DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and npr1a

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001038402.1	Gene:	npr1a / 560653	ZFINID:	ZDB-GENE-060503-539	Length:	1067	Species:	Danio rerio

Alignment Length:	749	Identity:	228/749 - (30%)
Similarity:	343/749 - (45%)	Gaps:	140/749 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LNGKAHKSGENPDPSPCPAGGSRM-------PTPSVKIDISTCQSNRPMESRTAPDDVNPSGEGG 59
            ||....:||..|   |......||       .|..|::|     .|...|...|..|:..:..|.
Zfish   369 LNDTMDRSGSRP---PGDVVNKRMWNRTYHGVTGLVQLD-----ENGDREIDFALWDMTDTKTGD 425

  Fly    60 LLLVPTHHNLQLDKIS--------VRSISSEDISNGGSGRCCNAAARNPAIKTGRRLQLMQMIIL 116
            ..:|..::..|...|.        ::.....||..      |.....|||. ..:.:.:.|||.:
Zfish   426 YQIVSVYNGSQKQMILEPGMKVHWLKGRPPPDIPE------CGFKNDNPAC-LAKTVTMHQMISI 483

  Fly   117 PFIPILALIVQTSVTLQEILEYRSAVADIETQVTIA------TDLGKVVTRLQLERSEVAFYIFT 175
            ....|..:||..:|.:...|:       :|.::|..      .|:....|...|.|:.....|..
Zfish   484 VVCFIFIIIVTVTVFIYRKLK-------LENELTAQLWRVHWEDIQMSNTEKVLRRACSKLTISL 541

  Fly   176 NGSKQRANLTLR-----FANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSRLNEFRD 235
            .||...:.||:.     :|.|.:...|:|....::    ....|..|:::......:...||...
Zfish   542 RGSNYGSLLTMDGNFQIYAKTGYYKGNITAIKYVN----KKRIELTRKVLFELKHMRDVQNEHLT 602

  Fly   236 R---VRLEPEESSI-TEVMNWYTSINRGLLHHLSEQIKETDNSGV---W--RYLVGFKNLLKSIE 291
            |   ..::|....| ||.      ..||.|..|.|      :.|:   |  ||     :|:..|
Zfish   603 RFIGACIDPPNICILTEY------CPRGSLQDLME------SEGITLDWMFRY-----SLINDI- 649

  Fly   292 CQNIATSFGIRYYGRGSLTAENFVSYVRYEFMAREMINSTLNYAPMLKNMYTNITSTKKFHRAKQ 356
            .:.:|..........|:|.:.|.|...|:       :....:|.....:..:|:.....|: |:|
Zfish   650 VKGMAFLHNSVIVSHGNLKSSNCVVDSRF-------VLKITDYGLESFHKDSNLDDVHAFY-ARQ 706

  Fly   357 MGTT--LLK--NNPNVSNERSAIEYYELMNNYTDDLRIL-------------QKALRRLIK---E 401
            :.|.  ||:  |.|....::..:..:.::   ..:|.:|             ::.:.|:::   .
Zfish   707 LWTAPELLRADNPPACGTQKGDVYSFGII---LQELALLKGVFYLEGPCLSPKEIIERVVEGRWP 768

  Fly   402 YVDKTLVEADRKEAIGIAIL---------------VVVLI-------VSPVIIVLVKNAAATIQL 444
            |:...|......|.:|..:|               :.||:       .|.::    .|..:.::.
Zfish   769 YLRPLLCPQSHSEEMGQLMLRCWSEDVNERPDFSQIKVLLRKNNCGYGSNIL----DNLLSRMEQ 829

  Fly   445 YALNLSQKAKE----LKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTE 505
            ||.||.:..:|    ...||||:::||:|:||.|||.|||:.:.|.||.:::||||||||||||.
Zfish   830 YANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTA 894

  Fly   506 IAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDL 570
            ::|:.||:||||.||.:|..||..|:.:||||||||||:|||.|||||:||..|..|||.|:|.|
Zfish   895 LSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLAL 959

  Fly   571 LDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHIT 635
            |:|...|||....:..:::|.|:|:|||.||:||.||||||||||||||||||||.|||.|||::
Zfish   960 LEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVS 1024

  Fly   636 EEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWL 669
            |.....||:...|:.|.||.:::||||.|.||||
Zfish  1025 EATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWL 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	50/267 (19%)
		HNOBA	<439..479	CDD:285003	17/43 (40%)
		CYCc	459..647	CDD:214485	114/187 (61%)
		Guanylate_cyc	485..669	CDD:278633	110/183 (60%)
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:107380	19/87 (22%)
		ANF_receptor	66..421	CDD:279440	15/59 (25%)
		PK_GC-A_B	540..814	CDD:270944	54/306 (18%)
		TyrKc	554..808	CDD:197581	49/286 (17%)
		HNOBA	<823..868	CDD:285003	17/44 (39%)
		CYCc	847..1032	CDD:214485	112/184 (61%)
		Guanylate_cyc	874..1060	CDD:278633	112/185 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810