DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and ADCY1

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_066939.1	Gene:	ADCY1 / 107	HGNCID:	232	Length:	1119	Species:	Homo sapiens

Alignment Length:	337	Identity:	98/337 - (29%)
Similarity:	160/337 - (47%)	Gaps:	70/337 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   429 PVIIVLVKNAAATIQ------------LYALNLSQKAKELKREKRKSDSLLFQMLPPSVA----M 477
            |::.:|:.:.|..:.            |:|....::.:::::.|..:..:||.:||..||    |
Human   787 PIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLM 851

  Fly   478 QLKQTQQVPAELYEAVTIYFSDIVGFT----EIAADCTPLEVVTFLNSIYRVFDERIE---CYDV 535
            ...:...:..:.|..|.:.|:.|..|.    |:..:...:|.:..||.|...|||.:|   ..|:
Human   852 SNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDI 916

  Fly   536 YKVETIGDSYMVASGLPVKNGNK-------HISEIATMALDLLDASSVFRIPRAGDEFVQIRCGV 593
            .|::|||.:||.|.||...:|.|       |:|.:|..|:::.|....... ::.::|| :|.|:
Human   917 EKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINY-QSYNDFV-LRVGI 979

  Fly   594 HTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLIDV 658
            :.||||||::|.:.|:|.::|:|||.||||:|||...:|.:|||:|..|::. .:....||.:.|
Human   980 NVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRC-PYHFVCRGKVSV 1043

  Fly   659 KGKGLMSTYWL-------------------TCKDG---------PVRAREEISWRADIQPVFLDH 695
            ||||.|.||:|                   .|..|         ||.....:|.||.:.|
Human  1044 KGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRAGLQGRRPPVCPMPGVSVRAGLPP----- 1103

  Fly   696 LKLHPPTDYKLP 707
               |.|..| ||
Human  1104 ---HSPGQY-LP 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564
		HNOBA	<439..479	CDD:285003	11/55 (20%)
		CYCc	459..647	CDD:214485	69/205 (34%)
		Guanylate_cyc	485..669	CDD:278633	71/197 (36%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		AC_N	<161..292	CDD:292831
		CYCc	258..453	CDD:214485
		Guanylate_cyc	294..476	CDD:278633
		Interaction with calmodulin. /evidence=ECO:0000250	493..520
		CYCc	826..1037	CDD:214485	69/213 (32%)
		Guanylate_cyc	859..1056	CDD:278633	72/199 (36%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810