DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33958 and Adcy3

DIOPT Version :9

Sequence 1:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_612178.2	Gene:	Adcy3 / 104111	MGIID:	99675	Length:	1145	Species:	Mus musculus

Alignment Length:	734	Identity:	153/734 - (20%)
Similarity:	281/734 - (38%)	Gaps:	206/734 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 VQTSVTLQEILEYRSAVADI-ETQVTIAT--DLGKVVTRLQLERSEV-----------------A 170
            |.|...|..:|..:....|: .|.||:|.  :.|.:..|:.:.:|.:                 .
Mouse   415 VHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRC 479

  Fly   171 FYIFTNG--------SKQRANLTLRFANTDHALNNMTTWSEISVPTAP----------------- 210
            .|:...|        ||.....|.:......|:.|....|  |.|::|
Mouse   480 DYLDEKGIETYLIIASKPEVKKTAQNGLNGSAVPNGAPAS--SKPSSPALIETKEPNGSAHASGS 542

  Fly   211 -DEDEDDREMMLNRYEFQS-----RLNEFRDR-VRLEPEESSITEVMNWYTSINRGLLHHLSEQI 268
             .|:.:::|...:...|.:     ||.:..|| |....:|..:.::      :|..||...|.|:
Mouse   543 TSEEAEEQEAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQL------LNEALLERESAQV 601

  Fly   269 KETDNSGVWRYLVGFKNLLKSIECQNIATSFGIRYYGRGS-----------LTA----------- 311
            .:..|:    :|:..:.:...:|     |.:.:....:..           .||
Mouse   602 VKKRNT----FLLTMRFMDPEME-----TRYSVEKEKQSGAAFSCSCVVLFCTAMVEILIDPWLM 657

  Fly   312 ENFVSYVRYEFMAREMINSTLNYAPMLKNMYTN--------ITSTKKFHRAKQMGTTLLKNNPNV 368
            .|:|::|..|.:.  :|.:..:.|.:....:..        |..|:.......|....:....||
Mouse   658 TNYVTFVVGEVLL--LILTICSMAAIFPRSFPKKLVAFSSWIDRTRWARNTWAMLAIFILVMANV 720

  Fly   369 SNERSAIEYY----------EL---------MNNYTDDLRILQKALRRLIKEYVDKTLV------ 408
            .:..|.::||          ||         ..||...|.::...:...:...|..||:
Mouse   721 VDMLSCLQYYMGPYNMTAGMELDGGCMENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGA 785

  Fly   409 --------------EAD-----RKEAIGIAILVVVLIVSP----------------------VII 432
                          |.|     .|::..:|:..:.::.:|                      .::
Mouse   786 VTALNLYAWCPVFDEYDHKRFQEKDSPMVALEKMQVLATPGLNGTDSRLPLVPSKYSMTVMMFVM 850

  Fly   433 VL--------VKNAAATIQLYALNLSQKAKELKREKRKSDSLLFQMLPPSVAMQL----KQTQQV 485
            :|        |:..|.|:.|:.:.:..:.:.:...:|.:::|:..|||..||...    |:.:::
Mouse   851 MLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEEL 915

  Fly   486 PAELYEAVTIYFSDIVGF----TEIAADCTPLEVVTFLNSIYRVFDERIE---CYDVYKVETIGD 543
            .::.|:.:.:.|:.:..|    ||.:.:...:|.:.|||.|...||..::   ...:.|::|||.
Mouse   916 YSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGS 980

  Fly   544 SYMVASGL-PVKNGN----------------KHISEIATMALDLLDASSVFRIPRAGDEFVQIRC 591
            :||.|||: |..|.|                :|::::|..||.:.|  ::..|.........:|.
Mouse   981 TYMAASGVTPDVNTNGFTSSSKEEKSDKERWQHLADLADFALAMKD--TLTNINNQSFNNFMLRI 1043

  Fly   592 GVHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEAQKIHITEEMHDSLQQVGGFRTEHRGLI 656
            |::.|.|:||::|.:.|.|.::|:|||.||||||||....|.:.||....|::. |||...||.|
Mouse  1044 GMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY-GFRFVRRGPI 1107

  Fly   657 DVKGKGLMSTYWLTCKDGP 675
            .|||||.:.|::|..:|.|
Mouse  1108 FVKGKGELLTFFLKGRDRP 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	52/334 (16%)
		HNOBA	<439..479	CDD:285003	10/39 (26%)
		CYCc	459..647	CDD:214485	63/215 (29%)
		Guanylate_cyc	485..669	CDD:278633	67/207 (32%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454
		Guanylate_cyc	310..494	CDD:306677	14/78 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..564		9/61 (15%)
		Guanylate_cyc	915..1122	CDD:306677	68/209 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810