DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and ACXB

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster

Alignment Length:	746	Identity:	166/746 - (22%)
Similarity:	271/746 - (36%)	Gaps:	239/746 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 LALIVQTSVTLQEILEYRSAVADIETQVTIATDLGKVV--TRLQ-------------LERSEVAF 171
            ::|.:.....:||:..:|:...|:...|...|.|..|:  .:||             ||.:....
  Fly   376 VSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPG 440

  Fly   172 YIFTNG----SKQRANLTLRFANTDHALNN-------MTTWSEISVPT-----APDEDEDDREMM 220
            |:..:|    |...|..|: |..|:.|.::       |||:...:.|:     :.|......|:.
  Fly   441 YVHVSGRTLSSLNVAEYTV-FPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSYAEID 504

  Fly   221 LN-----------RYEFQSRLNEFRDRVRLEP-----------EESSITEVMNWYTSINRGLLHH 263
            :|           |....|  :|.|:..:..|           .::|..|      .:|.||...
  Fly   505 INALGASRKSPILRPTLMS--DELREEFKKMPVGGFNIRSPCCRDNSNDE------KVNHGLGMF 561

  Fly   264 LSEQIKETDNSGVWRYLVGFKNLLK-------SIEC-----QNIATSFGI--------------- 301
            .   :...|:|..|.||.....:||       .|.|     |.:...|.|
  Fly   562 C---VAFKDSSLEWSYLHKPDFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFL 623

  Fly   302 ----------------------RYYGRGSLTAENFVSYVRYEFMAREMINSTLNYAPMLKNMYTN 344
                                  |.|||.|.........:::.|:.|..|     |..::.:.|..
  Fly   624 TSLLFISWFKKVCWWRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVTI-----YMSIVASYYLL 683

  Fly   345 ITSTKKFHRAKQMGTTLL---KNNPNVSNERSAIEYYELMNN-------YTDDLRIL---QKALR 396
            |:            |.||   ||...:....|.:.:|:::.:       :||.:.::   .....
  Fly   684 IS------------TILLNCDKNQYELDVINSKLYHYDIVTDNCFNPWVFTDMISLIVGVSYTFA 736

  Fly   397 RLIKEYVDKTLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAAAT-----------IQLYALNLS 450
            |:  .:..|.|:..    ...:|.||:|......|.   :::|.|           :::..:.|:
  Fly   737 RI--PFALKMLITC----CATVAYLVIVFFQYSFIF---EHSATTTPFMKAELAHCLRVCMMLLT 792

  Fly   451 QKAKELKRE---------------KRKSDS--------LLFQMLPPSVA---MQLKQTQQVPAEL 489
            ..|||.:.|               |:|:..        ||..:||..|.   :......::..|.
  Fly   793 MYAKERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYLDSVANHELYYEN 857

  Fly   490 YEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVY----KVETIGDSYMVASG 550
            |:.|::.|:.::.|   ..|...|.|   ||.|...||..:..|..|    |::.:|.:||.|.|
  Fly   858 YKMVSVMFAMLINF---QMDLPSLRV---LNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACG 916

  Fly   551 LPV-----KNGNK-HIS----------------------EIA----TMALDLLDASSVFRIPRAG 583
            |..     |.|:: |.|                      |:|    |.||||:...||.....||
  Fly   917 LDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAG 981

  Fly   584 DEF------VQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSL 642
            ..|      .:|..|:.||.::||:||...|.|.::|:.||.||||||||....||:|:|..:.|
  Fly   982 RPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANIL 1046

  Fly   643 QQVGGFRTEHRGLIDVKGKGLMSTYWLTCKD 673
            :|. .....:||:..|||:|.:.||::...|
  Fly  1047 EQF-DIMCMYRGMTFVKGRGEIPTYFVGIDD 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	61/351 (17%)
		HNOBA	<439..479	CDD:285003	14/76 (18%)
		CYCc	459..647	CDD:214485	73/255 (29%)
		Guanylate_cyc	485..669	CDD:278633	73/225 (32%)
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831
		CYCc	249..459	CDD:214485	17/82 (21%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	24/108 (22%)
		CYCc	825..1047	CDD:214485	68/227 (30%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	73/225 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810