DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and gcy-15

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001364713.1	Gene:	gcy-15 / 191648	WormBaseID:	WBGene00001541	Length:	1104	Species:	Caenorhabditis elegans

Alignment Length:	709	Identity:	207/709 - (29%)
Similarity:	322/709 - (45%)	Gaps:	166/709 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LLVPTHHNLQLDKISVRSISS-------------------EDISNGGSGRCCNAAARNPAIKTGR 106
            :::..|.|| :.:.|:||::|                   ||.:|..|   .||::   ...||.
Worm   475 IILKKHTNL-MSQQSLRSMASIHGSVVAASQTLRDSHFFIEDYNNASS---INASS---IFNTGS 532

  Fly   107 RLQLMQMIILPFIPILALIVQTSVTLQE----ILEYRSAVADIETQVTIATDLGKVVTRLQLERS 167
            ..:..     ||.||......|..:..|    |.::...:.:           |:.|...::.||
Worm   533 TARAG-----PFGPIPGFGGVTGASEDEKWHQIPDFGVGLYE-----------GRTVALKRIYRS 581

  Fly   168 EVAFYIFTNGSKQRANLTLRFANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSRLNE 232
            :|.|        .|:| .|..|....::|:........|..:||        :...||...| ..
Worm   582 DVEF--------TRSN-RLEIAKLQESVNSNVIEFVGMVVQSPD--------VFVVYELAQR-GS 628

  Fly   233 FRDRVRLEPEESSITEVMNWYTSINRGLLHHLSEQIKETDNSGVWRYL----VGFKNLLKSIECQ 293
            .:|  .|:.::..:.:|..              .|:.:...:|: .||    ||....|||..|.
Worm   629 LKD--ILDNDDMPLDDVFR--------------SQMTKDIIAGL-EYLHSSPVGCHGRLKSTNCL 676

  Fly   294 NIA------TSFGIRYYGRGSLT--AENFVSYVRYEFMAREMINSTLNYAPMLKNMYTNITSTKK 350
            ..|      :|||:|.. ||..|  .|:.|...:.:...          :|.|....|.::
Worm   677 IDARWMVRLSSFGLREL-RGEETWQQEDDVQEGKDQLWT----------SPELLRWSTGLS---- 726

  Fly   351 FHRAKQMGTTLLKNNPNVSNERSAIEYYELMNN----------------------------YTDD 387
                 |.|..|::.:...|   .||..|||...                            :..|
Worm   727 -----QCGVLLVQKSDVYS---LAIVLYELFGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPD 783

  Fly   388 LRILQKALRRLIKEYVDKTLVEADRKEAIGIAIL-VVVLIVSPVII----VLVKNAAATIQLYA- 446
            :.:|:::.|     .|.:|:|.|..::.:....| .:...:.|:.|    .::.|..:.|:.|.
Worm   784 MAVLKESPR-----IVQETVVAAWTEDPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTD 843

  Fly   447 ---LNLSQKAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEIAA 508
               .:::::.:||:.||.||::||..|||..||..||....|.||.:|..|::|||..||.|::|
Worm   844 KLEKDIAERNEELEAEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSA 908

  Fly   509 DCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDA 573
            ...|:::|.|||.:|.|||..|:.:||||||||.|:|||||||||.|||.|..|||::.|.||.|
Worm   909 TSKPIDIVQFLNDLYTVFDRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALLKA 973

  Fly   574 SSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEM 638
            ...|:|....:|.|::|.|:::||.|||:||.||||||||||||||||||||.|...:|:.:...
Worm   974 VESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTA 1038

  Fly   639 HDSLQQVGGFRTEHRGLIDVKGKGLMSTYWLTCKDGPVR----AREEISW----RADIQ 689
            .:.|.|:||:..|.||::::||||...||::..::..:|    .||.:.:    :|.||
Worm  1039 KEILDQLGGYEIEERGIVEMKGKGKQMTYFVRGENSDMRRERIIRERVKFASLKKAQIQ 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	53/276 (19%)
		HNOBA	<439..479	CDD:285003	15/43 (35%)
		CYCc	459..647	CDD:214485	101/187 (54%)
		Guanylate_cyc	485..669	CDD:278633	99/183 (54%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:415822
		PK_GC	553..822	CDD:270894	62/342 (18%)
		HNOBA	<831..879	CDD:400168	16/47 (34%)
		Guanylate_cyc	885..1071	CDD:306677	99/185 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910