DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and CG43373

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster

Alignment Length:	687	Identity:	144/687 - (20%)
Similarity:	271/687 - (39%)	Gaps:	181/687 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ESRTAPDDVNPSGEGGLLLVPTHHNLQLDKISVRSISSEDISNGGSGRC-----C---NAAARNP 100
            ||...|:|                  ::::..:|:|.:..|.:..:..|     |   |...|..
  Fly   952 ESAKDPED------------------EVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKY 998

  Fly   101 AIKTGRRLQLMQMIILPFIPILALIVQTSVTLQEILEYRSAVADIETQVTIATDLGKVVTRLQLE 165
            |.:..|      |:.:.|...|.:::.||:  ..::.::|::..:.........||.:|..:...
  Fly   999 ASEPDR------MLCVYFYCSLLVLLGTSI--MRLVVFQSSLLTLALSTGALLLLGFLVFLVACH 1055

  Fly   166 R------SEVAFYIFTNGSKQRANLTLRFANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRY 224
            :      |::..:.....|.:|.:....||:.  ||..:||                   :|..:
  Fly  1056 KINFQLPSDIKRFSLRIHSNRRISQLFAFASV--ALIVLTT-------------------LLAMF 1099

  Fly   225 EFQSRLNEFRDRVRLEPEESSITEVMNWYTSINRGLLHHLSEQIKETDNSGVWRYLVGFKNLLKS 289
            :...|..|...|.|             ::..:|..:      .:.:|:.:            .|.
  Fly  1100 QESGRQMELLQRRR-------------FWLDVNGSI------SLNDTELN------------TKM 1133

  Fly   290 IECQNIATSFGIRYYGRGSLTAENFVSYVRYEFMAREMINSTL------NYAPMLKNMYTNITST 348
            .:.:.....|.:.|.....||..:.:|...|:.: |.::...|      :|.....|:|:
  Fly  1134 YDAEEPDCDFYLAYNTFLLLTLLSMMSCATYQVL-RILLKLLLLLLASGSYMACSSNLYS----- 1192

  Fly   349 KKFHRAKQMGTTLLKNNPNVSNERSAIEYYELMNNYTDDLRILQKALRRLIKEYVDKTLVEADRK 413
                |:::|...|       :||.:.:.|                        .:|...:
  Fly  1193 ----RSREMSQEL-------ANEEALLRY------------------------IIDSIFL----- 1217

  Fly   414 EAIGIAILVVVLIVSPVIIVLVKNAAATIQL---YALNLSQKAKELKREKRKSDSLLFQMLPPSV 475
                .|.::.::..|       ....||.:|   :.|..:::.::::..:..:..||..:||..|
  Fly  1218 ----FAFMLALIFHS-------HQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHV 1271

  Fly   476 AMQLKQTQQVPAELY----EAVTIYFSDIVGFT----EIAADCTPLEVVTFLNSIYRVFD----- 527
            |......::...:||    ::|.|.|:.|..|:    |:..:...:|.:..||.|...||
  Fly  1272 AEHFLSREKHLDDLYHEQCDSVCILFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSE 1336

  Fly   528 ERIECYDVYKVETIGDSYMVASGLPVKNGNK----HISEIATMALDLLDASSVFRIPRAGDEFVQ 588
            ||..|  :.|:::.|.:||.||||.....::    |::.:|..||.|.|  .:..:........:
  Fly  1337 ERFRC--IEKIKSTGATYMAASGLTANTCDRVNFSHVTAMADYALQLFD--KIEEVNMHSFNNFR 1397

  Fly   589 IRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHR 653
            :|.|::.||||||::|...|:|.::|:.||.||||:|||....|.:|:||...|:. .||....|
  Fly  1398 MRIGINIGPVVAGVIGACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEG-RGFELTCR 1461

  Fly   654 GLIDVKGKGLMSTYWLTCKDGPVRAREEISWRADIQP 690
            |.:||||||.|.||:|..: .|:.|:|....:.:::|
  Fly  1462 GSVDVKGKGSMITYFLKGR-RPIDAKELELAKTEVEP 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	35/248 (14%)
		HNOBA	<439..479	CDD:285003	10/42 (24%)
		CYCc	459..647	CDD:214485	63/204 (31%)
		Guanylate_cyc	485..669	CDD:278633	70/200 (35%)
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485
		Guanylate_cyc	722..895	CDD:278633
		DUF1053	<949..1005	CDD:283888	13/76 (17%)
		CYCc	1259..1455	CDD:214485	63/200 (32%)
		Guanylate_cyc	1285..1479	CDD:278633	71/198 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810