DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and gcy-18

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_502449.2	Gene:	gcy-18 / 178237	WormBaseID:	WBGene00001543	Length:	1113	Species:	Caenorhabditis elegans

Alignment Length:	686	Identity:	197/686 - (28%)
Similarity:	284/686 - (41%)	Gaps:	200/686 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 HHNLQ-LDKISVRSISS-----EDISNGGSGRCCNA-------------AARNPA--IKTGRRL- 108
            |.:|| :|:..|:|:.|     ..:||..:|:..:|             ..|.|.  ||...:|
Worm   537 HDDLQFIDEEQVKSMMSVGSVTTKLSNIQTGQKQHAIIGVNTHTTYHRYKQRRPIKFIKEDMQLL 601

  Fly   109 -QLMQMI---ILPFI--------PILALIVQTS-VTLQEILEYRSAVADIETQVTIATDLGKVVT 160
             |:.|.:   :.||:        .:|.|....| .|:|:|:...:.|.|.:.......|:
Worm   602 TQMKQAVHDNLNPFLGAAFNEKEEMLVLWKFCSRGTIQDIIYNANVVLDEKFHGAFVRDI----- 661

  Fly   161 RLQLERSEVAFYIFTNGSKQRANLT----LRFAN-----TDHAL-NNMTTWSE---ISVPTAPDE 212
            .|.||      |:..:......:||    |...|     :|:.: |.:..|.:   |.:..|.|.
Worm   662 TLGLE------YLHASPIGYHGSLTPWCCLIDRNWMVKLSDYGIANPLERWEKQGAIEIAAAKDS 720

  Fly   213 DEDDREMMLNRYEFQSRLNEFRDRVRLEPEESSITEVMNWYTSINRGLLHHLSEQIKETDNSGVW 277
            |:            :|:.::....:.:.||     .:.|..|:..||:           |.|.|
Worm   721 DD------------KSQASQATSIIYMAPE-----LLKNRETNKRRGM-----------DQSWV- 756

  Fly   278 RYLVGFKNLLKSIECQNIATSFGIRYYGRGSLTAENFVSYVRYEFMAREM-------INSTLNY- 334
                  |..:...:..:| .|||:                |.||.:.|.:       |:..::|
Worm   757 ------KQSMLRRQAGDI-YSFGM----------------VMYEILFRSLPFRDNTNISELVDYL 798

  Fly   335 -------APMLKNMYTNITSTKKFHRAKQMG-----TTLLKN----NPNVSNERSAIEYYELMNN 383
                   :|.::|               |||     ..||::    ||.:   |.:|.
Worm   799 ADGSKTVSPEIQN---------------QMGLHPDLNALLRDCWSENPEI---RPSIR------- 838

  Fly   384 YTDDLRILQKALRRLIKEYVDKTLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAAATIQLYALN 448
                 |:      ||..|.|.||...                        ||......::.||.|
Worm   839 -----RV------RLNTEMVLKTKGS------------------------LVDQMMKMMEQYANN 868

  Fly   449 LSQKAKE----LKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEIAAD 509
            |.:...|    |:....::|.||.|:||..||.:||..:.|..:||.:.||.||||||||.|.:.
Worm   869 LEKLVAERTGMLEEANIRADQLLTQLLPAYVANELKMGRSVAPKLYSSATILFSDIVGFTTICSG 933

  Fly   510 CTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDAS 574
            .||||||..||.:|..|||.|.....||||||||:|||.||:|.:|...|...||..|||:....
Worm   934 STPLEVVNMLNGLYTGFDECITRNKSYKVETIGDAYMVVSGIPEENEYNHSRNIANTALDMRQYL 998

  Fly   575 SVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMH 639
            :.::||......|:.|.|.|||.|.||:||...|||||||||||.:|||||||....|.::||.|
Worm   999 TGYQIPHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEEAH 1063

  Fly   640 DSLQ-QVGGFRTEHRGLIDVKGKGLMSTYWLTCKDG 674
            ..:: ....|.|..||.:.|||||...|:||..:.|
Worm  1064 MHIRAHHPVFTTTERGEVQVKGKGTCRTFWLEDRVG 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	48/273 (18%)
		HNOBA	<439..479	CDD:285003	14/43 (33%)
		CYCc	459..647	CDD:214485	93/188 (49%)
		Guanylate_cyc	485..669	CDD:278633	93/184 (51%)
gcy-18	NP_502449.2	Periplasmic_Binding_Protein_Type_1	87..448	CDD:299141
		ANF_receptor	87..395	CDD:279440
		PKc_like	549..846	CDD:304357	74/395 (19%)
		HNOBA	<857..903	CDD:285003	14/45 (31%)
		CYCc	882..1073	CDD:214485	93/190 (49%)
		Guanylate_cyc	909..1095	CDD:278633	94/185 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910