DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and gc2

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_021333059.1	Gene:	gc2 / 140425	ZFINID:	ZDB-GENE-011128-8	Length:	1120	Species:	Danio rerio

Alignment Length:	380	Identity:	154/380 - (40%)
Similarity:	211/380 - (55%)	Gaps:	46/380 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 MLKNMYTNITSTKKFHRAKQMGTTLLKNNPNVSNERSAIEYYELMNNYTDDLRILQKALRRLIKE 401
            ||:|.:..|  .:|..:...|      ..|.||.:.:.:|..:||....::    |...|....|
Zfish   752 MLENTFDEI--VQKVRKPPPM------CRPIVSPDHAPMECIQLMKQCWNE----QPEKRPTFDE 804

  Fly   402 YVDK-TLVEADRKEAIGIAILVVVLIVSPVIIVLVKNAAATIQLYALNLS----QKAKELKREKR 461
            ..|: ..|...:|..|                  :.:....::.|:.||.    ::.:||:.||:
Zfish   805 IFDQFKNVNKGKKTNI------------------IDSMLRMLEQYSSNLEELIRERTEELEIEKQ 851

  Fly   462 KSDSLLFQMLPPSVAMQLKQTQQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVF 526
            |::.||.||||||||..||....|..|.:|:|::|||||||||.|:|:..|:|||..||.:|..|
Zfish   852 KTEKLLTQMLPPSVAEALKLGTTVEPEHFESVSLYFSDIVGFTTISANSEPIEVVDLLNDLYTTF 916

  Fly   527 DERIECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRC 591
            |..|..:||||||||||:||||||:||.|||:|.:|||.||||:|.|...||:....|..|:||.
Zfish   917 DAVIGNHDVYKVETIGDAYMVASGVPVPNGNRHAAEIANMALDILSAVGTFRMRHMPDVPVRIRI 981

  Fly   592 GVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVG-GFRTEHRGL 655
            |:||||.|||:||..|||||||||||.|||||||||...:||:.......|.::. |:|.|.|..
Zfish   982 GLHTGPCVAGVVGLTMPRYCLFGDTVTTASRMESTGLPYRIHVHSSTVKILMELKLGYRVELRAR 1046

  Fly   656 IDVKGKGLMSTYWLTCKDGPVRAREEISWRADIQPVFLDHLKLHPPTDYKLPKRK 710
            .::|||.:..|||||.:||..:.       ..:.||....|:   ..|:|:..:|
Zfish  1047 TELKGKRIEETYWLTGRDGFTKP-------LPVPPVLKSGLE---SKDFKVMLKK 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	13/58 (22%)
		HNOBA	<439..479	CDD:285003	18/43 (42%)
		CYCc	459..647	CDD:214485	110/188 (59%)
		Guanylate_cyc	485..669	CDD:278633	104/184 (57%)
gc2	XP_021333059.1	PBP1_sensory_GC_DEF_like	59..440	CDD:107366
		PK_GC-2D	551..815	CDD:270945	17/74 (23%)
		HNOBA	<824..869	CDD:311573	18/44 (41%)
		CYCc	848..1040	CDD:214485	111/191 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810