DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and adcy6b

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_002666536.2	Gene:	adcy6b / 560807	ZFINID:	ZDB-GENE-090127-2	Length:	1174	Species:	Danio rerio

Alignment Length:	290	Identity:	98/290 - (33%)
Similarity:	159/290 - (54%)	Gaps:	21/290 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   402 YVDKTLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAAATIQLYALNLSQKAKELKREKRKSDSL 466
            |..:|:.:...:.:|.: ||.|.::...:....|::.|....|:.|..:::.:|::..:..:..|
Zfish   889 YCQETVTKVSLRVSIPV-ILTVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRL 952

  Fly   467 LFQMLPPSVAMQLKQTQQVPAELY----EAVTIYFSDIVGF----TEIAADCTPLEVVTFLNSIY 523
            |..:||..||......::...|||    |.|.:.|:.|..|    ||:.|:...:|.:..||.|.
Zfish   953 LHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYTELEANNEGVECLRLLNEII 1017

  Fly   524 RVFDERI--ECY-DVYKVETIGDSYMVASGLP----VKNGNKHISEIATMALDLLDASSVFRIPR 581
            ..|||.|  |.| .:.|::|||.:||.||||.    .|.|..||..:|..|:.|.:...... ..
Zfish  1018 ADFDEIISEEKYKQLEKIKTIGSTYMAASGLNDSTYDKEGRTHILALADYAMRLREQMKYIN-EH 1081

  Fly   582 AGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVG 646
            :.:.| |::.|::.||||||::|.:.|:|.::|:|||.||||:|||...:|.:|.:::..|:. .
Zfish  1082 SFNNF-QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDLYHVLES-K 1144

  Fly   647 GFRTEHRGLIDVKGKGLMSTYWLTCKDGPV 676
            |::.|.|||:.|||||.|:||:|  ..|||
Zfish  1145 GYQLECRGLVKVKGKGDMTTYFL--NSGPV 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564
		HNOBA	<439..479	CDD:285003	10/39 (26%)
		CYCc	459..647	CDD:214485	70/202 (35%)
		Guanylate_cyc	485..669	CDD:278633	77/198 (39%)
adcy6b	XP_002666536.2	AC_N	15..376	CDD:318454
		Guanylate_cyc	378..562	CDD:306677
		DUF1053	590..677	CDD:310728
		Guanylate_cyc	975..1169	CDD:306677	77/198 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810