DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	720	Identity:	120/720 - (16%)
Similarity:	227/720 - (31%)	Gaps:	259/720 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PCPAGGSRMPTPSVKIDISTCQSNRPMESRTAPDDVNPSGEGGLLLVPTHHNLQLDKISVRSISS 81
            |.|||....|.|                    |:...|...||:                 .:..
  Rat     6 PVPAGSLEPPEP--------------------PEAAAPRRPGGI-----------------RVLK 33

  Fly    82 EDISNGGSGRCCNAAARNPAIKTGRRLQLMQMIILPFIPILALIVQTSVTLQEILEYRSAVADIE 146
            .::.:.||..|.|..:|   ..:..|..|.:.:....:.:......|:.|.      .::.:...
  Rat    34 RNMKHNGSRNCLNRRSR---FGSRERDWLREDVKRGCVYLYGADTTTATTT------TTSSSSSS 89

  Fly   147 TQVTIATDLGKVVTRLQLERSEV-------AFYIFTNGSKQRANLTLRFANTDHALNNMTTWSEI 204
            :..:.::||..|:..::...||:       :.|:..:|     :|..|...|:..|..:
  Rat    90 SSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQLHG-----DLVRRLEPTERPLQIV------ 143

  Fly   205 SVPTAPDEDEDDREMMLNRYEFQSRLNEFRDRVRLEPEE-------------------------- 243
                               |::.|||. |.|.||::.|.
  Rat   144 -------------------YDYLSRLG-FEDPVRIQEEATNPDLSCMIRFYGEKPCQMDHLDRIL 188

  Fly   244 -SSITEVMNWYTSINR-----------------------GLLHHLS------EQIKETDNSGVW- 277
             |.|..|....|.:::                       |.:|.|.      |::|...:|..:
  Rat   189 LSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQHSLAFS 253

  Fly   278 -------RYLVGFKNLLK---------SIECQNIATSFGIRYYGRGSLTAENFVSY------VRY 320
                   .|.|.|:.|.:         .:..|.|:| ..:..|....:....|.|.      :|:
  Rat   254 SAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRIST-VDLSCYSLEEVPEHLFYSQDITYLNLRH 317

  Fly   321 EFMARE------------------MINSTLNYAPMLKNMYTNIT----STKKFH-RAKQMG---- 358
            .||..|                  :.::.|...|:|....:.:|    |...|| ...|:|
  Rat   318 NFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPVLLCEISTLTELNLSCNGFHDLPSQIGNLLN 382

  Fly   359 --TTLLKNN------PNVSNERSAIEYYELMNNYTDDLRILQKALRRLIKEYVDKTLVEADRKEA 415
              |..|..|      ..:.|.:.........||::....:|:|.      ..:||.::..:|.|.
  Rat   383 LQTLCLDGNVLTALPDELGNLQQLTSLGISFNNFSQIPEVLEKL------TMLDKVVMAGNRLEI 441

  Fly   416 IGIAILV-------VVLIVSPVIIVLVKNAAATIQLYALNLSQKAKELKREKRKSDSLLFQMLPP 473
            :.:.:|.       |.|.::.:..|:::|......:..::|        |:.:.:|      |..
  Rat   442 LNLGVLTRMNHVKHVDLRMNHLKTVIIENLEGNKHITHMDL--------RDNQLTD------LDL 492

  Fly   474 SVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVV------TFLNSIYRVFDERIEC 532
            |....|:|......:|.|.....||    ...:.|:...|..|      :.|.|: .:....:||
  Rat   493 SSLCSLEQLHCERNQLRELTLSGFS----LRNLYANWNKLTAVNVYPVPSLLTSL-ELSRNLLEC 552

  Fly   533 Y-----DVYKVETIGDSYMVASGLPVK-----------NGNKHISEIATMA----LDLLDA--SS 575
            .     :..|:|.:..||.:.:.:|::           .|:.||..:..:.    |::||.  ::
  Rat   553 IPDWACEAKKLEILDISYNLLTEVPMRILSSLSLRKLMVGHNHIHVLPALVEHIPLEVLDVQHNT 617

  Fly   576 VFRIP 580
            :.|:|
  Rat   618 LSRLP 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	58/357 (16%)
		HNOBA	<439..479	CDD:285003	5/39 (13%)
		CYCc	459..647	CDD:214485	29/150 (19%)
		Guanylate_cyc	485..669	CDD:278633	24/124 (19%)
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761	22/148 (15%)
		PH_PHLPP-like	185..279	CDD:270131	14/93 (15%)
		PLN00113	284..>762	CDD:215061	67/365 (18%)
		leucine-rich repeat	289..309	CDD:275380	4/20 (20%)
		leucine-rich repeat	310..336	CDD:275380	4/25 (16%)
		leucine-rich repeat	337..359	CDD:275380	3/21 (14%)
		leucine-rich repeat	360..382	CDD:275380	6/21 (29%)
		leucine-rich repeat	383..405	CDD:275380	4/21 (19%)
		leucine-rich repeat	406..428	CDD:275380	4/27 (15%)
		leucine-rich repeat	429..452	CDD:275380	5/22 (23%)
		leucine-rich repeat	453..476	CDD:275380	4/22 (18%)
		leucine-rich repeat	477..497	CDD:275380	5/33 (15%)
		leucine-rich repeat	498..517	CDD:275380	4/18 (22%)
		leucine-rich repeat	518..539	CDD:275380	3/20 (15%)
		leucine-rich repeat	540..562	CDD:275380	4/22 (18%)
		leucine-rich repeat	563..584	CDD:275380	4/20 (20%)
		leucine-rich repeat	586..607	CDD:275380	3/20 (15%)
		leucine-rich repeat	608..631	CDD:275380	5/15 (33%)
		leucine-rich repeat	632..681	CDD:275380
		leucine-rich repeat	682..705	CDD:275380
		leucine-rich repeat	706..728	CDD:275380
		leucine-rich repeat	751..772	CDD:275380
		PP2Cc	820..1069	CDD:238083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900