DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_620611.2	Gene:	Gucy2g / 245708	RGDID:	621853	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	276	Identity:	129/276 - (46%)
Similarity:	178/276 - (64%)	Gaps:	20/276 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 VDKTLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAAATIQLYALNLSQKAKE----LKREKRKS 463
            :.|||.||..:..:.|                :.:....:::||.:|.:..:|    |..||||.
  Rat   825 IKKTLREASPRGRVSI----------------LDSMMGKLEMYASHLEEVVEERTCQLVAEKRKV 873

  Fly   464 DSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDE 528
            :.||..|||..|..||...:.|..|.:|:|||:||||||||::.:..:||:||..||.:|.:||.
  Rat   874 EKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDH 938

  Fly   529 RIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGV 593
            .|:.:||||||||||:||||||||::||.:|..|||||:|.||..::.|:|....:|.:::|.|:
  Rat   939 TIQTHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMSLHLLSVTTNFQIGHMPEERLKLRIGL 1003

  Fly   594 HTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDV 658
            ||||||||:||..||||||||||||.||||||:....:||:::....:|...||:..:.||.|.|
  Rat  1004 HTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTARALLVAGGYHLQKRGTISV 1068

  Fly   659 KGKGLMSTYWLTCKDG 674
            ||||..:|:|||.|||
  Rat  1069 KGKGEQTTFWLTGKDG 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564
		HNOBA	<439..479	CDD:285003	15/43 (35%)
		CYCc	459..647	CDD:214485	101/187 (54%)
		Guanylate_cyc	485..669	CDD:278633	100/183 (55%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367
		ANF_receptor	66..417	CDD:279440
		PK_GC	558..832	CDD:270894	3/6 (50%)
		CYCc	868..1058	CDD:214485	102/189 (54%)
		Guanylate_cyc	895..1081	CDD:278633	102/185 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910