DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and gcy-17

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001293327.1	Gene:	gcy-17 / 191649	WormBaseID:	WBGene00001542	Length:	1088	Species:	Caenorhabditis elegans

Alignment Length:	730	Identity:	207/730 - (28%)
Similarity:	322/730 - (44%)	Gaps:	153/730 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PDDVNPS-----GEGGLLLVPTHHNLQLDKISV--RSISSEDISNGGSGRCCNAAARNPAIK--- 103
            ||....|     |.....|..|:..|.::..||  ..:.|:::.:..:||      :.|..|
Worm   405 PDSARTSEIIMIGLNSSRLPETYGKLIINNQSVHFEQLYSDEVMDVWNGR------QRPKAKPTC 463

  Fly   104 --TGRRLQ---LMQMIILPFIPILALIVQTSVTLQEIL-EYRSAVADIETQVTI----ATDLGKV 158
              ||.:..   :...:::..|.::.||...|..:..:. ..|....:||.|..:    |:.|..:
Worm   464 GFTGTQCPPDFVRDYLVIVIIIVMFLIFAVSAAVGAVFYAIRQKRKEIERQDELWHVEASHLKPI 528

  Fly   159 VTRLQLERSEVAFYIFTNGSKQRANLTL-------RF-------------ANTDHALNNMTT--- 200
            ..:   .:||.:...|.:|......||:       ||             |...|......|
Worm   529 SKK---SKSEASQRSFASGPSTSTKLTVESRTETTRFIFYIYQVRNNEVVAANKHDFRPQLTDVE 590

  Fly   201 WSEISVPTAPDEDEDDR--------EMMLNRYEFQSR--LNEFRDRVRLEPEE----SSITEVMN 251
            .||:....:.|.|..::        :.:|:.:.:.||  |.:...|..::.:.    |.|.::.|
Worm   591 RSELRQMRSLDHDNLNKFIGLCLNSQQLLSIWRYCSRGSLADVISRSSMQMDSFFMLSLIRDIAN 655

  Fly   252 WYTSINRGLLHHLSEQIKETDNSGVWRYLVGFKNLLKSIEC------QNIATSFGI-RYYGRGSL 309
            ....|:..:||                    |...|.|..|      |...:.||: ...|...|
Worm   656 GLGFIHTSMLH--------------------FHGYLSSRSCLIDDRWQVKISDFGLNEVRGMDKL 700

  Fly   310 TAENFVSYVRYEFMAREMINSTLNYAPMLKNMYT-NITSTKKFHRAKQMGTTLLKNNPNVSNERS 373
            :.||.:      :.|.|::.. |.......::|: .|..::...|:........|..|...
Worm   701 STENML------WWAPEVLRG-LEQRSKEADIYSFGIICSEVITRSSAFDLENRKEKPEEI---- 754

  Fly   374 AIEYYELMNN---------YTDDLRILQKALRRLIKEY----------VD--KTLVEA--DRKEA 415
               .|:|...         .||:...:..||..||::.          :|  ::|:..  |.|:.
Worm   755 ---IYQLKKGGFNAIRPSLLTDEALEINPALVHLIRDCWTEKPSERPPIDQVRSLLRGMNDGKKG 816

  Fly   416 IGIAILVVVLIVSPVIIVLVKNAAATIQLYALNL----SQKAKELKREKRKSDSLLFQMLPPSVA 476
                             .|:.:....::.||..|    :::.|||..|::|||.||::|||.:||
Worm   817 -----------------NLMDHVFNMLETYASTLEEEVNERTKELVEEQKKSDVLLYRMLPKTVA 864

  Fly   477 MQLKQTQQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETI 541
            .:||....:..|.:|.|||:|||:|.||.:|:.||||:||..||.:|.:||..||..||||||||
Worm   865 EKLKAGISIEPETFELVTIFFSDVVQFTTLASKCTPLQVVQLLNDLYTIFDSIIEQNDVYKVETI 929

  Fly   542 GDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTK 606
            ||.|:..||||.:||:.||..||.|:|..|.:.:.||:.....|.:.:|.|::.|.||||:||..
Worm   930 GDGYLCVSGLPHRNGHDHIKHIARMSLAFLSSLAEFRVAHMPSERINLRIGINCGSVVAGVVGLT 994

  Fly   607 MPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQ-VGGFRTEHRGLIDVKGKGLMSTYWLT 670
            |||||||||.|||||||||.|:..:||::.|.:..|.. |||||||.||.:.:||||:|:||||.
Worm   995 MPRYCLFGDAVNTASRMESNGKPGRIHVSSEANHLLTHVVGGFRTEERGEVIIKGKGVMNTYWLL 1059

  Fly   671 CKDGPVRAREEISWR 685
            .::..|..:..:..|
Worm  1060 GENDSVPVKSNMRKR 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	50/290 (17%)
		HNOBA	<439..479	CDD:285003	17/43 (40%)
		CYCc	459..647	CDD:214485	98/188 (52%)
		Guanylate_cyc	485..669	CDD:278633	100/184 (54%)
gcy-17	NP_001293327.1	Periplasmic_Binding_Protein_Type_1	25..404	CDD:299141
		ANF_receptor	47..398	CDD:279440
		PKc_like	539..808	CDD:304357	53/302 (18%)
		Pkinase	567..803	CDD:278497	46/269 (17%)
		HNOBA	<824..867	CDD:285003	17/42 (40%)
		CYCc	846..1038	CDD:214485	100/191 (52%)
		Guanylate_cyc	873..1060	CDD:278633	102/186 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910