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Protein Alignment CG33958 and PHLPP1

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_919431.2	Gene:	PHLPP1 / 23239	HGNCID:	20610	Length:	1717	Species:	Homo sapiens

Alignment Length:	616	Identity:	111/616 - (18%)
Similarity:	204/616 - (33%)	Gaps:	180/616 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 QLDKISVRSISSEDISNGGSGRCC----------------------NAAARNPAIKTGRRLQLMQ 112
            |:.|::.:.|||.|:|      ||                      |...:||::...|.|..:|
Human   630 QVSKVASQRISSVDLS------CCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQ 688

  Fly   113 M------------------IILPFIPILALIVQTSVTLQEILEYRSAVADIETQVTIATDLGKVV 159
            .                  :.:..||.||   :.:|:...:....:||..:....|...| |..:
Human   689 RFTKLKSLNLSNNHLGDFPLAVCSIPTLA---ELNVSCNALRSVPAAVGVMHNLQTFLLD-GNFL 749

  Fly   160 TRLQLERSEVAFYIFTNGSKQRANLTLRFANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRY 224
            ..|..|...:         ||.:.|.|.|
Human   750 QSLPAELENM---------KQLSYLGLSF------------------------------------ 769

  Fly   225 EFQSRLNEFRDRVRLEPEESSITEVMNWYTSINRGLLHHLSEQIKETDNSGVWRYLVGFK----- 284
                  |||.|          |.||:...|::::..   :|....||......|.:...|
Human   770 ------NEFTD----------IPEVLEKLTAVDKLC---MSGNCVETLRLQALRKMPHIKHVDLR 815

  Fly   285 -NLLKSIECQNI-----ATSFGIRYYGRGSLTAENF-----VSYVRYEFMAREMINSTLN--YAP 336
             |:::.:....:     .|...:|....|.|.|..|     :...|.:.:..::....|.  ||.
Human   816 LNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYAS 880

  Fly   337 MLKNMYTNITSTKKFHRAKQMGTTLLKNNPNVSNERSAIEYYELMNNYTDDL--RIL-QKALRRL 398
            ..:.:..::.....:.....:....|:|.|....|...:|..::.:|...:|  |:. ..:||:|
Human   881 SNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKL 945

  Fly   399 IKEYVDKTLVEADRKEAIGIAILVV----VLIVSPVIIVLVK-----NAAATIQLYAL---NLSQ 451
            :..: ::.....:|.|...:.:|.|    :|.:.|.:::...     ||:|. :|.:|   .||:
Human   946 LAGH-NQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASAN-KLESLPPATLSE 1008

  Fly   452 KAKELKREKRKSDSLLFQMLPPSVA---------MQLKQTQQVPA------ELYEAVTIYFSDIV 501
            :...:.:|...:::.|.....|.:.         |...:.|..||      |..|.:.:..:.:.
Human  1009 ETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLK 1073

  Fly   502 GFTEIAADCTPLEVVTFLNSIYRVFDE-----RIECYDVYKVETIGDSYMVASGLPVK------N 555
            .......:|..:..|...::...||.|     .|:|.|:...|.  ....:...||.|      .
Human  1074 AIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNEL--SEVTLPENLPPKLQELDLT 1136

  Fly   556 GNKHISEIATMALDLLDASSVFRI--PRAGD 584
            ||..: .:....|:||:....|:|  |..||
Human  1137 GNPRL-VLDHKTLELLNNIRCFKIDQPSTGD 1166

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.