DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5721 and armc6

DIOPT Version :9

Sequence 1:	NP_611306.1	Gene:	CG5721 / 37084	FlyBaseID:	FBgn0034315	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	XP_009297218.1	Gene:	armc6 / 555425	ZFINID:	ZDB-GENE-100616-1	Length:	469	Species:	Danio rerio

Alignment Length:	474	Identity:	157/474 - (33%)
Similarity:	254/474 - (53%)	Gaps:	28/474 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAK-VISQDTFDDVVKENVVEFSMTPSEAKEETIKQFEAQGINLANIIKDL-----SVNPQTGQP 59
            ||| .|:|||||.||:||:.:|.|..|||.:|.|:|||:||::|:||:|.:     ..|.|....
Zfish     1 MAKRRITQDTFDSVVRENIDDFDMEESEALKEAIEQFESQGVDLSNIVKAVPKVSSEENAQDQTH 65

  Fly    60 VINETVDKIKEHIGQKLEETTELLEQLATLDAECKKSLAHRVLAGKNGAHDALITLLEETLSAES 124
            .:.:.::.:|..:.   ..:|.:|:.|.....:|....|.|.||.:..|:..:::..:::    :
Zfish    66 EVLQALESLKSAVS---SSSTSVLDDLRLFTDQCNLGFAQRYLAAQKDAYPTILSCCQKS----A 123

  Fly   125 PNESVLKKSLEAINSLTHKQPDLFDAEAMAVVLKLLALKVESEE--VTLLTLQWLQKACIMHEMN 187
            .::..|..:|.|:.:||..||||.|.|....::::|......::  |..|.::.::..|:.||.|
Zfish   124 GDKEALSVALAALCALTDGQPDLLDEEGKLFLIRVLTEHQHQQDAGVVCLCVRTVRNCCLKHENN 188

  Fly   188 RQNIMNTSALKLMKPLLGKGKDR------LVRELTAVFRFLVLDDDIRVEFGCAHEHARQIAGEV 246
            ||:::....|    |||.....|      :||:.....|.:..|||:||.||.|||||:.|..|.
Zfish   189 RQDLVKAGVL----PLLAGSITRYLQHPEVVRDACVALRVMTFDDDVRVPFGHAHEHAKMIVLEQ 249

  Fly   247 --LITLVELLPAY-QDPNVLADLLLTIGTLAVRQELCTAIDEAGGLKSVFEIMSSNLDEVRLNRE 308
              |..:||...|: ::.:||::|..|:..||||.|.|..|.:.||||.:..:::.:||...|.::
Zfish   250 NGLKVMVEAAKAHPENTSVLSELCATLSRLAVRNEFCQDIVDLGGLKFMITLLADSLDCQELVKQ 314

  Fly   309 ALKLLRALAGQDSVKSHIVQQGVAPIIKQLLETHQSNENIVAAALACVTTLTLRVQEHSAAFFDT 373
            .|..|:|:||.|.||..||..|.|.:|...:..|.:|..:.....|.:..|.||...:.....::
Zfish   315 VLSALKAIAGNDDVKDAIVNAGGAELIVMAMNRHMANAQVCEQGCAALCVLALRKPNNCKVIMES 379

  Fly   374 GIAEVIVEALRAHPKHKIVQRNGAWAIRNMVSRSRNQCETWISFGVEDLLNMAMKEHPSVEQDIK 438
            |.|...::|::.||....:|:.....:||:|:|||:..:..:..|.|.|::.|:..|.......:
Zfish   380 GGALAALQAMKTHPAEANMQKQSCMLLRNLVARSRDFTQPILEMGAEALISQALAAHRDCGDVGR 444

  Fly   439 AALRDLGCSVHLREEWTGT 457
            ||||||||.|.|||.||||
Zfish   445 AALRDLGCQVELRELWTGT 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5721	NP_611306.1	ARM	282..405	CDD:237987	35/122 (29%)
		armadillo repeat	282..316	CDD:293788	10/33 (30%)
		armadillo repeat	323..361	CDD:293788	10/37 (27%)
		armadillo repeat	367..403	CDD:293788	7/35 (20%)
armc6	XP_009297218.1	ARM	155..280	CDD:237987	39/128 (30%)
		armadillo repeat	189..227	CDD:293788	10/41 (24%)
		armadillo repeat	243..279	CDD:293788	10/35 (29%)
		ARM	265..342	CDD:237987	30/76 (39%)
		armadillo repeat	287..323	CDD:293788	11/35 (31%)
		armadillo repeat	329..365	CDD:293788	9/35 (26%)
		ARM	330..>425	CDD:237987	23/94 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590168
Domainoid	1	1.000	254	1.000	Domainoid score	I2016
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14121
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3163
OMA	1	1.010	-	-		QHG58269
OrthoDB	1	1.010	-	-		D273391at33208
OrthoFinder	1	1.000	-	-		FOG0007267
OrthoInspector	1	1.000	-	-		oto39993
orthoMCL	1	0.900	-	-		OOG6_105878
Panther	1	1.100	-	-	LDO	PTHR22895
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6154
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910