DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33958 and Adcy8

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_033753.2	Gene:	Adcy8 / 11514	MGIID:	1341110	Length:	1249	Species:	Mus musculus

Alignment Length:	830	Identity:	178/830 - (21%)
Similarity:	308/830 - (37%)	Gaps:	245/830 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CPAGGSRMPTP-------SVKIDISTCQSNRPMESRTAPD-DVNPSGEGGLLL------------ 62
            |.:|   :|.|       .|::.:|..::.|.:.|||..| |:......|.:|
Mouse   465 CVSG---LPEPRRDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFD 526

  Fly    63 -----VPTHHNLQLDKISVR---SISSEDISNG------GSGRCCNAAARNPAIKTGRRLQLMQM 113
                 |...:.|:...|..|   |.::.|..||      |.|:..|...|...|:|       .:
Mouse   527 VWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIET-------YL 584

  Fly   114 IILPFIPILAL---IVQTSVTLQEILEYRSAVADIETQVTIATDLGKVVTRLQLERSEVAFYIFT 175
            |..|...:|.|   ||:.||:..:                              .|:..|  .||
Mouse   585 IKQPEESLLCLPEDIVKESVSCSD------------------------------RRNSGA--TFT 617

  Fly   176 NGSKQRANLTLRFANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSRLN---EFRDRV 237
            .||   .:..|.|.|.....|.:...:..|:...|:.......:.....|...|:.   :.|...
Mouse   618 EGS---WSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGD 679

  Fly   238 RLEPEESSITEVMNWYTSINRGLLHHLSEQIKETDNSG------VWRYLVGFKNLLKSIECQNIA 296
            :|..|......:|...:|:.    |..|:...|...|.      |..::...::||.|.....:.
Mouse   680 KLRREHIKPFSLMFKDSSLE----HKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMT 740

  Fly   297 TSFGIRYYGRGSL----TAENF----------VSYVRYEFMAREMINSTLNYAPMLKNMYTNITS 347
            ..|.|......:|    |||::          ..::...::||.:|    .:|.:|.|.
Mouse   741 IQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVI----IFASILINF------ 795

  Fly   348 TKKFHRAKQMGTTLL-------KNNP--NVSNERSAI--------EYYELMNNYTDDLRILQKAL 395
                     :|..|.       |:.|  |::...||:        ||:.    :|..|.::..|:
Mouse   796 ---------LGAVLNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFV----FTGVLAMVTCAV 847

  Fly   396 -RRLIKEYVDKTLVEADRKEAIGIAILVVVLIVSPVIIVLV---------------------KNA 438
             .||              ...:.:|:|::::.:..::...:                     |.|
Mouse   848 FLRL--------------NSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDFLGTKEA 898

  Fly   439 AATIQ----------------------LYALNLSQKAKELKREKRKSDSLLFQMLPPSVAMQL-- 479
            :..:.                      |:.:...::..|:|..:..::::|..:||..||...
Mouse   899 SLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLE 963

  Fly   480 --KQTQQVPAELYEAVTIYFSDIVGFTEIAADC----TPLEVVTFLNSIYRVFDERI---ECYDV 535
              :..:::.::.|:||.:.|:.|.||.:..:..    ..:|.:..||.|...|||.:   ...|:
Mouse   964 KDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDI 1028

  Fly   536 YKVETIGDSYMVASGL-PVKNGNK----HISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHT 595
            .|::|||.:||..||| |.|...:    |:..:|..:|.|.:  |:..|.:......::|.|:..
Mouse  1029 EKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTE--SIQEINKHSFNNFELRIGISH 1091

  Fly   596 GPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKG 660
            |.||||::|.|.|:|.::|.|||.||||:|||.:.:|.:.||.:..|:. .||..::||.|.|||
Mouse  1092 GSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKD-QGFAFDYRGEIYVKG 1155

  Fly   661 ----KGLMSTYWLTCKDGPVRAREEISWRADIQPVFLDHLKLHPPTDYKL 706
                :|.:.||:|..:..|             .|..|...:|  |..|.|
Mouse  1156 ISEQEGKIKTYFLLGRVQP-------------NPFILPPRRL--PGQYSL 1190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	51/277 (18%)
		HNOBA	<439..479	CDD:285003	8/61 (13%)
		CYCc	459..647	CDD:214485	63/203 (31%)
		Guanylate_cyc	485..669	CDD:278633	69/199 (35%)
Adcy8	NP_033753.2	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..180
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..33
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..118
		AC_N	<159..398	CDD:292831
		CYCc	364..562	CDD:214485	22/99 (22%)
		Guanylate_cyc	403..587	CDD:278633	29/131 (22%)
		DUF1053	615..709	CDD:283888	19/100 (19%)
		CYCc	942..1146	CDD:214485	65/206 (32%)
		Guanylate_cyc	971..1170	CDD:278633	70/201 (35%)
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1107..1249		34/100 (34%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1198..1213
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810