DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and CG10738

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster

Alignment Length:	766	Identity:	220/766 - (28%)
Similarity:	319/766 - (41%)	Gaps:	237/766 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GLLLVPT--HHNLQLDKIS-------VRSISSEDISNG-----------GSGRCCNAAARNPAIK 103
            ||..|.|  |.|..|..||       ::..|..|...|           |..:|.|......|..
  Fly   434 GLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAI 498

  Fly   104 TGRRLQLMQMIILPFIPILALIVQTSVTLQEILEYRSAVADIETQVTIATDLGKVVTRLQLERSE 168
            .|..|.|:.::              |:.|.....|..             :|..::.::.....:
  Fly   499 AGGALLLLSLV--------------SLVLYRNWRYEQ-------------ELDSLLWKIDFREVQ 536

  Fly   169 VAFYIFTNGSKQRANLTLRFANTDHALNN------------MTTWSEISVPTAPDEDEDDREMML 221
                |..|..:|::.     ..|.|.||:            :...|::|:.:.||.|
  Fly   537 ----IHENEREQQSQ-----KQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDAD-------- 584

  Fly   222 NRYEFQSRLNEFRDRVRLEPEESSITEVMNWYTSI------NRGLLHHLSEQIKETDNSGVWRYL 280
                       ||                  ||:|      .:|.|:.:.:..|::.:  :.|.:
  Fly   585 -----------FR------------------YTTIFTPIGLYKGQLYAIKKVRKKSVD--ITREM 618

  Fly   281 VGFKNLLKSIECQNIATSFGI-----------RYYGRGSL--TAEN--------FVSYVRYEFMA 324
            .....||:.....||....|.           .|..||||  ..||        |::     .|.
  Fly   619 KKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIA-----SMV 678

  Fly   325 REMINST--LNYAPM--------------------------------LKNMYTNI-----TSTKK 350
            .::|...  |:.:|:                                :::..|::     ...|.
  Fly   679 ADIIRGVIYLHDSPIRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKL 743

  Fly   351 FHRAKQMGTTLLKNNPN---VSNERS-----AIEYYEL--------------------------- 380
            .:||.:    ||:..|:   :..:|.     .|..||:
  Fly   744 LYRAPE----LLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDY 804

  Fly   381 MNNYTDDLRILQKALRRLIKEYVDKTLVE--ADRKE------AIGIAILVVVLIVSPVIIVLVKN 437
            :|.|...|:.|:.|.     :.|.:.|.|  |:|.|      .|...:..:...:.|.|.   .|
  Fly   805 LNPYRPSLQPLETAF-----DCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIF---DN 861

  Fly   438 AAATIQLYALNL----SQKAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFS 498
            ..|.::.||.||    ..:..:|:.||:|:|:||.:|||..||.|||:..:|..|.||.|:||||
  Fly   862 MMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFS 926

  Fly   499 DIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEI 563
            ||||||.::|:||||:||.|||.:|..||..|..|||||||||||:|||.||||::||:.|.:||
  Fly   927 DIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEI 991

  Fly   564 ATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGE 628
            |||:|.||.|.|.|:|.......:.:|.|:|:|||.||:||.||||||||||||||||||||:|.
  Fly   992 ATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGV 1056

  Fly   629 AQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWLTCKDGPVRAR 679
            ..|||.:.:....|.::||:....||:|.:||||...||||..:|...|.|
  Fly  1057 PLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEEARTR 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	54/349 (15%)
		HNOBA	<439..479	CDD:285003	17/43 (40%)
		CYCc	459..647	CDD:214485	111/187 (59%)
		Guanylate_cyc	485..669	CDD:278633	108/183 (59%)
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	3/6 (50%)
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	54/335 (16%)
		TyrKc	597..847	CDD:197581	44/265 (17%)
		HNOBA	<862..907	CDD:285003	17/44 (39%)
		CYCc	886..1078	CDD:214485	113/191 (59%)
		Guanylate_cyc	913..1099	CDD:278633	110/185 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910