DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nopo and RNF2

DIOPT Version :9

Sequence 1:	NP_611305.1	Gene:	nopo / 37083	FlyBaseID:	FBgn0034314	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_009143.1	Gene:	RNF2 / 6045	HGNCID:	10061	Length:	336	Species:	Homo sapiens

Alignment Length:	273	Identity:	55/273 - (20%)
Similarity:	105/273 - (38%)	Gaps:	60/273 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LNCVICAELFGQADEVFATVCGHMFHHNCLNQWL-DRSKTCPQCRNKCTTRNIFRVYFN----LA 63
            |.|.||.::.  .:.:....|.|.|..:|:...| ..:|.||.||.|..::...|...|    ::
Human    49 LMCPICLDML--KNTMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALIS 111

  Fly    64 NLDVSHIDVGSLQEQLDNAMLSMKMVEKERNKDE-----------QQIRDLKETQKKCLKTIAGL 117
            .:..|..:..:.||::      :..:.|..|:..           |.:..|:..:|:.::..:|.
Human   112 KIYPSRDEYEAHQERV------LARINKHNNQQALSHSIEEGLKIQAMNRLQRGKKQQIENGSGA 170

  Fly   118 EQKVQKKDFLISSYVEQIGVLKSDAHVVDGLRKENKTLKSQIQS---MEGISAILAA-----GSA 174
            |....      ||:..     .:..|........||..|:...|   ::..:|.:|.     |::
Human   171 EDNGD------SSHCS-----NASTHSNQEAGPSNKRTKTSDDSGLELDNNNAAMAIDPVMDGAS 224

  Fly   175 DADRLLKNEADPHVLANWVSTLKRELRQCESKKTE-LRNVVKVVQNDLRKEIELKRKLEERVSHL 238
            :.:.:.:    ||      .||   :.:.:|.:|. ::.......:.|.|.:.::..|||..|..
Human   225 EIELVFR----PH------PTL---MEKDDSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSKG 276

  Fly   239 ES---DLYQAQEK 248
            ||   :|..|.||
Human   277 ESNQMNLDTASEK 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nopo	NP_611305.1	zf-RING_2	5..47	CDD:290367	11/42 (26%)
nopo	NP_611305.1	zf-rbx1	<5..47	CDD:289448	11/42 (26%)
RNF2	NP_009143.1	Interaction with HIP2. /evidence=ECO:0000269\|PubMed:11513855	2..179		29/143 (20%)
		COG5222	<11..>103	CDD:227547	16/55 (29%)
		RING-HC_RING1_like	51..91	CDD:319445	11/41 (27%)
		Interaction with nucleosomes via an acidic patch on histone H2A and histone H2B. /evidence=ECO:0000269\|PubMed:25355358	93..98		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..208		10/61 (16%)
		RAWUL_RING2	225..330	CDD:340687	18/78 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3349
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940