DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and gcy-4

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_496218.2	Gene:	gcy-4 / 191642	WormBaseID:	WBGene00001531	Length:	1136	Species:	Caenorhabditis elegans

Alignment Length:	727	Identity:	202/727 - (27%)
Similarity:	307/727 - (42%)	Gaps:	200/727 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 NLQLDKISVRSIS-SEDISN----------------GGS-----------GRCCNAAARNPAIKT 104
            |.:.|:||:..|| ..|..|                ||:           |:.|..    |..:.
Worm   423 NSEYDQISLIDISLINDTVNVVFNYADGNTEVWHFWGGTRPPDTPVCGFLGKSCPL----PIFEQ 483

  Fly   105 GRRLQLMQMIILPFIPILALIVQTSVTLQEILEYRSAVADIETQVTIATDLGKVVTRLQLER--- 166
            .|.|.::.:.:...| :||:|:..|   .:|...|...:.:.::..|..    :..||.:.|
Worm   484 YRALVIVAIAVTILI-LLAIIICMS---SKIRNRRVEQSRLHSEWQIHA----IKLRLPMHRRAS 540

  Fly   167 -----------SEVAFYIFTNG----SKQRANLTLRFANTDHALNNMTTWSEISVPTAPDEDEDD 216
                       ||...:...:|    |:.:...|:::...|..|.......|:|          .
Worm   541 KSSQESETESASETENFTSKSGDTMTSEFKETYTIQYLENDLVLTTAHQVQELS----------Q 595

  Fly   217 REMM----LNRYEFQSRLNEFRDRVRLEPEESSITEVMNWYTS------INRG-----------L 260
            .|||    |.:.:.:: ||:|   :.|..:.|....|....:.      |::|           :
Worm   596 AEMMKFVKLRKLDHEN-LNKF---IGLSIDGSRFVSVWKMCSRGSLQDIISKGSFSMDYFFMFCM 656

  Fly   261 LHHLSEQIKETDNSGVWRYLVGFKNLLKSIEC------QNIATSFGIRYYG-------------- 305
            :..::|.:.....|    :|....| |:|..|      |.....||:::..
Worm   657 IRDIAEGLHYIHKS----FLRHHGN-LRSATCLVNDSWQVKLADFGLQFLQDEEEKPFKKNMLWA 716

  Fly   306 -----RGSLTAENFVSYVR-YEF--MAREMINSTLNY-APMLKNMYTNIT-STKK---------F 351
                 ||||:.|...|... |.|  :|.|::.....: ....|..|..|. :.||         .
Worm   717 APEVIRGSLSIEQMDSSADIYSFAIVASEILTKREAWDLSRRKEGYEEIKYAVKKGGQFVLRPDL 781

  Fly   352 HRAKQMGTTLLK-------NNPNVSNERSAIE-----YYELMNNYTDDLRILQKALRRLIKEYVD 404
            |...::..|||.       .||   .||.:.|     .:::..|..|:   |...:..:::||..
Worm   782 HIDIEVNQTLLALVKDCWCENP---EERPSAENVCKVLFDMTPNTEDN---LMDHVFSMLEEYTS 840

  Fly   405 KTLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAAATIQLYALNLSQKAKELKREKRKSDSLLFQ 469
            ...||                                       :.::.|||..||:|||.||.:
Worm   841 SLEVE---------------------------------------VGERTKELTLEKKKSDILLGR 866

  Fly   470 MLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYD 534
            |||..||.:||..|.|..|.::.||::|||:|.||::|:.|:|.:||..||.::..||..||.:|
Worm   867 MLPKQVAERLKAGQAVEPESFDLVTVFFSDLVKFTDLASKCSPFQVVNLLNDVFSNFDSIIEKHD 931

  Fly   535 VYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVV 599
            |||||:|||.::..||||.:||.:||.:|..|:|..::....||||....|.|::|.|:::||.|
Worm   932 VYKVESIGDGFLCVSGLPNRNGMEHIRQIVGMSLCFMEFCRNFRIPHLPRERVELRVGINSGPCV 996

  Fly   600 AGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGG----FRTEHRGLIDVKG 660
            ||:||..|||||||||||||||||||.|:...||::|..|..|  |..    |.|..||.:.:||
Worm   997 AGVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLL--VNNYPYQFETNSRGEVIIKG 1059

  Fly   661 KGLMSTYWLTCK 672
            ||:|.||||..|
Worm  1060 KGVMETYWLLGK 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	61/326 (19%)
		HNOBA	<439..479	CDD:285003	15/39 (38%)
		CYCc	459..647	CDD:214485	97/187 (52%)
		Guanylate_cyc	485..669	CDD:278633	93/187 (50%)
gcy-4	NP_496218.2	PBP1_NPR_GC_like	29..457	CDD:107347	8/33 (24%)
		ANF_receptor	49..423	CDD:279440	202/727 (28%)
		PKc_like	558..819	CDD:304357	53/282 (19%)
		HNOBA	<834..876	CDD:285003	19/80 (24%)
		CYCc	855..1047	CDD:214485	97/193 (50%)
		Guanylate_cyc	882..1070	CDD:278633	95/189 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910