Protein Alignment CG33958 and gcy-15

DIOPT Version :10

• Sequence 1: NP_001033958.1
• Gene: CG33958 / 37088
• FlyBaseID: FBgn0053958
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_001364713.1
• Gene: gcy-15 / 191648
• WormBaseID: WBGene00001541
• Length: 1104
• Species: Caenorhabditis elegans
• Alignment Length: 709
• Identity: 207/709 - (29%)
• Similarity: 322/709 - (45%)
• Gaps: 166/709 - (23%)

  Fly    61 LLVPTHHNLQLDKISVRSISS-------------------EDISNGGSGRCCNAAARNPAIKTGR 106
            :::..|.|| :.:.|:||::|                   ||.:|..|   .||::   ...||.
 Worm   475 IILKKHTNL-MSQQSLRSMASIHGSVVAASQTLRDSHFFIEDYNNASS---INASS---IFNTGS 532

  Fly   107 RLQLMQMIILPFIPILALIVQTSVTLQE----ILEYRSAVADIETQVTIATDLGKVVTRLQLERS 167
            ..:..     ||.||......|..:..|    |.::...:.:           |:.|...::.||
 Worm   533 TARAG-----PFGPIPGFGGVTGASEDEKWHQIPDFGVGLYE-----------GRTVALKRIYRS 581

  Fly   168 EVAFYIFTNGSKQRANLTLRFANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSRLNE 232
            :|.|        .|:| .|..|....::|:........|..:||        :...||...| ..
 Worm   582 DVEF--------TRSN-RLEIAKLQESVNSNVIEFVGMVVQSPD--------VFVVYELAQR-GS 628

  Fly   233 FRDRVRLEPEESSITEVMNWYTSINRGLLHHLSEQIKETDNSGVWRYL----VGFKNLLKSIECQ 293
            .:|  .|:.::..:.:|..              .|:.:...:|: .||    ||....|||..|.
 Worm   629 LKD--ILDNDDMPLDDVFR--------------SQMTKDIIAGL-EYLHSSPVGCHGRLKSTNCL 676

  Fly   294 NIA------TSFGIRYYGRGSLT--AENFVSYVRYEFMAREMINSTLNYAPMLKNMYTNITSTKK 350
            ..|      :|||:|.. ||..|  .|:.|...:.:...          :|.|....|.::
 Worm   677 IDARWMVRLSSFGLREL-RGEETWQQEDDVQEGKDQLWT----------SPELLRWSTGLS---- 726

  Fly   351 FHRAKQMGTTLLKNNPNVSNERSAIEYYELMNN----------------------------YTDD 387
                 |.|..|::.:...|   .||..|||...                            :..|
 Worm   727 -----QCGVLLVQKSDVYS---LAIVLYELFGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPD 783

  Fly   388 LRILQKALRRLIKEYVDKTLVEADRKEAIGIAIL-VVVLIVSPVII----VLVKNAAATIQLYA- 446
            :.:|:::.|     .|.:|:|.|..::.:....| .:...:.|:.|    .::.|..:.|:.|.
 Worm   784 MAVLKESPR-----IVQETVVAAWTEDPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTD 843

  Fly   447 ---LNLSQKAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEIAA 508
               .:::::.:||:.||.||::||..|||..||..||....|.||.:|..|::|||..||.|::|
 Worm   844 KLEKDIAERNEELEAEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSA 908

  Fly   509 DCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDA 573
            ...|:::|.|||.:|.|||..|:.:||||||||.|:|||||||||.|||.|..|||::.|.||.|
 Worm   909 TSKPIDIVQFLNDLYTVFDRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALLKA 973

  Fly   574 SSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEM 638
            ...|:|....:|.|::|.|:::||.|||:||.||||||||||||||||||||.|...:|:.:...
 Worm   974 VESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTA 1038

  Fly   639 HDSLQQVGGFRTEHRGLIDVKGKGLMSTYWLTCKDGPVR----AREEISW----RADIQ 689
            .:.|.|:||:..|.||::::||||...||::..::..:|    .||.:.:    :|.||
 Worm  1039 KEILDQLGGYEIEERGIVEMKGKGKQMTYFVRGENSDMRRERIIRERVKFASLKKAQIQ 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:462453	53/276 (19%)
		CYCc	459..647	CDD:214485	101/187 (54%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:471960
		PK_GC	553..822	CDD:270894	62/342 (18%)
		HNOBA	<831..879	CDD:462234	16/47 (34%)
		Guanylate_cyc	885..1071	CDD:425528	99/185 (54%)