DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and gcy-27

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001255957.2	Gene:	gcy-27 / 191654	WormBaseID:	WBGene00001550	Length:	616	Species:	Caenorhabditis elegans

Alignment Length:	686	Identity:	176/686 - (25%)
Similarity:	272/686 - (39%)	Gaps:	167/686 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RMPTPSVKIDI---STCQSNRPMESRTAPDDVNPSGE-----GGLLLVPTHHNLQLDKISVRSIS 80
            ::|..|:||.:   :..:..|.:|:|||.|:.|....     |...|:.|.   :.:.|..|.|.
Worm    36 KVPKESLKIIVNKNADARMQRELENRTAKDEANALTSRRRVFGSYALIGTQ---RAEFIQFRQIK 97

  Fly    81 SEDISNGGSGRCCN-AAARNPAIKTGRRLQLMQMIILPFIPILALIVQTSVTLQEILEYRSAVAD 144
            ..||:|.......| ...::..:.....:||..  .|..:.||..:|:.. ||:|....|....|
Worm    98 HIDITNASLDFLYNLKQLKHDNLANFYGIQLND--DLNTMTILHALVERG-TLEEFCLDRDFGMD 159

  Fly   145 IETQVTIATDLGKVVTRLQLERSEVAFYIFTNGSKQRA------NLTLRFA---NTDHALNNMTT 200
            ...:.....|:.|.:..|.|  |.||::    |....|      |..|:.|   .|:...:|...
Worm   160 ETFKSAFMRDILKGLQYLHL--SPVAYH----GHLHAATCLIDINWVLKIALYGVTNFVCDNFDA 218

  Fly   201 WSEISVPTAPDEDEDDREMMLNRYEFQSRLNEFRDRVRLEPEESSITEVMNWYTSINRGLLHHLS 265
             ..|::|     |..|..:...:|            |...|
Worm   219 -ENITMP-----DRSDYTISYAQY------------VCFPP------------------------ 241

  Fly   266 EQIKETDNSGVWRYLVGFKNLLKSIECQNIATSFGIRYYGRGSLTAENF-VSYVRYEFMARE--- 326
            |.|:|.|.:|                  .:.|.|     .|||...:.: |..:.|..:.||
Worm   242 EHIREYDATG------------------KLPTRF-----VRGSKQGDIYCVGMIFYMMIEREDPY 283

  Fly   327 -MINST-------------LNYAPMLKNMYTNITSTKKFHRAKQMGTTLLKNNPNVSNERSAIE- 376
             :|:|.             .|..|.:.|..|.  ......:.|:......:..|.:.|.|:||.
Worm   284 RLIHSVERPGSGLMMEILDHNLMPFISNNETQ--EDTLLDKCKECWNRDPEKRPTIENLRNAIAI 346

  Fly   377 -YYELMNNYTDDLRILQKALRRLIKEYVD--KTLVEADRKEAIGIAILVVVLIVSPVIIVLVKNA 438
             |.:...|..|.       :.|:.::|.|  :|||.|
Worm   347 CYADSKGNLIDQ-------MIRMNEKYADELETLVAA---------------------------- 376

  Fly   439 AATIQLYALNLSQKAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGF 503
                         ::.:|...:.::..||.:|||.|:|..||.....||..|.:.|:.|..|..|
Worm   377 -------------RSADLALAQMQTMRLLNEMLPASIAKDLKNGVIAPARSYASATVMFVQICDF 428

  Fly   504 TEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMAL 568
            ..|.....|.||:.|||.|:..||..|:.:|.|||||.|::||||||:|.:|..:|:.|:|.|:|
Worm   429 IVILKRRPPKEVIGFLNDIFDQFDTVIKRHDAYKVETTGETYMVASGVPNENEGRHVFEVAEMSL 493

  Fly   569 DLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIH 633
            ::...|..:.:....:..:::|.|.|.||:.||::|.|.|||||||||||.||||:|.....:|.
Worm   494 EIRAISLSYTLENDKNYKLRVRIGFHAGPIAAGVIGIKNPRYCLFGDTVNFASRMQSNCPPLQIQ 558

  Fly   634 ITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWL 669
            .:|.....|.....::...||::.|||||.::.|||
Worm   559 TSEITARMLLATHEYKLVKRGIVHVKGKGEVNCYWL 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	48/265 (18%)
		HNOBA	<439..479	CDD:285003	8/39 (21%)
		CYCc	459..647	CDD:214485	76/187 (41%)
		Guanylate_cyc	485..669	CDD:278633	75/183 (41%)
gcy-27	NP_001255957.2	PKc_like	75..338	CDD:304357	64/341 (19%)
		CYCc	383..573	CDD:214485	76/189 (40%)
		Guanylate_cyc	411..595	CDD:278633	77/184 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910