DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and Adcy1

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_033752.1	Gene:	Adcy1 / 432530	MGIID:	99677	Length:	1118	Species:	Mus musculus

Alignment Length:	270	Identity:	83/270 - (30%)
Similarity:	145/270 - (53%)	Gaps:	24/270 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 LVVVLIVSPVIIVLVKNAAATIQ---LYALNLSQKAKELKREKRKSDSLLFQMLPPSVA----MQ 478
            ::.:|:.|..:.:..:.....::   |:|....::..:::|.|..:..:||.:||..||    |.
Mouse   787 IMAILLFSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMS 851

  Fly   479 LKQTQQVPAELYEAVTIYFSDIVGFT----EIAADCTPLEVVTFLNSIYRVFDERIE---CYDVY 536
            ..:...:..:.|..|.:.|:.|..|.    |:..:...:|.:..||.|...|||.::   ..|:.
Mouse   852 NPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLE 916

  Fly   537 KVETIGDSYMVASGLPVKNGNK-------HISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVH 594
            |::|||.:||.|.||....|.:       |:..:|..|:|:.|....... ::.::|| :|.|::
Mouse   917 KIKTIGSTYMAAVGLAPTAGTRAKKSISSHLCTLADFAIDMFDVLDEINY-QSYNDFV-LRVGIN 979

  Fly   595 TGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVK 659
            .||||||::|.:.|:|.::|:|||.||||:|||...:|.:|||:|..|::. .::...||.:.||
Mouse   980 VGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLKRC-SYQFVCRGKVSVK 1043

  Fly   660 GKGLMSTYWL 669
            |||.|.||:|
Mouse  1044 GKGEMLTYFL 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564
		HNOBA	<439..479	CDD:285003	11/46 (24%)
		CYCc	459..647	CDD:214485	67/205 (33%)
		Guanylate_cyc	485..669	CDD:278633	69/197 (35%)
Adcy1	NP_033752.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		AC_N	<158..291	CDD:292831
		CYCc	257..452	CDD:214485
		Guanylate_cyc	293..475	CDD:278633
		Interaction with calmodulin. /evidence=ECO:0000250	492..519
		CYCc	825..1036	CDD:214485	68/213 (32%)
		Guanylate_cyc	858..1055	CDD:278633	70/199 (35%)
		Interaction with calmodulin. /evidence=ECO:0000250	1023..1046		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1079..1118
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810