Protein Alignment CG33958 and NPR1

DIOPT Version :9

• Sequence 1: NP_001033958.1
• Gene: CG33958 / 37088
• FlyBaseID: FBgn0053958
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_000897.3
• Gene: NPR1 / 4881
• HGNCID: 7943
• Length: 1061
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 185/558 - (33%)
• Similarity: 276/558 - (49%)
• Gaps: 134/558 - (24%)

  Fly   131 TLQEILEYRSAVADIETQVTIATDLGKVVTRLQLERSEVAFYIFTNGSKQRANLTL--RFA--NT 191
            :||:|||..|...|...:.::..|:.|.:  |.|....:.    ::|:.:.:|..:  ||.  .|
Human   619 SLQDILENESITLDWMFRYSLTNDIVKGM--LFLHNGAIC----SHGNLKSSNCVVDGRFVLKIT 677

  Fly   192 DHALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSRLNEFRDRVRLEPEESSITEVMNWYTSI 256
            |:.|.:                                   |||   |:||:.........:|:.
Human   678 DYGLES-----------------------------------FRD---LDPEQGHTVYAKKLWTAP 704

  Fly   257 NRGLLHHLSEQIKETDNSGVWRYLVGFKNLLKSIECQNIATSFGIRYYGRGSLTAENFVSYVRYE 321
            .  ||...|..::.:....|:.:         .|..|.||...|: ::..|
Human   705 E--LLRMASPPVRGSQAGDVYSF---------GIILQEIALRSGV-FHVEG-------------- 743

  Fly   322 FMAREMINSTLNYAPMLKNMYTNITSTKKFHRAKQMGTTLLKNNPNVSNERSAIEYYELMNNYTD 386
                      |:.:|  |.:...:|      |.:|.     ...|:::           :.::.:
Human   744 ----------LDLSP--KEIIERVT------RGEQP-----PFRPSLA-----------LQSHLE 774

  Fly   387 DLRILQKAL------RRLIKEYVDKTLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAAATIQLY 445
            :|.:|.:..      .|...:.:..||.:.:|:.:..|                :.|..:.::.|
Human   775 ELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNI----------------LDNLLSRMEQY 823

  Fly   446 ALNLSQKAKELKR----EKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEI 506
            |.||.:..:|..:    ||||:::||:|:||.|||.|||:.:.|.||.:::||||||||||||.:
Human   824 ANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAL 888

  Fly   507 AADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLL 571
            :|:.||::|||.||.:|..||..|:.:||||||||||:|||.|||||:||..|..|:|.|||.||
Human   889 SAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALL 953

  Fly   572 DASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITE 636
            ||...|||.....|.:::|.|:|||||.||:||.||||||||||||||||||||.|||.|||::.
Human   954 DAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSS 1018

  Fly   637 EMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWLTCKDG 674
            |....|::.|||..|.||.:::||||.:.||||..:.|
Human  1019 ETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERG 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	35/246 (14%)
		HNOBA	<439..479	CDD:285003	17/43 (40%)
		CYCc	459..647	CDD:214485	115/187 (61%)
		Guanylate_cyc	485..669	CDD:278633	112/183 (61%)
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:107380
		ANF_receptor	54..414	CDD:279440
		PK_GC-A_B	534..807	CDD:270944	47/291 (16%)
		TyrKc	547..801	CDD:197581	45/285 (16%)
		HNOBA	<816..861	CDD:285003	17/44 (39%)
		CYCc	840..1032	CDD:214485	118/191 (62%)
		Guanylate_cyc	867..1053	CDD:278633	114/185 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810