DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and adcy7

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_021333246.1	Gene:	adcy7 / 568726	ZFINID:	ZDB-GENE-040713-1	Length:	1119	Species:	Danio rerio

Alignment Length:	686	Identity:	156/686 - (22%)
Similarity:	257/686 - (37%)	Gaps:	238/686 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 TNGSKQRANLTL-RFA------------------NTDHALNNMTTWSEI---SVPT-APDEDEDD 216
            ::|.|.||::.: ||.                  |||..:|......:|   |||| .||..::.
Zfish   475 SDGLKMRASVRMTRFLESWGAVKPFAHLQSREEFNTDAMVNGKGHCKDIPLRSVPTHNPDSFDES 539

  Fly   217 RE----------MMLNRYEFQSRL--NEFRDRVRLEPEESSITEVMNWYTSINRGLLHHLSEQIK 269
            .|          ...||.:.|...  .|..|::.               |:||.  |....:.:|
Zfish   540 LEEPFSLPAPPLSTYNRNKSQKTKFDEELHDKMT---------------TTIND--LSSSKQWVK 587

  Fly   270 ETDNSG--VWRYLVGFKNLLKSIECQNIATSFGIRYYGRGSLTAENFVSYVRYEFMAREMINSTL 332
            ..:.||  :|......:...::||..|      .:|| .|..|......::....:.::.|...|
Zfish   588 SEEISGLTLWFTKKDLEMQYRTIEMPN------FKYY-IGCATFIFICIFIIQMLVTKQRIELGL 645

  Fly   333 NYAPM---------------LKNMY-------------TNITSTKKFHR--AKQMGTTLLKNNPN 367
            .:|.:               ::.|:             :.....:.|.|  ...:.||::
Zfish   646 GFAVLACFLLLILCICFADHIQRMFPEKLKSCTWLLALSKAVVKRPFVRILLATVATTVI----- 705

  Fly   368 VSNERSAIEYYELMNNYTDDL-RILQKALRRLIKEYVDKTLVEADRKE----------------A 415
                 ..|..:||....||:| .:||:          :.:..::.|.|                |
Zfish   706 -----VVIAMFELFLKKTDNLCDLLQQ----------NSSFADSARDELQYLPYLVYNCILALIA 755

  Fly   416 IGI----------AILVVVLIVSPVIIV------------------------------LVKNAA- 439
            .|:          |.|::|.:||..||:                              |:|:..
Zfish   756 CGVFLRVSFELKLAFLLIVSLVSYTIILYSQENLFSNYNCLLYTNHSCGDSLMVCKAGLMKHPKI 820

  Fly   440 -----ATIQLYALNLSQKAKE-------LKREKRKSDS------------LLFQMLPPSVA---- 476
                 .|:.|:.:.|..:..|       |.:.|..:|.            ||..:||..||
Zfish   821 MSCIYITLFLFTMLLISRQNEYCCRQDFLLKNKNLADKEEVELCENLNRLLLENVLPAHVAALFV 885

  Fly   477 ---------------MQLKQTQQVPAELYEAVTIYFSDIVGFTEIAADC----TPLEVVTFLNSI 522
                           :..::.:.:..:.|:.|.:.|:.:..|.|...:|    ..||.:..||.|
Zfish   886 GENKKNEVGLLSAISLLNRKYKDLYYKSYDCVCVMFASVPDFKEFYTECDINKEGLECLRLLNEI 950

  Fly   523 YRVFDERI---ECYDVYKVETIGDSYMVASGL--PVKNGNK----------HISEIATMALDLLD 572
            ...|||.:   :...|.|::|||.:||.|:||  |.:..|:          ::.|.|...:..||
Zfish   951 IADFDELLSKPKFSGVEKIKTIGSTYMAAAGLSGPPEQSNQDRERQNAQIGNMVEFAIALIGKLD 1015

  Fly   573 ASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEE 637
            .     |.|......::|.|::.|||:||::|.:.|:|.::|:|||.|||||||||..||.:|||
Zfish  1016 G-----INRHSFNTFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEE 1075

  Fly   638 MHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWLTCKD 673
            ....||.: |:..|.||||:|||||.:.|::: |.|
Zfish  1076 TSIVLQNL-GYSCECRGLINVKGKGELKTFFV-CTD 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	54/288 (19%)
		HNOBA	<439..479	CDD:285003	13/83 (16%)
		CYCc	459..647	CDD:214485	70/237 (30%)
		Guanylate_cyc	485..669	CDD:278633	74/202 (37%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454
		Guanylate_cyc	272..455	CDD:306677
		DUF1053	487..613	CDD:310728	29/142 (20%)
		Guanylate_cyc	909..1106	CDD:306677	74/202 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900