Protein Alignment CG33958 and adcy2a

DIOPT Version :10

• Sequence 1: NP_001033958.1
• Gene: CG33958 / 37088
• FlyBaseID: FBgn0053958
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: XP_692173.5
• Gene: adcy2a / 563724
• ZFINID: ZDB-GENE-061109-1
• Length: 1155
• Species: Danio rerio
• Alignment Length: 655
• Identity: 149/655 - (22%)
• Similarity: 263/655 - (40%)
• Gaps: 174/655 - (26%)

  Fly   158 VVTRL----QLERSEVAFYI----FTNGSKQRANLTLR-----------FANTDHALNNMTTWS- 202
            |:|.|    ::||.....|.    ..:|:|.||::.:.           |||..|. ::||..:
Zfish   517 VITYLVINPKVERKSPQHYYRPRHTIDGAKMRASVRMTRYLESWGAAKPFANLHHR-DSMTNENG 580

  Fly   203 EISVPTAPDEDEDDREMMLNRYEFQSRLNEFRDRVRLEPEE---------SSITEVMNWYTS--I 256
            :|:....|          :.:|.||.|....:.:.:...||         ..|.....|..|  |
Zfish   581 KINTADVP----------IGQYHFQRRSERTKSQKKRFEEELNERMIRTFDGINSQKQWLKSEDI 635

  Fly   257 NR-GLLHH---LSEQIKETDNSGVWRYL---------VGFKNLLKSIECQNIATSFGIRYYGRGS 308
            .| .|..|   |.::.:.|.......|:         :....:|...:...:..|||:.:.   .
Zfish   636 QRISLFFHNKALEKEYRATTLPAFKYYITCACLIFFCIFIVQILVLPKTAILGVSFGMSFL---I 697

  Fly   309 LTAENFVSYVRYEFMAREMINSTLNYAPMLKNMYTNITSTKKFHR-AKQMGT------------- 359
            |:....|.::.:....::  .::.::..:|::  :.|.::|.:.| ...|.|
Zfish   698 LSVILLVCFIGHFLQCKK--TASASWVWILRS--SGIIASKPWPRITLTMATTALILIMAVFNMF 758

  Fly   360 ------TLLKNNPNVSNER------SAIEYYE-----------------------LMNNYTDDLR 389
                  ||::...|.|||.      ..|.|.:                       |..||...:.
Zfish   759 FIEDNLTLMETVYNTSNETLLQPDGQPIPYLDKNTFYLPYFIYSCILGLISCSVFLRINYELKML 823

  Fly   390 ILQKAL-----------RRLIKEY---------VDKTLVEADRKEAIGIAILVVVLIVSPVIIVL 434
            |:..|:           ..|:.||         :::..|..|.|....:::.:..:    .::||
Zfish   824 IMLTAVVLYSVIILQTHASLLDEYSKFLYKTEVIERPGVLKDLKTMGSVSLFIFFI----TLLVL 884

  Fly   435 VKNAAATIQLYAL---NLSQKAKELKREKRKSDSLLFQMLPPSVAMQLK----QTQQVPAELYEA 492
            .:......:|..|   ...::.:|::..:..:..||..:||..||....    :.:.:..:.|:.
Zfish   885 ARQNEYYCRLDFLWKNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLARNWKNEDLYHQSYDL 949

  Fly   493 VTIYFSDIVGF----TEIAADCTPLEVVTFLNSIYRVFDERI---ECYDVYKVETIGDSYMVASG 550
            |.:.|:.|..|    ||...:...||.:..||.|...|||.:   :...|.|::|||.:||.|:|
Zfish   950 VCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATG 1014

  Fly   551 LPVKNGNKHISE-------IATMA---------LDLLDASSVFRIPRAGDEFVQIRCGVHTGPVV 599
            |....|.::..|       |.||.         ||:::..|.       ::| ::|.|::.|||.
Zfish  1015 LNATPGPEYTQEHDRQYMHIGTMVEFAFALVGKLDVINKHSF-------NDF-KLRVGINHGPVK 1071

  Fly   600 AGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGLM 664
            ||::|.:.|:|.::|:|||.||||:|||...||.:|||....||.: |:....||:|:|||||.:
Zfish  1072 AGVIGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEETSCILQTL-GYTCSCRGIINVKGKGEL 1135

  Fly   665 STYWL 669
            .||::
Zfish  1136 KTYFV 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:462453	58/340 (17%)
		CYCc	459..647	CDD:214485	68/214 (32%)
adcy2a	XP_692173.5	AcyC	104..529	CDD:441717	3/11 (27%)
		Guanylate_cyc	340..524	CDD:425528	3/6 (50%)
		Adcy_cons_dom	554..659	CDD:461877	23/115 (20%)
		Guanylate_cyc	942..1141	CDD:425528	73/208 (35%)