Protein Alignment CG33958 and GUCY1A1

DIOPT Version :9

• Sequence 1: NP_001033958.1
• Gene: CG33958 / 37088
• FlyBaseID: FBgn0053958
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_000847.2
• Gene: GUCY1A1 / 2982
• HGNCID: 4685
• Length: 690
• Species: Homo sapiens
• Alignment Length: 676
• Identity: 174/676 - (25%)
• Similarity: 268/676 - (39%)
• Gaps: 179/676 - (26%)

  Fly    80 SSEDISNGGSGRCCNAAA--------RN-----PAIKTGR-RLQLMQM------IILPFIPILAL 124
            |||:.:  ||...|.|..        :|     |..||.| |:.|..:      :|.|....|.:
Human    29 SSEEAA--GSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNV 91

  Fly   125 IVQTSVTLQEILEYRSAVADIETQVTIATDLGKVVTRLQLERSEVAFYIFTNGSKQRANL----- 184
            .:|.::...:|.|.|.::...:.:.|||.........:::.:..:...:|....::..|:
Human    92 ALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVG 156

  Fly   185 -TLRFANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSRLNEFRDRVRLE-------P 241
             ||:     ..||:.:|..:.|                      |...|...|.|||       .
Human   157 GTLK-----DFLNSFSTLLKQS----------------------SHCQEAGKRGRLEDASILCLD 194

  Fly   242 EESSITEVMNWY----TS-INRGLLHHLSEQIKETD------------------NSGVWRYLVGF 283
            :|.....|..::    || |..|::...:..:.||:                  |.....|.|..
Human   195 KEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHM 259

  Fly   284 KNLLKSIE---------------CQNIATSF-------------GIR-------YYGRGSLTAEN 313
            |:...|:.               |:.....|             |||       :.|:     .|
Human   260 KSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGK-----PN 319

  Fly   314 FVSYVRYEFMAREMINSTLNYAPMLKNMYTNI------TSTKKFHRAKQM----------GTTLL 362
            |..|  :|.:..: ||.|.:....:.||...:      .|.||..|...:          ...|.
Human   320 FEEY--FEILTPK-INQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILF 381

  Fly   363 KNNPNVSNERSAIEYYELMNNYTDDLRILQKALRRLIKEYVDKTLVEADRKEAIGIAILVVVLIV 427
            ..:|.|..    :|.:.....|..|:.| ..|||       |..|:....:...|:
Human   382 LGSPCVDR----LEDFTGRGLYLSDIPI-HNALR-------DVVLIGEQARAQDGL--------- 425

  Fly   428 SPVIIVLVKNAAATIQLYALNLSQKAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEA 492
                    |.....::   ..|.|..:.|:.||:|:..||..:.|..||.||.|.|.|.|:.:..
Human   426 --------KKRLGKLK---ATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSN 479

  Fly   493 VTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGN 557
            ||:.||||||||.|.:.|:||:|:|.||::|..||::....||||||||||:|.||.||. |..:
Human   480 VTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH-KESD 543

  Fly   558 KHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASR 622
            .|..:||.|||.:::.|.....|..  |.:::|.|:|:|.|.||:||.|||||||||:.|..|::
Human   544 THAVQIALMALKMMELSDEVMSPHG--EPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANK 606

  Fly   623 MESTGEAQKIHITEEMHDSLQQVGGF 648
            .||....:||:::...:..|:...||
Human   607 FESCSVPRKINVSPTTYRLLKDCPGF 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	54/323 (17%)
		HNOBA	<439..479	CDD:285003	11/39 (28%)
		CYCc	459..647	CDD:214485	85/187 (45%)
		Guanylate_cyc	485..669	CDD:278633	75/164 (46%)
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	44/228 (19%)
		Guanylate_cyc	472..643	CDD:306677	75/164 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D531253at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820