DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and NPR2

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_024303324.1	Gene:	NPR2 / 4882	HGNCID:	7944	Length:	1103	Species:	Homo sapiens

Alignment Length:	653	Identity:	213/653 - (32%)
Similarity:	305/653 - (46%)	Gaps:	174/653 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 QVTIATDLGKVVTRLQLERSEVAF---YIFTNGSKQRANLTLR----------------FANTDH 193
            ::.:..:|..::.|::.|  |:.|   ..:..|:..|..|:||                ||||.|
Human   483 KLMLEKELASMLWRIRWE--ELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGH 545

  Fly   194 ALNNMTTWSEISVPTAPDEDEDDREMMLN-------RYEFQSR-------------LNEFRDRVR 238
            ...|:.....::    ....|..|:::..       ::...:|             :.|:..|..
Human   546 FKGNVVAIKHVN----KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGS 606

  Fly   239 LEP--EESSITEVMNW---YTSIN---RGL--LHHLSEQIKETDNSGVWRYLVGFKNLLKSIECQ 293
            |:.  |..||.  ::|   |:.||   :|:  ||          ||     ::.....|||..|.
Human   607 LQDILENDSIN--LDWMFRYSLINDLVKGMAFLH----------NS-----IISSHGSLKSSNCV 654

  Fly   294 NIATSFGIRY--YGRGSL--TAENFVSYVRYE--------------FMARE------------MI 328
             :.:.|.::.  ||..|.  |||...|:..|.              |..|:            |.
Human   655 -VDSRFVLKITDYGLASFRSTAEPDDSHALYASEAHPHNPLFILLLFPPRDGGRGRWSDSNIGMS 718

  Fly   329 NSTLNYAPMLKNMYTNITSTKKFHRAKQMGTTLLKNNPNVSNERSAIEYYE---------LMNN- 383
            ...|..||...........::|...|.:    ||..||..:......:.|.         |.:.
Human   719 PGGLGGAPFRGTWPAGFLFSEKLWTAPE----LLSGNPLPTTGMQKADVYSFGIILQEIALRSGP 779

  Fly   384 -YTDDL-----RILQK---ALRRLIKEYVDKT--------LVE-------ADR------------ 412
             |.:.|     .|:||   ..|...:..:|:|        |:|       |:|
Human   780 FYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRR 844

  Fly   413 --KEAIGIAILVVVLIVSPVIIVLVKNAAATIQLYALNLSQKAKELKR----EKRKSDSLLFQML 471
              ||. |.:||              .|....::.||.||.:..:|..:    ||||:::||:|:|
Human   845 FNKEG-GTSIL--------------DNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQIL 894

  Fly   472 PPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVY 536
            |.|||.|||:.:.|.||.:::||||||||||||.::|:.||::|||.||.:|..||..|:.:|||
Human   895 PHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVY 959

  Fly   537 KVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAG 601
            |||||||:|||.||||.:||.:|..|||.|||.||||.|.|||.....:.:::|.|||||||.||
Human   960 KVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAG 1024

  Fly   602 IVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMST 666
            :||.||||||||||||||||||||.|:|.|||::....|:|.::|.|:.|.||.:::||||.|.|
Human  1025 VVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRT 1089

  Fly   667 YWL 669
            |||
Human  1090 YWL 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	65/334 (19%)
		HNOBA	<439..479	CDD:285003	17/43 (40%)
		CYCc	459..647	CDD:214485	115/187 (61%)
		Guanylate_cyc	485..669	CDD:278633	112/183 (61%)
NPR2	XP_024303324.1	Periplasmic_Binding_Protein_Type_1	26..421	CDD:324556
		PK_GC-A_B	521..848	CDD:270944	65/352 (18%)
		HNOBA	<857..902	CDD:311573	17/44 (39%)
		CYCc	881..1065	CDD:214485	114/183 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810