DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and adcy5

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001165056.1	Gene:	adcy5 / 562619	ZFINID:	ZDB-GENE-081104-470	Length:	1186	Species:	Danio rerio

Alignment Length:	402	Identity:	112/402 - (27%)
Similarity:	181/402 - (45%)	Gaps:	87/402 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 STLNYAPMLKNMYTNITS-------------------TKKFHRAKQMGT-----------TLLKN 364
            |:|||....:|...|.:|                   ...|.:...:|.           .|:..
Zfish   813 SSLNYTLWSQNRLCNSSSPTCNFPEYFSSCVLLSLLACSVFLQVSSIGKLFLMLFIEILYVLIME 877

  Fly   365 NPNVSNERSAIEYYELMNNYTDDLRILQKALRRLIKEYVDKTLVEADRKEAIGIAILVVVLIVSP 429
            .|.||          |.:|.  ||.::..||              |.......:...|.:.||:|
Zfish   878 VPEVS----------LFDNV--DLLVMANAL--------------APNNGTCIVDTRVPLKIVTP 916

  Fly   430 VIIVL-----------VKNAAATIQLYALNLSQKAKELKREKRKSDSLLFQMLPPSVAMQLKQTQ 483
            |:|.:           |::.|....|:.|..:::.:|::..:..:..||..:||..||......:
Zfish   917 VVITVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARE 981

  Fly   484 QVPAELY----EAVTIYFSDIVGFT----EIAADCTPLEVVTFLNSIYRVFDERI---ECYDVYK 537
            :...|||    |.|.:.|:.|..|:    |:.|:...:|.:..||.|...|||.|   :...:.|
Zfish   982 RRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDQFRQLEK 1046

  Fly   538 VETIGDSYMVASGLP----VKNGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPV 598
            ::|||.:||.||||.    .|.|..||..:|..|:.|:|...... ..:.:.| :::.|::.|||
Zfish  1047 IKTIGSTYMAASGLNDSTYDKAGRSHIRALADYAMRLMDQMKYIN-EHSFNNF-KMKIGLNMGPV 1109

  Fly   599 VAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGL 663
            |||::|.:.|:|.::|:|||.||||:|||..::|.:|.:::..|... .:..|:||::.|||||.
Zfish  1110 VAGVIGARKPQYDIWGNTVNVASRMDSTGVPERIQVTTDLYQVLSSY-NYTLEYRGVVKVKGKGE 1173

  Fly   664 MSTYWLTCKDGP 675
            |.||:|  ..||
Zfish  1174 MMTYFL--NGGP 1183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	18/95 (19%)
		HNOBA	<439..479	CDD:285003	10/39 (26%)
		CYCc	459..647	CDD:214485	67/202 (33%)
		Guanylate_cyc	485..669	CDD:278633	72/198 (36%)
adcy5	NP_001165056.1	AC_N	1..388	CDD:292831
		CYCc	354..548	CDD:214485
		Guanylate_cyc	390..574	CDD:278633
		DUF1053	598..687	CDD:283888
		CYCc	961..1155	CDD:214485	67/195 (34%)
		Guanylate_cyc	987..1181	CDD:278633	72/198 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810