DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and phlp-2

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001337270.1	Gene:	phlp-2 / 185690	WormBaseID:	WBGene00009647	Length:	1126	Species:	Caenorhabditis elegans

Alignment Length:	735	Identity:	129/735 - (17%)
Similarity:	232/735 - (31%)	Gaps:	250/735 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 VQTSVTLQEILEYRSAVADIETQVTIATDLGKVVTRLQLERSEVAFYIFTNGSKQRANLTLRFAN 190
            :||.....|.|:.|:...|:..        .|....|:|:..:|.:.|..    ||.|:...:..
Worm   170 LQTKNNQDEALQIRNMKVDVHE--------SKRGRALRLKDDDVCYLIIF----QRPNILEAWLT 222

  Fly   191 TDHAL--NNMTTWSEISVPTAPDE--DEDDREMMLN--RYEFQSR---------LNEFRDRVR-- 238
            ....:  :|....|:..:...|::  :.:.|..:||  |....||         |....|..|
Worm   223 RAQQVEKSNHVDASDEQLTLIPEQILNNEARVQILNLRRNSLISRPPTEKSMAPLGYIDDLYRVH 287

  Fly   239 -LEPEESSITEVMNWYTSINRGLLHHLSEQIKETDNSGVWRYLVGFKNLLKSI--ECQNIATSFG 300
             |:..:.|..:::::  .|...||.||             |.|....|.:.|:  ||.|:.
Worm   288 SLQVIDLSANQILSF--PIQLTLLSHL-------------RQLNLSSNYISSVPSECSNMR---- 333

  Fly   301 IRYYGRGSLTAENFVSYVRYEFMAREMINSTLNYAPMLKNMYTNITSTK-KFHRAKQMGTTLLKN 364
                              |.:::  .:.|:.|:..|...:...|:.|.. .|::..|:...|.
Worm   334 ------------------RLQYL--NLSNNQLDTLPDSISELQNLQSLDISFNQFSQIPPCLF-- 376

  Fly   365 NPNVSNERSAIEYYELMNNYTD-------------DLR--ILQKALRRLIKEYVDKTLVEADRKE 414
                   ...:|.:.|..|..:             |||  :|..:.|..|:......|.:.....
Worm   377 -------HLTLEMWRLAGNNIEKIDRVGEMQIQKIDLRRNVLDTSFRLDIENITHLDLRDNSMIS 434

  Fly   415 AIGIAILVVVLIVSPVIIVLVKNAAATIQLYALNLS-QKAKELKREKRKSDSLLFQMLPPSVAMQ 478
            .:.:..|..:.::.          ...:||.:|:|| :....:..:....|||:...||.::
Worm   435 TVHLTNLRFLKVIH----------CERLQLSSLHLSGESLTHVYADHNLLDSLVVMPLPQNL--- 486

  Fly   479 LKQTQQVPAELYEAVTIYFSDIVGFTEIAADCTPL--------------EVVTFLNSIYRV--FD 527
              ||..:....:..:..:.||....|.:.|:...|              .:..|:|.|..:  |.
Worm   487 --QTLSLSFNHFRNLPDWISDCPNLTFLRANNNSLVALPERIFYSQSLRSIFAFINEIEHIPDFG 549

  Fly   528 ER--IECYDVYK--------------------------VETI----------------GDSYMVA 548
            |.  :|...:||                          :|.:                .::|:..
Worm   550 EENCLETLILYKNKLSSLPKHFFSILPRLRQLNISSNFIELLPYFDGSSFCRLQILRCANNYLTE 614

  Fly   549 SGLPVKNGNKHISEI-------------ATMALDLLDASSVF--RIPRAGDEFVQIRC------- 591
            :.:||....||:..|             |..:|:||:..::.  |:.|..|....:.|
Worm   615 NSVPVIVNMKHLKIIDLSHNRLNSFDDSALSSLELLEDLNLSSNRLTRLADCLALLPCLQVLRAH 679

  Fly   592 -------------------GVHTGPVVAGIVGTKMP---RY----CLFG--DTVNTASRMESTGE 628
                               .|.:..:..|.:..|.|   |:    |..|  ||.|.....:...:
Worm   680 SNQLVHVPEFRASNQLHTIDVSSNNISLGTLQFKAPPNLRHFDVTCNSGDFDTENFPENAKMHSK 744

  Fly   629 AQKIHITEEMHDSLQQVGGF-------------------RTEHR-GLIDVKGKGLMSTYWLTCKD 673
            ...|:|:|    ..|.:.||                   |.|:. |.||......||:  ..|:.
Worm   745 MNTINISE----GSQNLFGFQIGVSGSRGMKNKQCIRQVRVENTFGFIDGGSNSYMSS--SICRF 803

  Fly   674 GPVRAREEISWRADIQPVFL 693
            .....:|.:|  .||:.:.|
Worm   804 MTSYLKENVS--MDIRSILL 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	49/272 (18%)
		HNOBA	<439..479	CDD:285003	10/40 (25%)
		CYCc	459..647	CDD:214485	49/297 (16%)
		Guanylate_cyc	485..669	CDD:278633	51/313 (16%)
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380	2/20 (10%)
		leucine-rich repeat	254..288	CDD:275380	8/33 (24%)
		PLN00113	283..>718	CDD:331614	79/497 (16%)
		leucine-rich repeat	289..311	CDD:275380	5/23 (22%)
		leucine-rich repeat	312..334	CDD:275380	8/56 (14%)
		leucine-rich repeat	335..357	CDD:275380	3/23 (13%)
		leucine-rich repeat	358..379	CDD:275380	4/29 (14%)
		leucine-rich repeat	380..440	CDD:275380	10/59 (17%)
		leucine-rich repeat	441..485	CDD:275380	11/53 (21%)
		leucine-rich repeat	486..508	CDD:275380	4/26 (15%)
		leucine-rich repeat	509..534	CDD:275380	3/24 (13%)
		leucine-rich repeat	554..577	CDD:275380	3/22 (14%)
		leucine-rich repeat	578..602	CDD:275380	1/23 (4%)
		leucine-rich repeat	603..625	CDD:275380	3/21 (14%)
		leucine-rich repeat	626..649	CDD:275380	3/22 (14%)
		leucine-rich repeat	650..672	CDD:275380	4/21 (19%)
		leucine-rich repeat	673..694	CDD:275380	0/20 (0%)
		PP2Cc	754..985	CDD:214625	16/72 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900