Protein Alignment CG33958 and NPR2

DIOPT Version :10

• Sequence 1: NP_001033958.1
• Gene: CG33958 / 37088
• FlyBaseID: FBgn0053958
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_001365852.1
• Gene: NPR2 / 4882
• HGNCID: 7944
• Length: 1050
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 208/629 - (33%)
• Similarity: 298/629 - (47%)
• Gaps: 179/629 - (28%)

  Fly   148 QVTIATDLGKVVTRLQLERSEVAF---YIFTNGSKQRANLTLR----------------FANTDH 193
            ::.:..:|..::.|::.|  |:.|   ..:..|:..|..|:||                ||||.|
Human   483 KLMLEKELASMLWRIRWE--ELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGH 545

  Fly   194 ALNNMTTWSEISVPTAPDEDEDDREMMLN-------RYEFQSR-------------LNEFRDRVR 238
            ...|:.....::    ....|..|:::..       ::...:|             :.|:..|..
Human   546 FKGNVVAIKHVN----KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGS 606

  Fly   239 LEP--EESSITEVMNW---YTSIN---RGL--LHHLSEQIKETDNSGVWRYLVGFKNLLKSIECQ 293
            |:.  |..||.  ::|   |:.||   :|:  ||          ||     ::.....|||..|.
Human   607 LQDILENDSIN--LDWMFRYSLINDLVKGMAFLH----------NS-----IISSHGSLKSSNCV 654

  Fly   294 NIATSFGIRY--YGRGSL--TAENFVSYVRYEFMAREMINSTLNYAPMLKNMYTNITSTKKFHRA 354
             :.:.|.::.  ||..|.  |||...|:..|                                 |
Human   655 -VDSRFVLKITDYGLASFRSTAEPDDSHALY---------------------------------A 685

  Fly   355 KQMGTT--LLKNNPNVSNERSAIEYYE---------LMNN--YTDDL-----RILQK---ALRRL 398
            |::.|.  ||..||..:......:.|.         |.:.  |.:.|     .|:||   ..|..
Human   686 KKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPY 750

  Fly   399 IKEYVDKT--------LVE-------ADR--------------KEAIGIAILVVVLIVSPVIIVL 434
            .:..:|:|        |:|       |:|              ||. |.:||
Human   751 FRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEG-GTSIL------------- 801

  Fly   435 VKNAAATIQLYALNLSQKAKELKR----EKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTI 495
             .|....::.||.||.:..:|..:    ||||:::||:|:||.|||.|||:.:.|.||.:::|||
Human   802 -DNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTI 865

  Fly   496 YFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHI 560
            |||||||||.::|:.||::|||.||.:|..||..|:.:||||||||||:|||.||||.:||.:|.
Human   866 YFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHA 930

  Fly   561 SEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMES 625
            .|||.|||.||||.|.|||.....:.:::|.|||||||.||:||.||||||||||||||||||||
Human   931 PEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMES 995

  Fly   626 TGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWL 669
            .|:|.|||::....|:|.::|.|:.|.||.:::||||.|.||||
Human   996 NGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWL 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:462453	60/310 (19%)
		CYCc	459..647	CDD:214485	115/187 (61%)
NPR2	NP_001365852.1	PBP1_NPR_B	26..421	CDD:380607
		PK_GC-A_B	521..795	CDD:270944	60/328 (18%)
		HNOBA	<801..849	CDD:462234	19/61 (31%)
		CYCc	828..1012	CDD:214485	114/183 (62%)