DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and ADCY3

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_011530791.1	Gene:	ADCY3 / 109	HGNCID:	234	Length:	1186	Species:	Homo sapiens

Alignment Length:	267	Identity:	81/267 - (30%)
Similarity:	141/267 - (52%)	Gaps:	31/267 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 VKNAAATIQLYALNLSQKAKELKREKRKSDSLLFQMLPPSVAMQL----KQTQQVPAELYEAVTI 495
            |:..|.|:.|:.:.:..:.:.:...:|.:::|:..|||..||...    |:.:::.::.|:.:.:
Human   902 VEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGV 966

  Fly   496 YFSDIVGF----TEIAADCTPLEVVTFLNSIYRVFDERIE---CYDVYKVETIGDSYMVASGL-P 552
            .|:.:..|    ||.:.:...:|.:.|||.|...||..::   ...:.|::|||.:||.|||: |
Human   967 MFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTP 1031

  Fly   553 VKNGN----------------KHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAG 601
            ..|.|                :|::::|..||.:.|  ::..|.........:|.|::.|.|:||
Human  1032 DVNTNGFASSNKEDKSERERWQHLADLADFALAMKD--TLTNINNQSFNNFMLRIGMNKGGVLAG 1094

  Fly   602 IVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKGKGLMST 666
            ::|.:.|.|.::|:|||.||||||||....|.:.||....|::. |||...||.|.|||||.:.|
Human  1095 VIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY-GFRFVRRGPIFVKGKGELLT 1158

  Fly   667 YWLTCKD 673
            ::|..:|
Human  1159 FFLKGRD 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564
		HNOBA	<439..479	CDD:285003	10/39 (26%)
		CYCc	459..647	CDD:214485	63/215 (29%)
		Guanylate_cyc	485..669	CDD:278633	67/207 (32%)
ADCY3	XP_011530791.1	AC_N	<44..303	CDD:292831
		CYCc	273..490	CDD:214485
		Guanylate_cyc	310..516	CDD:278633
		CYCc	925..1143	CDD:214485	66/220 (30%)
		Guanylate_cyc	956..1163	CDD:278633	68/209 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810