DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33958 and ADCY8

DIOPT Version :9

Sequence 1:NP_001033958.1 Gene:CG33958 / 37088 FlyBaseID:FBgn0053958 Length:710 Species:Drosophila melanogaster
Sequence 2:NP_001106.1 Gene:ADCY8 / 114 HGNCID:239 Length:1251 Species:Homo sapiens


Alignment Length:802 Identity:181/802 - (22%)
Similarity:310/802 - (38%) Gaps:189/802 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 CPAGGSRMPTP-------SVKIDISTCQSNRPMESRTAPD-DVNPSGEGGLLL------------ 62
            |.:|   :|.|       .|::.:|..::.|.:.|||..| |:......|.:|            
Human   467 CVSG---LPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFD 528

  Fly    63 -----VPTHHNLQLDKISVR---SISSEDISNG------GSGRCCNAAARNPAIKTGRRLQLMQM 113
                 |...:.|:...|..|   |.::.|..||      |.|:..|...|...|:|         
Human   529 VWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIET--------- 584

  Fly   114 IILPFIPILALIVQTSVTLQEILEYRSAVADIETQVTIATDLGKVVTRLQLERSEVAFYIFTNGS 178
                     .||.|...:|..:.|      ||..:...::|          .|:..|  .||.||
Human   585 ---------YLIKQPEDSLLSLPE------DIVKESVSSSD----------RRNSGA--TFTEGS 622

  Fly   179 KQRANLTLRFANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSRLN---EFRDRVRLE 240
               .:..|.|.|.....|.:...:..|:...|:.......:.....|...|:.   :.|...:|.
Human   623 ---WSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLR 684

  Fly   241 PEESSITEVMNWYTSINRGLLHHLSEQIKETDNSG------VWRYLVGFKNLLKSIECQNIATSF 299
            .|......:|...:|:.    |..|:...|...|.      |..::...::||.|.....:...|
Human   685 REHIKPFSLMFKDSSLE----HKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQF 745

  Fly   300 GIRYYGRGSL----TAENF----------VSYVRYEFMAREMINSTLNYAPMLKNMYTNITSTKK 350
            .|......:|    |||::          ..::...::||.:|    .:|.:|.|....|.:.  
Human   746 SILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVI----IFASILINFLGAILNI-- 804

  Fly   351 FHRAKQMGTTLLKNNP--NVSNERSAI--------EYYE-------------LMNNYTDDLRIL- 391
                  :.....|:.|  |::...||:        ||:.             |..|....|.:| 
Human   805 ------LWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLL 863

  Fly   392 -QKALRRLIKEYVDKTL------VEADRKEAIGIAILVVVLIVSPVIIVL-----VKNAAATIQL 444
             ..|:..|:.|.|...|      :....::.:|...:.::|:...::.|.     ::..|....|
Human   864 IMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFL 928

  Fly   445 YALNLSQKAKELKREKRKSDSLLFQMLPPSVAMQL----KQTQQVPAELYEAVTIYFSDIVGFTE 505
            :.:...::..|:|..:..::::|..:||..||...    :..:::.::.|:||.:.|:.|.||.:
Human   929 WRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFAD 993

  Fly   506 IAADC----TPLEVVTFLNSIYRVFDERI---ECYDVYKVETIGDSYMVASGL-PVKNGNK---- 558
            ..:..    ..:|.:..||.|...|||.:   ...|:.|::|||.:||..||| |.|...:    
Human   994 FYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWG 1058

  Fly   559 HISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRM 623
            |:..:|..:|.|.:  |:..|.:......::|.|:..|.||||::|.|.|:|.::|.|||.||||
Human  1059 HLCALADFSLALTE--SIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRM 1121

  Fly   624 ESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKG----KGLMSTYWLTCKDGPVRAREEISW 684
            :|||.:.:|.:.||.:..|:. .||..::||.|.|||    :|.:.||:|..:..|         
Human  1122 DSTGVSGRIQVPEETYLILKD-QGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQP--------- 1176

  Fly   685 RADIQPVFLDHLKLHPPTDYKL 706
                .|..|...:|  |..|.|
Human  1177 ----NPFILPPRRL--PGQYSL 1192

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33958NP_001033958.1 NIT 159..396 CDD:285564 52/284 (18%)
HNOBA <439..479 CDD:285003 9/39 (23%)
CYCc 459..647 CDD:214485 63/203 (31%)
Guanylate_cyc 485..669 CDD:278633 69/199 (35%)
ADCY8NP_001106.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..182
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..109
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..92
AC_N <161..400 CDD:292831
CYCc 366..564 CDD:214485 22/99 (22%)
Guanylate_cyc 405..589 CDD:278633 30/142 (21%)
DUF1053 617..711 CDD:283888 19/100 (19%)
CYCc 944..1148 CDD:214485 65/206 (32%)
Guanylate_cyc 973..1172 CDD:278633 70/201 (35%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1109..1251 34/100 (34%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1200..1215
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1251
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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