-----FVSYVR--------YEFMAREMINSTLNYAPMLKNMY 342
            .|:...||           |.|:     .|:.:|        |.|:|...:.:|        .|.
Zfish   719 SCRAPQTS-----------TVESTAVPPVVTAIRGCAENPKYYSFIAVLALIAT--------TML 764

  Fly   343 TNITSTKKFHRAK---QMGTTLLKNNPNVSNERSAIEYYELMNNYTDDLRILQKALRRLIKEYVD 404
            ..::     |..|   .:..|:.....|:.:.....:.|:|..                .||| .
Zfish   765 VQVS-----HMVKLTLMLLITVATGAVNIYSWSQTFDLYDLTR----------------FKEY-R 807

  Fly   405 KTLVEADRKEAIGIAILVVVLIVSPVIIVL-VKNAAATIQLYALNLSQKAKELKREKRKSDSLLF 468
            ..||.:    ...:::::.:::||...... |:..|.|:.|:.:.:.::.:::...:|.:::|:.
Zfish   808 VNLVPS----KYTMSVMIFIMMVSFYYFSRHVEKLARTLFLWKIEVHEQKEKVYEMRRWNEALVT 868

  Fly   469 QMLPPSVAMQL----KQTQQVPAELYEAVTIYFSDIVGF----TEIAADCTPLEVVTFLNSIYRV 525
            .|||..||...    |:.:::.::.|:.:.:.|:.|..|    ||.:.:...:|.:.|||.|...
Zfish   869 NMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIISD 933

  Fly   526 FDERIE-----CYDVYKVETIGDSYMVASGLPVKNGN-----------------KHISEIATMAL 568
            ||..::     |  :.|::|||.:||.|||:...|..                 :|::::|..||
Zfish   934 FDSLLDEPQFRC--ITKIKTIGSTYMAASGVTSDNNTNGYACMKKEEISDRERWQHLADLADFAL 996

  Fly   569 DLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIH 633
            .:  ..::..|.........:|.|::.|.|:||::|.:.|.:.::|:|||.||||||||....|.
Zfish   997 AM--KVTLMNINYQSFNNFMLRIGLNKGAVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQ 1059

  Fly   634 ITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWL 669
            :.|:.:..|:.. |||...||.|.|||||.:.||:|
Zfish  1060 VVEDCYCILKDY-GFRFVRRGPIFVKGKGELLTYFL 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	47/302 (16%)
		HNOBA	<439..479	CDD:285003	10/39 (26%)
		CYCc	459..647	CDD:214485	60/217 (28%)
		Guanylate_cyc	485..669	CDD:278633	65/209 (31%)
adcy3a	XP_009290286.1	AC_N	<37..304	CDD:292831
		CYCc	273..468	CDD:214485	2/10 (20%)
		Guanylate_cyc	310..492	CDD:278633	8/35 (23%)
		CYCc	858..1075	CDD:214485	62/221 (28%)
		Guanylate_cyc	889..1096	CDD:278633	66/211 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900