DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nopo and RING1

DIOPT Version :9

Sequence 1:	NP_611305.1	Gene:	nopo / 37083	FlyBaseID:	FBgn0034314	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_002922.2	Gene:	RING1 / 6015	HGNCID:	10018	Length:	406	Species:	Homo sapiens

Alignment Length:	176	Identity:	34/176 - (19%)
Similarity:	69/176 - (39%)	Gaps:	31/176 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 RKEIELKRKL--EERVSHLESDLYQAQEKLQAFENKTAYLDSPNASCGLNSNILALKREERRTTI 284
            ||::..||.|  :.....|.|.:|.::|:.:|.:::.               ::.|.|...:..:
Human    88 RKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRV---------------LIRLSRLHNQQAL 137

  Fly   285 SPTVKENIKRIEESTSPYLNIKSSSVGLAHLLNTKGNIGLAKSKISPIKGVGGGVSMTSGTIRKT 349
            |.:::|.::.  ::......::....|........|..|      .|.:|.|.|..::|.:...:
Human   138 SSSIEEGLRM--QAMHRAQRVRRPIPGSDQTTTMSGGEG------EPGEGEGDGEDVSSDSAPDS 194

  Fly   350 SSDLSEKYSIFKKPRLLLGSSSSSALTATTGSNFVYNGMGGSEKVD 395
            :...:.     |:|| ..|:..||..|...|:..|..|.|..:..|
Human   195 APGPAP-----KRPR-GGGAGGSSVGTGGGGTGGVGGGAGSEDSGD 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nopo	NP_611305.1	zf-RING_2	5..47	CDD:290367
nopo	NP_611305.1	zf-rbx1	<5..47	CDD:289448
RING1	NP_002922.2	Necessary for transcriptional repression. /evidence=ECO:0000250	30..234		33/174 (19%)
		RING-HC_RING1	47..90	CDD:319653	1/1 (100%)
		RING-HC finger (C3HC4-type)	48..87	CDD:319653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..263		20/99 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	201..204		1/2 (50%)
		Necessary for interaction with CBX2. /evidence=ECO:0000250	230..406		1/5 (20%)
		RAWUL	282..400	CDD:318447
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3349
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940