Protein Alignment CG33958 and Gucy1a1

DIOPT Version :10

• Sequence 1: NP_001033958.1
• Gene: CG33958 / 37088
• FlyBaseID: FBgn0053958
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_058786.2
• Gene: Gucy1a1 / 497757
• RGDID: 68436
• Length: 690
• Species: Rattus norvegicus
• Alignment Length: 636
• Identity: 173/636 - (27%)
• Similarity: 264/636 - (41%)
• Gaps: 138/636 - (21%)

  Fly    94 NAAARNPAIKTGR-RLQLMQM------IILPFIPILALIVQTSVTLQEILEYRSAVADIETQVTI 151
            ||...:|..||.| |:.|..:      :|.|....|.|.:|.::...:|.|.|::....:.:..|
  Rat    53 NAEGSHPQRKTSRNRVYLHTLAESIGKLIFPEFERLNLALQRTLAKHKIKENRNSSEKEDLERII 117

  Fly   152 ATD---LGKVVTRLQLERSEVAFYIFTNGSKQRANL---TLR-FANTDHALNNMTTWSEISVPTA 209
            |.:   .|..|..|:....|..|.|.....:....:   ||: |.|:...|...::..:.:....
  Rat   118 AEEAIAAGVPVEALKDSLGEELFKICYEEDEHILGVVGGTLKDFLNSFSTLLKQSSHCQEAERRG 182

  Fly   210 PDED------EDDREMMLNRYEFQSR----------------LNEFRDRVRLEPE--ESSITEVM 250
            ..||      :.|::.:...|.|..|                |.|....|.|.|.  .|..||.:
  Rat   183 RLEDASILCLDKDQDFLNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLMPPCFRSECTEFV 247

  Fly   251 NWYTSINRGLLHHLSEQIKETDNSGVWRYLVGFKN-----LLKSIECQNIATSF----------- 299
            |     ...||:  |..:|.|..|     |...|.     :..|:.|:.....|
  Rat   248 N-----QPYLLY--SVHVKSTKPS-----LSPGKPQSSLVIPTSLFCKTFPFHFMLDRDLAILQL 300

  Fly   300 --GIR-------YYGRGSLTAENFVSYVRYEFMAREMINSTLNYAPMLKNM--------YTNITS 347
              |||       :.|:     .||..:  :|.:..: ||.|.:....:.||        :.|:
  Rat   301 GNGIRRLVNKRDFQGK-----PNFEEF--FEILTPK-INQTFSGIMTMLNMQFVIRVRRWDNL-- 355

  Fly   348 TKKFHRAKQM----------GTTLLKNNPNVSNERSAIEYYELMNNYTDDLRILQKALRRLIKEY 402
            .||..|...:          ...|...:|.|..    :|.:.....|..|:.| ..|||
  Rat   356 VKKSSRVMDLKGQMIYIVESSAILFLGSPCVDR----LEDFTGRGLYLSDIPI-HNALR------ 409

  Fly   403 VDKTLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAAATIQLYALNLSQKAKELKREKRKSDSLL 467
             |..|:....:...|:                 |.....::   ..|....:.|:.||:|:..||
  Rat   410 -DVVLIGEQARAQDGL-----------------KKRLGKLK---ATLEHAHQALEEEKKKTVDLL 453

  Fly   468 FQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIEC 532
            ..:.|..||.||.|.|.|.|:.:..||:.||||||||.|.:.|:||:|:|.||::|..||::...
  Rat   454 CSIFPSEVAQQLWQGQIVQAKKFNEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGE 518

  Fly   533 YDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGP 597
            .||||||||||:|.||.||. :..:.|..:||.|||.:::.|:....|..  |.:::|.|:|:|.
  Rat   519 LDVYKVETIGDAYCVAGGLH-RESDTHAVQIALMALKMMELSNEVMSPHG--EPIKMRIGLHSGS 580

  Fly   598 VVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGF 648
            |.||:||.|||||||||:.|..|::.||....:||:::...:..|:...||
  Rat   581 VFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGF 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:462453	60/307 (20%)
		CYCc	459..647	CDD:214485	84/187 (45%)
Gucy1a1	NP_058786.2	HNOBA	276..465	CDD:462234	43/230 (19%)
		Guanylate_cyc	471..642	CDD:425528	74/164 (45%)