DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and gcy-12

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_494995.2	Gene:	gcy-12 / 173902	WormBaseID:	WBGene00001538	Length:	1679	Species:	Caenorhabditis elegans

Alignment Length:	763	Identity:	210/763 - (27%)
Similarity:	304/763 - (39%)	Gaps:	243/763 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PTHHNLQLDKISVRSISSEDISN----------------------GGSGRCCNAAARNPAIKTGR 106
            |..|.|.|..|.|.:...:.:.|                      |..|..|    |...|
Worm   538 PLDHALDLTAIFVEAPDKDRLPNLQFKSSRIQWLKGEPPPDEPVCGFHGENC----RKKGI---- 594

  Fly   107 RLQLMQMIILPFIPILALIVQTSVTLQEI-----------------LEYRSAVADIETQVTIATD 154
             ...:.::::..|.:.:|:: |..||..|                 .|.|..|..:..:.|.:
Worm   595 -FSYLTVVVMILIAVFSLVL-TGFTLNYIRSRRFEKELSMIWKIDPYEVRRVVGGVNNESTAS-- 655

  Fly   155 LGKVVTRLQLERSEVAFYIFTNGSKQRANLTLRFANTDHALNNMTTW------------------ 201
                     |.:|:|                ::||.|      .|.|
Worm   656 ---------LMQSDV----------------MQFAKT------KTPWWSKAPVQGTGMRGLASYK 689

  Fly   202 ------SEISVPTAPDE--DEDDREMMLNRYEFQSRLNEFRDRVRLEPEESSITEVMNWYTSINR 258
                  .::.....|.:  .|..:|:...|......:|.|...:..   :.|:|.|..:   .::
Worm   690 GTLVGLKDLMYGRKPKDLTREAKKELRAMRQLAHPNVNNFLGIIVC---QYSVTVVREY---CSK 748

  Fly   259 GLLHHL--SEQIKETDNSGVWRYLVGF-----KNL-------------LKSIECQNIATS----- 298
            |.||.:  :|.:| .|:    .|:..|     |.:             |||..|  :.||
Worm   749 GSLHDILRNENLK-LDH----MYVASFVDDLVKGMVYIHDSELKMHGNLKSTNC--LITSRWTLQ 806

  Fly   299 ---FGIRYYGRGSLTAENFVSYVRYEFMAREMINSTLNYAPMLKNMYTNITSTKK----FHRA-- 354
               ||:|....|.:...::..:..:.:.|.|.:  |:|.:..:.|..|.......    ||..
Worm   807 IADFGLRELREGIMYDSSYNIWENFLWTAPEAM--TINGSLAISNPPTPKADAYSFGIIFHEIFT 869

  Fly   355 --------KQMGTTLLKNNPNVSNERSAIEYYELMNNYTDDLRILQKALRRL------------- 398
                    .|.|..    |...:.::.::|...|          ::|.:||:
Worm   870 REGPYKIYVQRGDV----NGEAAPKKDSVECRAL----------VEKTVRRVYSDPYFRPDTSDL 920

  Fly   399 -IKEYVDKTLVEA------DRKEAIGIAILVVVLIVSPVIIVLVKNAAATI--QLYALNL----- 449
             ::.||.:.:...      .|.|                 ...:||....:  |:|..|:
Worm   921 EVQNYVKEVMAACWHHDPYQRPE-----------------FKTIKNKLKPLFHQIYKQNIMDHMV 968

  Fly   450 --------------SQKAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDI 500
                          .::..|||.|:|:|..||.:|||.|||.||...|.|..|.:..||||||||
Worm   969 LMMEKYQTQLEDLVDERTIELKDEQRRSQHLLQRMLPSSVAEQLLAGQDVIPEAFPPVTIYFSDI 1033

  Fly   501 VGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLP-VKNGNKHISEIA 564
            ||||.|:.:.||:|||||||.:|.:||..|..|||||||||||:|||.||:| .|....|..:||
Worm  1034 VGFTTISGESTPMEVVTFLNKLYTLFDSIIRRYDVYKVETIGDAYMVVSGVPQYKTMEYHAEQIA 1098

  Fly   565 TMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEA 629
            .||:.:|.|...|.||....|.:.||.|:||||.|||:||..||||.||||||||||||||.|||
Worm  1099 MMAIHILSAVRSFSIPHRSCEPLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNGEA 1163

  Fly   630 QKIHI---TEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWLTCKDG 674
            .:||.   |:::..|:.|  ||..|.||.:.:||||.|:||||..:.|
Worm  1164 LRIHCSSSTQKVLTSIDQ--GFLLEERGSLAIKGKGQMTTYWLNGRAG 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	50/304 (16%)
		HNOBA	<439..479	CDD:285003	17/60 (28%)
		CYCc	459..647	CDD:214485	109/191 (57%)
		Guanylate_cyc	485..669	CDD:278633	107/187 (57%)
gcy-12	NP_494995.2	PBP1_Speract_GC_like	123..545	CDD:107365	3/6 (50%)
		ANF_receptor	140..519	CDD:279440
		PK_GC-A_B	648..957	CDD:270944	59/387 (15%)
		TyrKc	688..951	CDD:197581	50/308 (16%)
		HNOBA	<967..1012	CDD:285003	14/44 (32%)
		CYCc	991..1183	CDD:214485	109/193 (56%)
		Guanylate_cyc	1018..1206	CDD:278633	109/189 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910