DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and gcy-19

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001348702.1	Gene:	gcy-19 / 191650	WormBaseID:	WBGene00001544	Length:	1187	Species:	Caenorhabditis elegans

Alignment Length:	442	Identity:	154/442 - (34%)
Similarity:	227/442 - (51%)	Gaps:	62/442 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 LLHHLSEQIKETDNSGVWRYLVGFKNLLKSIECQNIATSFGIRYYGRGSLTAENFVSYVRYEFMA 324
            ::..::|.:|...||    :|....||.......|.:....:..:|.|:|..|......|..:||
Worm   678 VIRDMAEGLKYLHNS----FLHVHANLRSGTVLVNESWQAKLTDFGLGTLAEEKKPMKRRQLWMA 738

  Fly   325 REMINSTL--NYAPMLKNMYT-------NITSTKKFHRAKQMGTT------LLKNNPNVSNERSA 374
            .|:|..||  :......::|:       .:|..:.::.|::..|.      :.|..||.......
Worm   739 PEVIRGTLLPHQIEKSADIYSLAVIASEVLTRKEAWNMAERKDTVDEIVYRIKKGGPNAPRPELD 803

  Fly   375 IEYYELMNNYTDDLRILQKALRRLIKEYVDKTLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAA 439
            ::..|:.:|           |..||::...:.  .|||..|             .||..|:||..
Worm   804 MDGVEINHN-----------LLILIRDCWSEE--PADRPSA-------------DVICNLLKNMM 842

  Fly   440 A-----------TIQLYALNL----SQKAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAEL 489
            .           .::.|..||    ..:.|||..||:|:|.||.:|||..||.:|||.|.|..|.
Worm   843 PKKGNLMDHVFNILEDYTTNLEVEVEDRTKELTAEKKKADVLLGRMLPKQVAERLKQGQTVEPEG 907

  Fly   490 YEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVK 554
            :::||::|||:|.||::||.|:|.:||..||.:|..||..||.:..||||:|||.|:..||||.|
Worm   908 FDSVTVFFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDAIIEEHGCYKVESIGDGYLCVSGLPSK 972

  Fly   555 NGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNT 619
            |||.||.:|..::||.:.....|:||....|.|::|.||::||.|||:||..|||||||||||||
Worm   973 NGNAHIKQIVELSLDFMSYCKSFKIPHLPREKVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNT 1037

  Fly   620 ASRMESTGEAQKIHITEEMHDSLQQ--VGGFRTEHRGLIDVKGKGLMSTYWL 669
            ||||||.|:|..||::...:..|.:  ...:.|..||.:.:||||:|.|:|:
Worm  1038 ASRMESNGKASHIHLSAASYTLLMKHYPNQYNTASRGDVIIKGKGVMETFWV 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	28/150 (19%)
		HNOBA	<439..479	CDD:285003	17/54 (31%)
		CYCc	459..647	CDD:214485	98/189 (52%)
		Guanylate_cyc	485..669	CDD:278633	92/185 (50%)
gcy-19	NP_001348702.1	PBP1_NPR_GC_like	45..467	CDD:107347
		PKc_like	571..841	CDD:328722	39/192 (20%)
		CYCc	876..1065	CDD:214485	98/188 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910