DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5721 and armc6

DIOPT Version :9

Sequence 1:	NP_611306.1	Gene:	CG5721 / 37084	FlyBaseID:	FBgn0034315	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	XP_012815487.1	Gene:	armc6 / 448573	XenbaseID:	XB-GENE-953885	Length:	469	Species:	Xenopus tropicalis

Alignment Length:	464	Identity:	160/464 - (34%)
Similarity:	246/464 - (53%)	Gaps:	17/464 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KVISQDTFDDVVKENVVEFSMTPSEAKEETIKQFEAQGINLANIIKDL----SVNPQTGQPVINE 63
            |.::|:|||.:|:||:.||.|.|.||..|.|:|||:||::|.||:|.:    ..|.......|.:
Frog     6 KWVTQETFDAIVQENMTEFEMDPEEALNEAIQQFESQGVDLTNIVKAVKKPCDENEVASNHDILQ 70

  Fly    64 TVDKIKEHIGQKLEETTELLEQLATLDAECKKSLAHRVLAGKNGAHDALITLLEETLSAESPNES 128
            |::.:::.:  :....:|:.|.|.....:||:.||||.|||:..|:..::    ||......:..
Frog    71 TLESLRKSV--QSSSVSEISELLIKFGDQCKQGLAHRYLAGQKSAYSVIL----ETWRLSEDDRE 129

  Fly   129 VLKKSLEAINSLTHKQPDLFDAEAMAVVLKLLALKVESEEVTLLTLQWLQKACIMHEMNRQNIMN 193
            .|..:|.|:::||..||||.:|....::|:.........||.||..:..:..|:.||.|||:::.
Frog   130 ALLNALYAMSALTEGQPDLLEASGQQLLLQTFKNHAGDAEVILLGTRLTRHVCLKHEQNRQDLVK 194

  Fly   194 TSALKLMKPLL---GKGKDRLVRELTAVFRFLVLDDDIRVEFGCAHEHARQIAGE--VLITLVEL 253
            ...|.|:...:   |...| :|||..:..|.:..||||||.||.||:||:.|..|  .|..|:|.
Frog   195 AGILPLLTGAIKTHGSDAD-VVREACSALRIMTFDDDIRVPFGHAHDHAKMIVLENGGLKCLIEA 258

  Fly   254 LPAYQD-PNVLADLLLTIGTLAVRQELCTAIDEAGGLKSVFEIMSSNLDEVRLNREALKLLRALA 317
            ..|:.| |.||::|..|:..|.||.|.|..:.:.|||..:..:::..:|...|.::.|..:||:|
Frog   259 AKAFTDNPGVLSELCGTVSRLCVRNEFCQDVVDLGGLNFMLALLADCIDHQELVKQVLSAIRAIA 323

  Fly   318 GQDSVKSHIVQQGVAPIIKQLLETHQSNENIVAAALACVTTLTLRVQEHSAAFFDTGIAEVIVEA 382
            |.|.||..||..|...:|...:..|..:..|.....|.:..|.||..|:.....:.|.|...::|
Frog   324 GNDDVKDAIVNSGGTDLIVLAMSRHLCSSQICDQGCAALAMLALRKPENCKVIMEGGGALAALQA 388

  Fly   383 LRAHPKHKIVQRNGAWAIRNMVSRSRNQCETWISFGVEDLLNMAMKEHPSVEQDIKAALRDLGCS 447
            ::|||:...||:.....|||:|||:|:..:..:..|.|.|:..|...|...:...|||||||||.
Frog   389 MKAHPQDTSVQKQACMVIRNLVSRTRDFSQPILEMGAESLILQARSAHKDCDDVAKAALRDLGCK 453

  Fly   448 VHLREEWTG 456
            |.|:|.|||
Frog   454 VELKELWTG 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5721	NP_611306.1	ARM	282..405	CDD:237987	35/122 (29%)
		armadillo repeat	282..316	CDD:293788	7/33 (21%)
		armadillo repeat	323..361	CDD:293788	9/37 (24%)
		armadillo repeat	367..403	CDD:293788	10/35 (29%)
armc6	XP_012815487.1	ARM	185..227	CDD:214547	13/42 (31%)
		armadillo repeat	189..227	CDD:293788	10/38 (26%)
		armadillo repeat	243..279	CDD:293788	12/35 (34%)
		armadillo repeat	288..322	CDD:293788	7/33 (21%)
		armadillo repeat	329..367	CDD:293788	9/37 (24%)
		armadillo repeat	374..409	CDD:293788	10/34 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4208
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H14121
Inparanoid	1	1.050	268	1.000	Inparanoid score	I2956
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D273391at33208
OrthoFinder	1	1.000	-	-		FOG0007267
OrthoInspector	1	1.000	-	-		oto102413
Panther	1	1.100	-	-	LDO	PTHR22895
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8430
SonicParanoid	1	1.000	-	-		X6154
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190