DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and ADCY4

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001185497.1	Gene:	ADCY4 / 196883	HGNCID:	235	Length:	1077	Species:	Homo sapiens

Alignment Length:	264	Identity:	88/264 - (33%)
Similarity:	138/264 - (52%)	Gaps:	50/264 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 KELKREKRKSDS-------LLFQMLPPSVAMQL----KQTQQVPAELYEAVTIYFSDIVGFTEIA 507
            |:|::|:.::::       ||..:||..||.|.    ::.:.:..:.||.|.:.|:.:..|.|..
Human   822 KKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFY 886

  Fly   508 ADCT----PLEVVTFLNSIYRVFDERI---ECYDVYKVETIGDSYMVASGLPVKNG-------NK 558
            ::..    .||.:..||.|...|||.:   :...|.|::|||.:||.|:||...:|       .:
Human   887 SESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAER 951

  Fly   559 HISEIATMA---------LDLLDASSV--FRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCL 612
            ..|.:.||.         ||:::..|.  ||          :|.|::.||||||::|.:.|:|.:
Human   952 SCSHLGTMVEFAVALGSKLDVINKHSFNNFR----------LRVGLNHGPVVAGVIGAQKPQYDI 1006

  Fly   613 FGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWLT---CKDG 674
            :|:|||.||||||||...||.:|||...:||.: |:....||:|.|||||.:.||:|.   .:.|
Human  1007 WGNTVNVASRMESTGVLGKIQVTEETAWALQSL-GYTCYSRGVIKVKGKGQLCTYFLNTDLTRTG 1070

  Fly   675 PVRA 678
            |..|
Human  1071 PPSA 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564
		HNOBA	<439..479	CDD:285003	9/31 (29%)
		CYCc	459..647	CDD:214485	71/223 (32%)
		Guanylate_cyc	485..669	CDD:278633	74/208 (36%)
ADCY4	NP_001185497.1	AC_N	<115..246	CDD:292831
		CYCc	219..422	CDD:214485
		Guanylate_cyc	264..418	CDD:278633
		DUF1053	479..583	CDD:283888
		CYCc	827..1042	CDD:214485	72/225 (32%)
		Guanylate_cyc	864..1063	CDD:278633	74/209 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810