DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and ADCY2

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens

Alignment Length:	338	Identity:	87/338 - (25%)
Similarity:	159/338 - (47%)	Gaps:	63/338 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   402 YVDKTLVEADRKEAIGIAIL-----VVVL-----------------IVSPVIIVLVKNAAATIQL 444
            :|..|::..:.::||..::|     .:||                 |::.|||.:..|.|.....
Human   145 FVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHK 209

  Fly   445 YALNLS------------QKAKELKREKRKSDSLLFQMLPPSVAMQLK----QTQQVP------- 486
            :.:.|:            :...:|:.|||:.:.||..:||..:||::|    |..|.|
Human   210 HLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMEN 274

  Fly   487 --------AELYEAVTIYFSDIVGFTEIAADCTPLEVVTFLNSIYRVFDERIECYDVYKVETIGD 543
                    .:.:..|:|.::||||||.:|:||:|.|:|..||.::..||:..:..:..:::.:||
Human   275 TNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGD 339

  Fly   544 SYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGDEFVQIRCGVHTGPVVAGIVGTKMP 608
            .|...||||:...| |......|.||:.:|....|.....|  :.:|.|||:|.|:.|::|.:..
Human   340 CYYCVSGLPISLPN-HAKNCVKMGLDMCEAIKKVRDATGVD--INMRVGVHSGNVLCGVIGLQKW 401

  Fly   609 RYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDVKG----KGLMSTYWL 669
            :|.::...|..|:.||:.|...::||:....:.|.  |.::.| .|..|::.    :.|:.||::
Human   402 QYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLN--GAYKVE-EGDGDIRDPYLKQHLVKTYFV 463

  Fly   670 TCKDGPVRAREEI 682
            ....|..|:.:.:
Human   464 INPKGERRSPQHL 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564
		HNOBA	<439..479	CDD:285003	12/51 (24%)
		CYCc	459..647	CDD:214485	63/206 (31%)
		Guanylate_cyc	485..669	CDD:278633	58/202 (29%)
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831	25/114 (22%)
		CYCc	236..439	CDD:214485	64/207 (31%)
		Guanylate_cyc	281..465	CDD:278633	57/189 (30%)
		DUF1053	495..599	CDD:283888
		CYCc	848..1056	CDD:214485
		Guanylate_cyc	878..1077	CDD:278633
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810