Protein Alignment CG33958 and GUCY1B1

DIOPT Version :10

• Sequence 1: NP_001033958.1
• Gene: CG33958 / 37088
• FlyBaseID: FBgn0053958
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: XP_011530203.1
• Gene: GUCY1B1 / 2983
• HGNCID: 4687
• Length: 662
• Species: Homo sapiens
• Alignment Length: 637
• Identity: 165/637 - (25%)
• Similarity: 261/637 - (40%)
• Gaps: 167/637 - (26%)

  Fly    89 SGRCCNAAARNPAIKTGRRLQL--------MQMIILPFIPILALIVQTSVTLQEILEYRSAVADI 145
            |.||.:|       :.|:.|.|        :|.|::..|..:|..:..:....::::.|:...|
Human   119 SFRCTDA-------EKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECD- 175

  Fly   146 ETQVTIATDLGKVVTRLQLERSEVAFYIFTNGSKQRANLTLRFANTDHALNNMTTWSEISVPT-- 208
            .||..|.          :.|..|..||                .:.|....|.|..|.||..|
Human   176 HTQFLIE----------EKESKEEDFY----------------EDLDRFEENGTQESRISPYTFC 214

  Fly   209 --APDEDEDDREMMLNRYEFQSRLNEFRDRVRLEPEESSITEVMNW---YTSIN-RGLLHHLSEQ 267
              .|.....||::::.    |.....:|...:|:|...|:..|.:.   :..|: .|:|.|::..
Human   215 KAFPFHIIFDRDLVVT----QCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTV 275

  Fly   268 IKETDNSGVWRYLVGFKNLLKSIECQNIATSFGIRYYGRGSLTAENFVSYVRYEFMAREMINSTL 332
            .       |.|...|..::.| :||::             .||... :|.:|   :..:||
Human   276 F-------VLRSKEGLLDVEK-LECED-------------ELTGTE-ISCLR---LKGQMI---- 311

  Fly   333 NYAPMLKNMYTNITSTKKFHRAKQMGTTLLKNNPNVSN----ERSAIEYYEL-MNNYTDDLRILQ 392
             |.|                   :..:.|...:|:|.|    .|..:...:: :::.|.||.:|.
Human   312 -YLP-------------------EADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLG 356

  Fly   393 KALRRLIK------------EYVDKTLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAAAT---- 441
            :..|...|            :...:.|.:..:|...|....:....|...:::..|::.:|
Human   357 EQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTGCPARIQAFKVQTTLMLCEKDSRSTKGFP 421

  Fly   442 ------IQLYALNLSQKAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDI 500
                  ..|..||                .||:.:||||||.:|:..:.|||:.|:.|||.||.|
Human   422 SISYSGFLLIPLN----------------RLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGI 470

  Fly   501 VGFTEIAADCT-------PLEVVTFLNSIYRVFDERIECYD---VYKVETIGDSYMVASGLPVKN 555
            |||.   |.|:       .:::|..||.:|..||...:...   ||||||:||.||..|||| :.
Human   471 VGFN---AFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLP-EP 531

  Fly   556 GNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTA 620
            ...|...|..:|||:::.:...::   ..|.|||..|:|||.||.|::|.:||||||||:|||..
Human   532 CIHHARSICHLALDMMEIAGQVQV---DGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLT 593

  Fly   621 SRMESTGEAQKIHITEEMHDSLQQVGG----FRTEHRGLIDVKGKGLMSTYW 668
            ||.|:|||..||:::|..:..|.....    |..||||.:.:|||......|
Human   594 SRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVW 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:462453	47/249 (19%)
		CYCc	459..647	CDD:214485	82/197 (42%)
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:462233	11/53 (21%)
		HNOBA	207..449	CDD:462234	58/310 (19%)
		Guanylate_cyc	455..648	CDD:425528	82/198 (41%)