DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and gcy-28

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001021600.1	Gene:	gcy-28 / 172051	WormBaseID:	WBGene00020131	Length:	1276	Species:	Caenorhabditis elegans

Alignment Length:	707	Identity:	202/707 - (28%)
Similarity:	313/707 - (44%)	Gaps:	150/707 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KSGENPDPSPCPAGGSRMPTPSVKIDISTCQSNRPMESRTAPDDVNPSGEGGLLLVPTHHNLQLD 72
            :..||.|.||......|:|....::...:.::.|...|    ::.:|.......|...:..|...
Worm   659 QKAENGDCSPINEVQFRLPLNDRRVSSPSSEATRKKNS----NEEDPENGAKKSLSLKNRKLSFG 719

  Fly    73 KISVRSISSEDISNGGSGRCCNAAARNPAIKTGRRLQLMQMIILPFIPILALIVQTSVTLQEILE 137
            .:|.:|         |||......|:|..                     .:..:|::
Worm   720 MVSFKS---------GSGGSVETIAQNNT---------------------QIYTKTAI------- 747

  Fly   138 YRSAVADIETQVTIATDLGKVVTRLQLERSEVAFYIFTNGSKQRANLTLRFANTDHALNNMTTWS 202
            ::..|..|: ::.|..   |...||.|.|:::.      ..|:..:|     ..||.  ...|.:
Worm   748 FKGVVVAIK-KLNIDP---KKYPRLDLSRAQLM------ELKKMKDL-----QHDHI--TRFTGA 795

  Fly   203 EISVPTAPDEDEDDREMMLNRYEFQSRLNEFRDRVRLEPEESSITEVMNWYTSINRGLLHHLSEQ 267
            .|..|         ...::..|..:..|.:.     ||.|:..:.::|.:      .|||.|.:.
Worm   796 CIDFP---------HYCVVTEYCPKGSLEDI-----LENEKIELDKLMKY------SLLHDLVKG 840

  Fly   268 IKETDNSGVWRYLVGFKNLLKSIECQNIA------TSFGI-RYYGRGSLTAENFVSYVRYEFM-- 323
            :....||.:..:     ..|||..|...:      |.||: |.:....:..|....:..|:.|
Worm   841 LFFLHNSEIRSH-----GRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLW 900

  Fly   324 -AREMINSTLNYAPMLKNMYTNITSTKK---------FHRAK-QMGTTLLKN---NPNVSNERSA 374
             |.|::..: |..||         .|:|         .|... :.|...|:|   :||
Worm   901 TAPELLRDS-NAPPM---------GTQKGDIYSFAIILHEMMFRKGVFALENEDLSPN------- 948

  Fly   375 IEYYELMNNYTDDLRILQKALRRLIKE--------YVDKTLVEA----------DRKEAIGIAIL 421
                |::......:...|:.||..:.|        .::.||:..          :|.|...:...
Worm   949 ----EIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKA 1009

  Fly   422 VVVLIVSPVIIVLVKNAAATIQLYALNL----SQKAKELKREKRKSDSLLFQMLPPSVAMQLKQT 482
            |..|........||.|....::.||.||    .::.:|...||:|.:.||.|:|||::|..|...
Worm  1010 VRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAG 1074

  Fly   483 QQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGDSYMV 547
            :.|.||.|:.||||||||||||.:::..||::|||.||.:|..||..::.:.|||||||||:|||
Worm  1075 RAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMV 1139

  Fly   548 ASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCL 612
            .||||.:. :.|.::||.|:|.||.....|.|.....|.:::|.|:|:|.||||:||:|||||||
Worm  1140 VSGLPERR-DDHANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCL 1203

  Fly   613 FGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYWL 669
            |||||||:|||||.|...|||::::.:|.|.|..||:.|.||.:::||||:.:||||
Worm  1204 FGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWL 1260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	49/259 (19%)
		HNOBA	<439..479	CDD:285003	15/43 (35%)
		CYCc	459..647	CDD:214485	99/187 (53%)
		Guanylate_cyc	485..669	CDD:278633	99/183 (54%)
gcy-28	NP_001021600.1	PBP1_NPR_like	42..486	CDD:107368
		ANF_receptor	64..465	CDD:279440
		PK_GC-A_B	722..1016	CDD:270944	70/393 (18%)
		STYKc	741..1008	CDD:214568	61/336 (18%)
		HNOBA	<1026..1071	CDD:285003	15/44 (34%)
		CYCc	1050..1233	CDD:214485	97/183 (53%)
		Guanylate_cyc	1077..1262	CDD:278633	101/185 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010