DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and adcy2b

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_005170095.1	Gene:	adcy2b / 557902	ZFINID:	ZDB-GENE-060503-69	Length:	1142	Species:	Danio rerio

Alignment Length:	814	Identity:	171/814 - (21%)
Similarity:	306/814 - (37%)	Gaps:	238/814 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CPAGGSRMPTP-------SVKIDISTCQSNRPMESRTAPDDVNPSGEGGLLLVPTH--------- 66
            |.:|   :|.|       .||:.:..|::...:...|.. |:|       :.|..|
Zfish   390 CVSG---LPDPLLDHAKNCVKMGLDMCEAIEKVREATGV-DIN-------MRVGVHSGNVLCGVI 443

  Fly    67 -----------HNLQL----------DKISVRSISSEDISNG------GSGRCCNAAARNPAI-- 102
                       |::.|          .::.:.|::.|.: ||      |:|:..::..:...|
Zfish   444 GLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHL-NGAYKVEQGNGQSRDSYLKEHGIVT 507

  Fly   103 ------KTGRRLQLMQMIILPFIPILALIVQTSVTLQEILEYRSAV---ADIETQVTIATDLGKV 158
                  |..:|..|:...|.|  .:....::.||.:.:.||...|.   |::..:.::..:.|.:
Zfish   508 YLVINPKAEKRSPLLLSAIRP--TMYGAKMRASVRMTQYLESWGAAKPFANLHHRDSMTNENGMI 570

  Fly   159 VTR-LQL------ERSEVAFYIFTNGSKQR--ANLTLRFANTDHALNNMTTWSEISVPTAPDEDE 214
            .|| :.|      :|||     .|...|:|  ..|..|...|...:|:...|
Zfish   571 NTRDVPLGQYNCQQRSE-----RTKSQKKRFEEELNERIIRTIDGINSQKQW------------- 617

  Fly   215 DDREMMLNRYEFQSRLNEFRDRVRLEPEESSIT-EVMNWYTSINRGLLHHLSEQIKETDNSGVWR 278
                  |...:.| |::.|.....||.|..:.| ....:|.:.                 :.:..
Zfish   618 ------LKSEDIQ-RISLFFHNKALEKEYRATTLPAFKYYVTC-----------------ACLIF 658

  Fly   279 YLVGFKNLLKSIECQNIATSFGIRYYGRGSLTAENFVSYVRYEFMAREMINSTLNYAPMLKNMYT 343
            :.:....:|...:...:..|||:.:.....:....|..::   ....:..:.|:...|....:.|
Zfish   659 FCIFIVQVLVLPKTTVLEVSFGMAFLLLALILCICFAGHI---LQWGKAASCTMPRLPSSSKVIT 720

  Fly   344 NITSTKKFHR-AKQMGTTLL-------------------KNNPNVSNERSAIEYYELMN------ 382
            |    |.:.| |..|.||.|                   ..:.|:||......|.::.|
Zfish   721 N----KPWIRLALTMATTALILVMAVFNMFFLGEDRMVASTSLNISNSSMDGPYGQITNSSNNKF 781

  Fly   383 ----------------------NYTDDLRILQKAL-----------RRLIKEY---------VDK 405
                                  ||...:.|:..|:           ..::.:|         .|:
Zfish   782 YLPYFIYSCILGLISCSVFLRINYELKMIIMLGAVVAYNIIILQTHASILDDYSMALYKTQQPDR 846

  Fly   406 TLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAAATIQLYAL---NLSQKAKELKREKRKSDSLL 467
            ..|..|.|....|::.:..:    .::||.:......:|..|   ...::.:|::..:..:..||
Zfish   847 PGVLKDLKTMGSISLFIFFV----TLLVLARQNEYYCRLDFLWRNKFKKECEEIETMENLNRVLL 907

  Fly   468 FQMLPPSVAMQLK----QTQQVPAELYEAVTIYFSDIVGF----TEIAADCTPLEVVTFLNSIYR 524
            ..:||..||....    :.:.:..:.|:.|.:.|:.|..|    ||...:...||.:..||.|..
Zfish   908 ENVLPAHVAEHFLGRNWKNEDLYHQSYDTVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIA 972

  Fly   525 VFDERI---ECYDVYKVETIGDSYMVASGLPVKNG-------NKHISEIATMA---------LDL 570
            .|||.:   :...|.|::|||.:||.|:||.|..|       ::....|.||.         ||:
Zfish   973 DFDELLSKPKFSGVEKIKTIGSTYMAATGLNVTPGLEYAQYHDRQYMHIGTMVEFAFALVGKLDV 1037

  Fly   571 LDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHIT 635
            ::..|.       ::| ::|.|::.|||:||::|.:.|:|.::|:|||.||||||||...||.:|
Zfish  1038 INKHSF-------NDF-RMRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVT 1094

  Fly   636 EEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWL 669
            ||.:..||.: |:....||:|:|||||.:.|:::
Zfish  1095 EETNWILQTL-GYMCSCRGIINVKGKGDLRTFFV 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	48/305 (16%)
		HNOBA	<439..479	CDD:285003	9/42 (21%)
		CYCc	459..647	CDD:214485	69/214 (32%)
		Guanylate_cyc	485..669	CDD:278633	73/206 (35%)
adcy2b	XP_005170095.1	AC_N	<80..307	CDD:292831
		CYCc	283..486	CDD:214485	18/107 (17%)
		Guanylate_cyc	328..512	CDD:278633	21/133 (16%)
		DUF1053	542..646	CDD:283888	27/128 (21%)
		CYCc	899..1106	CDD:214485	69/215 (32%)
		Guanylate_cyc	929..1128	CDD:278633	73/208 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900