DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and gucy2cb

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_021329920.1	Gene:	gucy2cb / 568219	ZFINID:	ZDB-GENE-130531-31	Length:	1071	Species:	Danio rerio

Alignment Length:	673	Identity:	201/673 - (29%)
Similarity:	313/673 - (46%)	Gaps:	106/673 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 GEGGLL--LVPTHHNLQLDKISVRSISSEDISNGGSGRCCNAAARNPAIKTGRRLQLMQMIILPF 118
            |:..|:  |:.|::|.|.:.:...:.|:.......|.......:|.|.....:.|.::::|::
Zfish   367 GDRDLMFSLIYTNNNNQYNILYQFNTSNNKTGLKDSSPSFIWQSRLPNDSPSKGLSVIEIIVI-- 429

  Fly   119 IPILALIVQTSVTLQEILEYRSAV--------ADIETQVTIATDLGK---VVTRLQLERSEVAFY 172
              :|..::....||..|..:::..        :.|.:|:....:|.:   :..:::.:.:|.:.|
Zfish   430 --VLCTVIGIMGTLAFIFYWQNRYYHHMQKRWSHISSQLITPLELNEWNMISLKIEEDSTENSTY 492

  Fly   173 IFTNGSKQRANLTLR-FANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSR---LNEF 233
            |.......:..:.|: |..||   .:.|....|.:.|....|..:........:|.:.   :.|:
Zfish   493 ILRRARYDKKIVILKEFRLTD---GSFTEKQRIELNTLLKIDYCNLTKFYGTVKFDNEYFGVFEY 554

  Fly   234 RDRVRLE---------PEESSITEVMNWYTSIN------RGLLH-HLSE-----QIKET----DN 273
            .:|..|.         |||:    .|:|...|:      :|:.: |.|.     ::|.|    ||
Zfish   555 GERGSLRYVLDDKISYPEET----FMDWQFKISVMYDIAKGMSYLHTSNIAVHGRLKSTNCVVDN 615

  Fly   274 SGVWRYL-VGFKNLLKSIECQNIATSFGIRYYG---RGSLTAENFVSYVRYEFMAREMINSTLNY 334
            ..|.:.. .||..::...|....|... :|..|   :|.:.:...:|   .|.|.|:.
Zfish   616 RMVVKIADFGFNTIVSPSEDLWTAPEH-LRKPGISQKGDVYSFAIIS---QEIMMRKC------- 669

  Fly   335 APMLKNMYTNITS--TKKFHRAKQMGTT-LLKNNPNV-SNERSAIEYYELMNNYTDDLRILQKAL 395
                 ..|||..|  .:|..|.:...|| ..:.:.|. |...|..|...|:.|..|:
Zfish   670 -----TFYTNTCSDRAEKLARVQYPSTTSFFRPDLNFESTSESEEEVCMLIRNCWDE-------- 721

  Fly   396 RRLIKEYVDKTLVEADRK---EAIGIAILVVVLIVSPVIIVLVKNAAATIQLYALNLSQKAKE-- 455
                         :.||:   :.|.||:..:|...:......::|....:|:|:.||.:..:|
Zfish   722 -------------DPDRRPDFKKIEIALWKIVSRDNQEHESYMENLIRRLQMYSRNLERLVEERT 773

  Fly   456 --LKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVVTF 518
              .|.|:.::|.|.|.:||..|...||:|.:|..||::.||||||||||||.:....||:|||..
Zfish   774 ALYKAERDRADCLNFMLLPGPVVRSLKETGKVEPELFDEVTIYFSDIVGFTTLCHFSTPMEVVDM 838

  Fly   519 LNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAG 583
            ||.||:.||..::.:||||||||||:|||.||||.:|||:|..:|..||||:|......::....
Zfish   839 LNDIYKNFDSILDNHDVYKVETIGDAYMVVSGLPRRNGNRHAKDICLMALDILAFMGTIQLSHLP 903

  Fly   584 DEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVG-G 647
            ...|.||.|||:||..||:||.||||||||||||||||||||||...:||:::...:.||:.. .
Zfish   904 GIPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSQSTINILQRTDCK 968

  Fly   648 FRTEHRGLIDVKGKGLMSTYWLT 670
            |..|.||...:||||...|||||
Zfish   969 FEYEERGETFLKGKGKEMTYWLT 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	55/273 (20%)
		HNOBA	<439..479	CDD:285003	13/43 (30%)
		CYCc	459..647	CDD:214485	101/188 (54%)
		Guanylate_cyc	485..669	CDD:278633	101/184 (55%)
gucy2cb	XP_021329920.1	Periplasmic_Binding_Protein_Type_1	33..408	CDD:324556	8/40 (20%)
		PKc_like	471..741	CDD:328722	61/313 (19%)
		CYCc	778..970	CDD:214485	101/191 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910