DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and gucy2f

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_571939.2	Gene:	gucy2f / 140424	ZFINID:	ZDB-GENE-011128-7	Length:	1107	Species:	Danio rerio

Alignment Length:	696	Identity:	191/696 - (27%)
Similarity:	306/696 - (43%)	Gaps:	172/696 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 IILPFIPILALIVQTSVTLQEILEYR-----------SAVADIETQVTIATDLGKVVTRLQLERS 167
            :|:.|: |:.:||..|:.|...:..|           ..:..:|....|...|.|....|: :.|
Zfish   474 VIIAFV-IVLIIVLGSIGLSLFIRRRIQQIQLIKGPNRILLTLEDLTFINPQLSKRKITLE-DLS 536

  Fly   168 EVAFYIFTNGSKQRANLTLRFANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSRLNE 232
            :...||....:..|:......|...|..:|:..:....|......:...:|:..:..:..:::.:
Zfish   537 DSKSYIEEKSTGDRSRSVNSMATATHETSNVAVYEGDWVWLKKFTEGHFKEVKQSTTKIFTKMKD 601

  Fly   233 FRDRVRLEPEESSITEVMNWYTS----------INRGLLHHLSEQIKETDNSGVWRY---LVGFK 284
            .|:        .::...:.::|.          .:||.||.|   ::..|....|.:   ||  .
Zfish   602 LRN--------ENVNPFLGFFTDCEMFAIVTEHCSRGSLHDL---LRNDDVKLDWMFKSSLV--L 653

  Fly   285 NLLKSIECQNIATSFGIRY-----YGRGSLTAENFVSYVRYEFMAREMINSTLNYAPMLKNMYTN 344
            :|:|           |::|     :..|.|.:.|.|...|:       :....:|.      |..
Zfish   654 DLIK-----------GMKYLHHREFPHGRLKSRNCVVDGRF-------VLKITDYG------YNE 694

  Fly   345 ITSTKKFHR--------------------AKQMGT---------TLLKN---------------- 364
            |..|:|..:                    :.:.||         .:|:.
Zfish   695 ILETQKAPKETLPPEDLFWTAPEHLRDPESPRKGTYKGDVYSFAIILQEVVVRGAPYCMLGLSPE 759

  Fly   365 -------------NPNVSNERSAIEYYELMNNYTDDLRILQKALRRLIKEYVDK-TLVEADRKEA 415
                         .|.|:.:::.:|..:||.....:    |...|....:..|: .|:...:|..
Zfish   760 EIIRKVKKPPPMCRPTVAPDQAPLECIQLMKQCWSE----QPDRRPPFDQIFDQFKLINKGKKTN 820

  Fly   416 IGIAILVVVLIVSPVIIVLVKNAAATIQLYALNLS----QKAKELKREKRKSDSLLFQMLPPSVA 476
            |                  :.:....::.|:.||.    ::.:||:.||::::.||.:|||||||
Zfish   821 I------------------IDSMLRMLEQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPPSVA 867

  Fly   477 MQLKQTQQVPAELYEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETI 541
            ..||....|..|.::.||||||||||||.|::...|:|||..||.:|.:||..:..:||||||||
Zfish   868 EALKTGASVEPEYFDQVTIYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLGSHDVYKVETI 932

  Fly   542 GDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTK 606
            ||:||||||||.||||||.:|||.|:|::|.:...|::....:..|:||.|:|:||.|||:||..
Zfish   933 GDAYMVASGLPKKNGNKHAAEIANMSLNILSSVGSFKMRHMPEVPVRIRIGIHSGPCVAGVVGLT 997

  Fly   607 MPRYCLFGDTVNTASRMESTGEAQKIHI---TEEMHDSLQQVGGFRTEHRGLIDVKGKGLMSTYW 668
            |||||||||||||||||||||...:||:   |.::..||..  |::.:.||..::||||:..|||
Zfish   998 MPRYCLFGDTVNTASRMESTGLPYRIHVNISTVQILRSLND--GYKIDVRGKTELKGKGIEETYW 1060

  Fly   669 LTCK-------DGPVRAREEISWR----ADIQPVFLDHLKLHPPTD 703
            |..|       ..|...:...:|:    .:|:.:|   .|.:.|.|
Zfish  1061 LVGKANFTKPLPNPPEIKPGDNWQDMMTEEIKSLF---RKANRPVD 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	44/312 (14%)
		HNOBA	<439..479	CDD:285003	16/43 (37%)
		CYCc	459..647	CDD:214485	106/190 (56%)
		Guanylate_cyc	485..669	CDD:278633	102/186 (55%)
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF_like	59..440	CDD:107366
		PK_GC-2D	551..816	CDD:270945	42/305 (14%)
		HNOBA	<825..870	CDD:311573	16/44 (36%)
		CYCc	850..1042	CDD:214485	107/193 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810