DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33958 and ADCY8

DIOPT Version :10

Sequence 1:NP_001033958.1 Gene:CG33958 / 37088 FlyBaseID:FBgn0053958 Length:710 Species:Drosophila melanogaster
Sequence 2:NP_001106.1 Gene:ADCY8 / 114 HGNCID:239 Length:1251 Species:Homo sapiens


Alignment Length:802 Identity:181/802 - (22%)
Similarity:310/802 - (38%) Gaps:189/802 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 CPAGGSRMPTP-------SVKIDISTCQSNRPMESRTAPD-DVNPSGEGGLLL------------ 62
            |.:|   :|.|       .|::.:|..::.|.:.|||..| |:......|.:|            
Human   467 CVSG---LPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFD 528

  Fly    63 -----VPTHHNLQLDKISVR---SISSEDISNG------GSGRCCNAAARNPAIKTGRRLQLMQM 113
                 |...:.|:...|..|   |.::.|..||      |.|:..|...|...|:|         
Human   529 VWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIET--------- 584

  Fly   114 IILPFIPILALIVQTSVTLQEILEYRSAVADIETQVTIATDLGKVVTRLQLERSEVAFYIFTNGS 178
                     .||.|...:|..:.|      ||..:...::|          .|:..|  .||.||
Human   585 ---------YLIKQPEDSLLSLPE------DIVKESVSSSD----------RRNSGA--TFTEGS 622

  Fly   179 KQRANLTLRFANTDHALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSRLN---EFRDRVRLE 240
               .:..|.|.|.....|.:...:..|:...|:.......:.....|...|:.   :.|...:|.
Human   623 ---WSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLR 684

  Fly   241 PEESSITEVMNWYTSINRGLLHHLSEQIKETDNSG------VWRYLVGFKNLLKSIECQNIATSF 299
            .|......:|...:|:.    |..|:...|...|.      |..::...::||.|.....:...|
Human   685 REHIKPFSLMFKDSSLE----HKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQF 745

  Fly   300 GIRYYGRGSL----TAENF----------VSYVRYEFMAREMINSTLNYAPMLKNMYTNITSTKK 350
            .|......:|    |||::          ..::...::||.:|    .:|.:|.|....|.:.  
Human   746 SILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVI----IFASILINFLGAILNI-- 804

  Fly   351 FHRAKQMGTTLLKNNP--NVSNERSAI--------EYYE-------------LMNNYTDDLRIL- 391
                  :.....|:.|  |::...||:        ||:.             |..|....|.:| 
Human   805 ------LWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLL 863

  Fly   392 -QKALRRLIKEYVDKTL------VEADRKEAIGIAILVVVLIVSPVIIVL-----VKNAAATIQL 444
             ..|:..|:.|.|...|      :....::.:|...:.::|:...::.|.     ::..|....|
Human   864 IMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFL 928

  Fly   445 YALNLSQKAKELKREKRKSDSLLFQMLPPSVAMQL----KQTQQVPAELYEAVTIYFSDIVGFTE 505
            :.:...::..|:|..:..::::|..:||..||...    :..:::.::.|:||.:.|:.|.||.:
Human   929 WRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFAD 993

  Fly   506 IAADC----TPLEVVTFLNSIYRVFDERI---ECYDVYKVETIGDSYMVASGL-PVKNGNK---- 558
            ..:..    ..:|.:..||.|...|||.:   ...|:.|::|||.:||..||| |.|...:    
Human   994 FYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWG 1058

  Fly   559 HISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMPRYCLFGDTVNTASRM 623
            |:..:|..:|.|.:  |:..|.:......::|.|:..|.||||::|.|.|:|.::|.|||.||||
Human  1059 HLCALADFSLALTE--SIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRM 1121

  Fly   624 ESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKG----KGLMSTYWLTCKDGPVRAREEISW 684
            :|||.:.:|.:.||.:..|:. .||..::||.|.|||    :|.:.||:|..:..|         
Human  1122 DSTGVSGRIQVPEETYLILKD-QGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQP--------- 1176

  Fly   685 RADIQPVFLDHLKLHPPTDYKL 706
                .|..|...:|  |..|.|
Human  1177 ----NPFILPPRRL--PGQYSL 1192

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33958NP_001033958.1 NIT 159..396 CDD:462453 52/284 (18%)
CYCc 459..647 CDD:214485 63/203 (31%)
ADCY8NP_001106.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..182
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..109
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..92
AcyC 214..567 CDD:441717 22/102 (22%)
Guanylate_cyc 405..589 CDD:425528 30/142 (21%)
Adcy_cons_dom 617..712 CDD:461877 20/101 (20%)
Guanylate_cyc 973..1172 CDD:425528 70/201 (35%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1109..1251 34/100 (34%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1200..1215
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1251
Blue background indicates that the domain is not in the aligned region.

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