DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and Adcy8

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_058838.1	Gene:	Adcy8 / 29241	RGDID:	2036	Length:	1248	Species:	Rattus norvegicus

Alignment Length:	828	Identity:	173/828 - (20%)
Similarity:	307/828 - (37%)	Gaps:	241/828 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CPAGGSRMPTP-------SVKIDISTCQSNRPMESRTAPD------------------------- 50
            |.:|   :|.|       .|::.:|..::.|.:.|||..|
  Rat   464 CVSG---LPEPRQDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFD 525

  Fly    51 ----DV---NPSGEGGLLLVPTHHNLQLDKISVRSISSEDISNGGSGRCCNAAARNPAIKTGRRL 108
                ||   |....||   :|  ..:.:.|.::..:|.:.....|.|:..|...|...|:|
  Rat   526 VWSWDVDIANKLESGG---IP--GRIHISKATLDCLSGDYNVEEGHGKERNEFLRKHNIET---- 581

  Fly   109 QLMQMIILPFIPILAL---IVQTSVTLQEILEYRSAVADIETQVTIATDLGKVVTRLQLERSEVA 170
               .:|..|...:|:|   ||:.||:..:                              .|:..|
  Rat   582 ---YLIKQPEESLLSLPEDIVKESVSCSD------------------------------RRNSGA 613

  Fly   171 FYIFTNGSKQRANLTLRFANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSRLN---E 232
              .||.||   .:..|.|.|.....|.:...:..|:...|:.......:.....|...|:.   :
  Rat   614 --TFTEGS---WSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTID 673

  Fly   233 FRDRVRLEPEESSITEVMNWYTSINRGLLHHLSEQIKETDNSG------VWRYLVGFKNLLKSIE 291
            .|...:|..|......:|...:|:.    |..|:...|...|.      |..::...::||.|..
  Rat   674 LRSGDKLRREHIKPFSLMFKDSSLE----HKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSR 734

  Fly   292 CQNIATSFGIRYYGRGSL----TAENF----------VSYVRYEFMAREMINSTLNYAPMLKNMY 342
            ...:...|.|......:|    |||::          ..::...::||.:|    .:|.:|.|..
  Rat   735 LMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVI----IFASILINFL 795

  Fly   343 TNITSTKKFHRAKQMGTTLLKNNP--NVSNERSAI--------EYYELMNNYTDDLRILQKAL-R 396
            ..:.:.        :.....|:.|  |::...||:        ||:.    :|..|.::..|: .
  Rat   796 GAVINI--------LWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFV----FTGVLAMVTCAVFL 848

  Fly   397 RLIKEYVDKTLVEADRKEAIGIAILVVVLIVSPVIIVLV---------------------KNAAA 440
            ||              ...:.:|:|::::.:..::...:                     |.|:.
  Rat   849 RL--------------NSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASL 899

  Fly   441 TIQ----------------------LYALNLSQKAKELKREKRKSDSLLFQMLPPSVAMQL---- 479
            .:.                      |:.:...::..|:|..:..::::|..:||..||...
  Rat   900 LLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKDLREHNENMLRNILPGHVARHFLEKD 964

  Fly   480 KQTQQVPAELYEAVTIYFSDIVGFTEIAADC----TPLEVVTFLNSIYRVFDERI---ECYDVYK 537
            :..:::.::.|:||.:.|:.|.||.:..:..    ..:|.:..||.|...|||.:   ...|:.|
  Rat   965 RDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEK 1029

  Fly   538 VETIGDSYMVASGL-PVKNGNK----HISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGP 597
            ::|||.:||..||| |.|...:    |:..:|..:|.|.:  |:..|.:......::|.|:..|.
  Rat  1030 IKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTE--SIQEINKHSFNNFELRIGISHGS 1092

  Fly   598 VVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKG-- 660
            ||||::|.|.|:|.::|.|||.||||:|||.:.:|.:.||.:..|:. .||..::||.|.|||
  Rat  1093 VVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKD-QGFAFDYRGEIYVKGIS 1156

  Fly   661 --KGLMSTYWLTCKDGPVRAREEISWRADIQPVFLDHLKLHPPTDYKL 706
              :|.:.||:|..:..|             .|..|...:|  |..|.|
  Rat  1157 EQEGKIKTYFLLGRVQP-------------NPFILPPRRL--PGQYSL 1189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	49/270 (18%)
		HNOBA	<439..479	CDD:285003	8/61 (13%)
		CYCc	459..647	CDD:214485	63/203 (31%)
		Guanylate_cyc	485..669	CDD:278633	69/199 (35%)
Adcy8	NP_058838.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269\|PubMed:16258073, ECO:0000269\|PubMed:22494970, ECO:0000269\|PubMed:22976297	1..179
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269\|PubMed:22976297	1..106
		Essential for CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..117
		AC_N	<158..397	CDD:292831
		CYCc	363..561	CDD:214485	19/104 (18%)
		Guanylate_cyc	402..586	CDD:278633	26/136 (19%)
		DUF1053	614..708	CDD:283888	19/100 (19%)
		CYCc	941..1145	CDD:214485	65/206 (32%)
		Guanylate_cyc	970..1169	CDD:278633	70/201 (35%)
		Involved in CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	1106..1248		34/100 (34%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269\|PubMed:19305019	1197..1212
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1220..1248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810