Protein Alignment CG33958 and Gucy2e

DIOPT Version :10

• Sequence 1: NP_001033958.1
• Gene: CG33958 / 37088
• FlyBaseID: FBgn0053958
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: XP_036012232.1
• Gene: Gucy2e / 14919
• MGIID: 105123
• Length: 1139
• Species: Mus musculus
• Alignment Length: 786
• Identity: 232/786 - (29%)
• Similarity: 341/786 - (43%)
• Gaps: 219/786 - (27%)

  Fly    51 DVNPSGEGGLLLVPTHHNLQLDKI--SVRSISSE-DISNGGSG-----RC-------CNAAARNP 100
            |.:.|||   .|..||   .||.:  |:||..:. ....||..     .|       ||.
Mouse   440 DTDASGE---QLFATH---LLDPVLGSLRSAGTPMHFPRGGPAPGPDPSCWFDPDVICNG----- 493

  Fly   101 AIKTGRRLQLMQMIILPFIPILALIVQTSVTLQEILEYRSAVADIETQVTIATDLGKVVTRLQLE 165
            .::.|       ::.:.|:.::.:.: |...|...|.:|.      ..:.:|:...|::..|:
Mouse   494 GVEPG-------LVFVGFLLVIGMGL-TGAFLAHYLRHRL------LHMQMASGPNKIILTLE-- 542

  Fly   166 RSEVAFYIFTNGSKQ------RANLTLRFANTDHALNNMTTWSEI-SVPTAPDED------EDDR 217
              :|.|.....||.:      |::|..|.|            |:| |||:.|.|.      |.|
Mouse   543 --DVTFLHPPGGSSRKVVQGSRSSLATRSA------------SDIRSVPSQPQESTNVGLYEGD- 592

  Fly   218 EMMLNRYEFQ-------------SRLNEFR-DRVRL--------------EPEESSITEVMNWYT 254
            .:.|.::..:             |:|.|.| :.|.|              .|.| .|..|::.:.
Mouse   593 WVWLKKFPGEHHMAIRPATKTAFSKLRELRHENVALYLGLFLAGTADSPATPGE-GILAVVSEHC 656

  Fly   255 SINRGLLHHLSEQIK-ETDNSGVWRY--------LVGFKNL---------LKSIECQNIATSFGI 301
            :  ||.||.|..|.: :.|    |.:        :.|.:.|         |||..|. :...|.:
Mouse   657 A--RGSLHDLLAQREIKLD----WMFKSSLLLDLIKGMRYLHHRGVAHGRLKSRNCV-VDGRFVL 714

  Fly   302 RY----YG---------------------------------RGSLTAENF-VSYVRYEFMAREMI 328
            :.    :|                                 ||:|..:.| ::.:..|.:.|...
Mouse   715 KVTDHGHGRLLEAQRVLPEPPSAEDQLWTAPELLRDPSLERRGTLAGDVFSLAIIMQEVVCRSTP 779

  Fly   329 NSTLNYAPMLKNMYTNITSTKKFHRAKQMGTTLLKNNPNVSNERSAIEYYELMNN---YTDDLRI 390
            .:.|...|  :.:...:.|.....|            |.||.:::.:|..:||..   ...:||.
Mouse   780 YAMLELTP--EEVIQRVRSPPPLCR------------PLVSMDQAPMECIQLMTQCWAEHPELRP 830

  Fly   391 LQKALRRLIKEYVDKTLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAAATIQLYALNLS----Q 451
            .......|.|.      :...||..|                  :.:....::.|:.||.    :
Mouse   831 SMDLTFDLFKS------INKGRKTNI------------------IDSMLRMLEQYSSNLEDLIRE 871

  Fly   452 KAKELKREKRKSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVV 516
            :.:||::||:|:|.||.||||||||..||....|..|.:|.||:|||||||||.|:|...|:|||
Mouse   872 RTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVV 936

  Fly   517 TFLNSIYRVFDERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPR 581
            ..||.:|.:||..|..:||||||||||:||||||||.:||.:|.:|||.|:||:|.|...||:..
Mouse   937 DLLNDLYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRH 1001

  Fly   582 AGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHI---TEEMHDSLQ 643
            ..:..|:||.|:|:||.|||:||..|||||||||||||||||||||...:||:   |..:..:|.
Mouse  1002 MPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALD 1066

  Fly   644 QVGGFRTEHRGLIDVKGKGLMSTYWLTCKDGPVRAREEISWRADIQPVFLDH----LKLHPPTDY 704
            |  ||:.|.||..::||||:..||||.   |.:...:.|....|:||...:|    .::.|....
Mouse  1067 Q--GFQMECRGRTELKGKGIEDTYWLV---GRLGFNKPIPKPPDLQPGASNHGISLQEIPPERRK 1126

  Fly   705 KLPKRK 710
            ||.|.:
Mouse  1127 KLEKAR 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:462453	63/336 (19%)
		CYCc	459..647	CDD:214485	111/190 (58%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594	12/30 (40%)
		PK_GC-2D	570..845	CDD:270945	57/315 (18%)
		HNOBA	<854..899	CDD:462234	19/44 (43%)
		CYCc	879..1070	CDD:214485	112/192 (58%)