DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and PHLPP2

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_055835.2	Gene:	PHLPP2 / 23035	HGNCID:	29149	Length:	1323	Species:	Homo sapiens

Alignment Length:	668	Identity:	121/668 - (18%)
Similarity:	221/668 - (33%)	Gaps:	242/668 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 LPFIPILALIVQTSVTLQEILEYRSAVADIETQV-------TIATDLGKVVTRLQLERSEVAFYI 173
            |...|||...:.   ||.|:....:...|:.:|:       |:..| |..:|.|..|...:
Human   311 LGLFPILLCEIS---TLTELNLSCNGFHDLPSQIGNLLNLQTLCLD-GNFLTTLPEELGNL---- 367

  Fly   174 FTNGSKQRANLTLRFANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSRLNEFRDRVR 238
                 :|.::|.:.|       ||.:...|:                   ||..:.|    |||
Human   368 -----QQLSSLGISF-------NNFSQIPEV-------------------YEKLTML----DRV- 396

  Fly   239 LEPEESSITEVM--NWYTSINRGLLHHLSEQIKETD------NSGVWRYLVGFKNL--------- 286
                      ||  |....:|.|:|:.:: .||..|      .:.|...|.|.|::
Human   397 ----------VMAGNCLEVLNLGVLNRMN-HIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNR 450

  Fly   287 -----------LKSIEC------QNIATSFGIR--YYGRGSLTAENFV---SYVRYEFMAREMIN 329
                       |:.:.|      :...:.|.:|  |.....|||.|..   |.:.:..::|.::.
Human   451 LTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLE 515

  Fly   330 STLNYAPMLK---------NMYTNI-------TSTKKFHRAKQMGTTLLKNNPNVSNERSAIEYY 378
            ...::|...|         |:.|.:       .|.:|.    .:|...::|.|.:. |...:|..
Human   516 CVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKL----MLGHNHVQNLPTLV-EHIPLEVL 575

  Fly   379 ELMNNYTDDLRILQKALRRLIKEYVDKTL------VEADRKEAI--------GIAILVVVLIVS- 428
            :|.:|          ||.||......|.|      ..|:..|::        .:::|.::.:.:
Human   576 DLQHN----------ALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNN 630

  Fly   429 -------PV--------IIVLVKNAAATIQLYALNLSQKAKELKREKRKSDSLLFQMLPPSVA-- 476
                   ||        |:.|..|...|.....||..::.:||.....|     .:.:|.::|
Human   631 LLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNK-----LKTIPTTIANC 690

  Fly   477 -------------------MQLKQTQQVPAE--------LYEAV--TIYFSDIVGFTEIAADCTP 512
                               :||.|.|.|...        :.||:  |:...|:.|.|.:..:...
Human   691 KRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKT 755

  Fly   513 LEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDASSVF 577
            |::.:.:.::      :|:...:...::...|...:.||....|.::...::.:|:
Human   756 LDIFSHITTL------KIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKLCVSALAM--------- 805

  Fly   578 RIPRAGDEFVQIRCGVHTGPVVAGIVGTK---MPR--YCLFGDTVNTASRMESTGEAQKIHITEE 637
                  |.|.:   ||  |.|.....|.:   :||  .|...|.:     :|        .:.:.
Human   806 ------DSFAE---GV--GAVYGMFDGDRNEELPRLLQCTMADVL-----LE--------EVQQS 846

  Fly   638 MHDSLQQVGGFRTEHRGL 655
            .:|::.....|...||.|
Human   847 TNDTVFMANTFLVSHRKL 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	53/291 (18%)
		HNOBA	<439..479	CDD:285003	8/60 (13%)
		CYCc	459..647	CDD:214485	34/223 (15%)
		Guanylate_cyc	485..669	CDD:278633	31/186 (17%)
PHLPP2	NP_055835.2	PH_PHLPP-like	149..243	CDD:270131
		LRR 1	250..271
		leucine-rich repeat	253..273	CDD:275380
		LRR 2	273..296
		leucine-rich repeat	274..300	CDD:275380
		LRR 3	300..321		4/9 (44%)
		leucine-rich repeat	301..323	CDD:275380	4/14 (29%)
		LRR_RI	313..606	CDD:238064	70/362 (19%)
		LRR_8	322..380	CDD:290566	15/77 (19%)
		LRR 4	323..344		5/20 (25%)
		leucine-rich repeat	324..346	CDD:275380	4/21 (19%)
		LRR 5	346..368		6/31 (19%)
		leucine-rich repeat	347..369	CDD:275380	6/31 (19%)
		LRR 6	369..390		8/46 (17%)
		leucine-rich repeat	370..416	CDD:275380	17/87 (20%)
		LRR 7	392..412		9/34 (26%)
		LRR 8	416..439		6/22 (27%)
		leucine-rich repeat	418..440	CDD:275380	5/21 (24%)
		LRR 9	440..460		0/19 (0%)
		leucine-rich repeat	442..461	CDD:275380	0/18 (0%)
		LRR 10	461..480		2/18 (11%)
		leucine-rich repeat	462..481	CDD:275380	2/18 (11%)
		LRR 11	481..502		6/20 (30%)
		leucine-rich repeat	482..503	CDD:275380	6/20 (30%)
		LRR 12	503..524		2/20 (10%)
		leucine-rich repeat	504..526	CDD:275380	2/21 (10%)
		LRR 13	526..547		2/20 (10%)
		leucine-rich repeat	527..549	CDD:275380	2/21 (10%)
		LRR_8	549..606	CDD:290566	16/71 (23%)
		LRR 14	549..570		6/25 (24%)
		leucine-rich repeat	550..565	CDD:275380	3/18 (17%)
		LRR 15	571..592		7/30 (23%)
		leucine-rich repeat	572..595	CDD:275380	8/32 (25%)
		LRR 16	595..616		2/20 (10%)
		leucine-rich repeat	596..645	CDD:275380	5/48 (10%)
		LRR 17	621..644		3/22 (14%)
		LRR_8	645..703	CDD:290566	11/62 (18%)
		LRR_4	645..685	CDD:289563	9/44 (20%)
		LRR 18	645..666		5/20 (25%)
		leucine-rich repeat	646..669	CDD:275380	6/22 (27%)
		LRR 19	669..690		5/25 (20%)
		leucine-rich repeat	670..692	CDD:275380	5/26 (19%)
		LRR 20	692..713		1/20 (5%)
		leucine-rich repeat	693..714	CDD:275380	2/20 (10%)
		LRR 21	714..735		5/20 (25%)
		leucine-rich repeat	715..734	CDD:275380	3/18 (17%)
		LRR 22	737..758		5/20 (25%)
		leucine-rich repeat	738..764	CDD:275380	4/25 (16%)
		PP2Cc	784..1033	CDD:238083	21/114 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1157
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900