DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and acy-4

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_504486.4	Gene:	acy-4 / 178949	WormBaseID:	WBGene00000071	Length:	1013	Species:	Caenorhabditis elegans

Alignment Length:	632	Identity:	151/632 - (23%)
Similarity:	259/632 - (40%)	Gaps:	163/632 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 VTIATDL------GKV----VTRLQLERSEVAFYIFTNGSKQRANLTLRFANTDHALNNMTTWSE 203
            ||:|..:      |:|    .||..|:.:    ||...|:   .....:|...:    .:.||
Worm   422 VTLANQMESGGLAGRVHITDATRSYLKGA----YILEEGN---GGSRSKFLEKE----KIKTW-- 473

  Fly   204 ISVPTAPDEDEDDRE-----MML-----NRYEFQSRLNEFRDRVR-------LEPEESSITEVMN 251
            :.|..:||.|...:|     :|:     .....|.||.....|.|       |..||..:..|.:
Worm   474 LVVDRSPDYDNICQEATNHPVMVPWKSTRGISKQERLTGMSTRTRGASTRNGLSEEEVLVENVDS 538

  Fly   252 WYTSINRGLLHHLSEQIKETDNSGVWRYLVGFKNLLKSIECQNIATSFGIRYYGRGSLTAENFVS 316
                       ||.:.|:...... |          |::.|:|    :.::|   ..:..||...
Worm   539 -----------HLRQGIQAIHQEN-W----------KTMHCKN----WSLKY---KQVRVENKFV 574

  Fly   317 YVRYE--------FMAREMINSTLNYAPM-------LKNMYTNITSTKKFHRAKQMGTTLLKNNP 366
            .::|:        ::|...|...:.:..|       :..|:..:||...|...:    .|:|:..
Worm   575 RLKYKDIPFQVTLYVAIVAICIGIKFGLMNLVSFSFVPQMFIVLTSVMIFILTR----ALIKHAR 635

  Fly   367 NVSNERS------AIEYYELM----------------NNYTDDLRILQ----------------K 393
            .||....      :|:...||                |||||...|.:                |
Worm   636 LVSLVIGVLFILLSIQIVILMGMYESKFTCDVEKCFKNNYTDFFEIFEICTLATCVILSVDFMTK 700

  Fly   394 ALRRLI-----KEYVDKTLVEADRKEAI--GIAILVVVLIVSPVIIVLVKNAAATIQLY----AL 447
            .|..:|     ...:...|:..::.||:  ..|...|:..::.:::|.....:..|..|    .|
Worm   701 LLMSMIYFSSFTVLITAKLIRINQYEALLSTYANFCVLSCLTLLLVVFSTRRSELISRYDFIWKL 765

  Fly   448 NLSQKAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELY----EAVTIYFSDIVGFTEIAA 508
            ....:..::||:..::.|:|..:||..||....:.....::||    :...|.|:.:..|.:...
Worm   766 QALDEQLQMKRKHEQNRSVLENILPSHVAKHFVEDATSVSKLYHESRDNACIMFATLTEFDKFYI 830

  Fly   509 DC----TPLEVVTFLNSIYRVFD-------ERIECYDVYKVETIGDSYMVASGLPVK--NGNKHI 560
            :|    ..:|.:..||.|...||       :|.|...:.|::||..:|||||||..:  ..|.|:
Worm   831 ECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKIEKIKTISTTYMVASGLAGRECGDNSHV 895

  Fly   561 SEIATMALDL---LDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASR 622
            ..||..|.:|   |:::::    .:.:.| .:|.|::.||||||::|:..|.|.::|::||.|||
Worm   896 EAIALFARELLVKLESTNI----HSFNNF-NLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVASR 955

  Fly   623 MESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWL 669
            |:|.|.|.:|.:|||:...|:.: |:..|.||.|:|||||:|.|::|
Worm   956 MDSGGVAGRIQVTEEVKSILEPL-GYNFECRGQINVKGKGMMETFFL 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	56/306 (18%)
		HNOBA	<439..479	CDD:285003	11/43 (26%)
		CYCc	459..647	CDD:214485	64/207 (31%)
		Guanylate_cyc	485..669	CDD:278633	70/203 (34%)
acy-4	NP_504486.4	AC_N	<50..291	CDD:292831
		CYCc	260..451	CDD:214485	8/32 (25%)
		Guanylate_cyc	293..448	CDD:278633	7/25 (28%)
		CYCc	778..984	CDD:214485	65/211 (31%)
		Guanylate_cyc	807..1003	CDD:278633	71/201 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810