DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10916 and Brca1

DIOPT Version :9

Sequence 1:	NP_001261070.1	Gene:	CG10916 / 37081	FlyBaseID:	FBgn0034312	Length:	263	Species:	Drosophila melanogaster
Sequence 2:	NP_033894.3	Gene:	Brca1 / 12189	MGIID:	104537	Length:	1812	Species:	Mus musculus

Alignment Length:	52	Identity:	15/52 - (28%)
Similarity:	27/52 - (51%)	Gaps:	7/52 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 CAICNEFFRANDIIFSTSRCGHVFHKDCLTRWLNRSR---TCPQCRDPCDRR 80
            |.||.|..:..    .:::|.|:|.|.|:.:.||:.:   .||.|::...:|
Mouse    24 CPICLELIKEP----VSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNEITKR 71

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10916	NP_001261070.1	zf-RING_2	32..74	CDD:290367	13/44 (30%)
		zf-rbx1	<32..74	CDD:289448	13/44 (30%)
		DM9	105..183	CDD:128937
		DUF3421	133..246	CDD:288732
		DM9	186..254	CDD:128937
Brca1	NP_033894.3	rad18	15..>172	CDD:273165	15/52 (29%)
		RING-HC_BRCA1	18..65	CDD:319412	13/44 (30%)
		RING-HC finger (C3HC4-type)	24..64	CDD:319412	13/43 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..362
		BRCT_assoc	342..503	CDD:372330
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..581
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..767
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..899
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1030..1056
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1147..1185
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1205..1230
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1244..1289
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1313..1343
		Interaction with PALB2. /evidence=ECO:0000250	1353..1380
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1437..1547
		BRCT_BRCA1_rpt1	1593..1689	CDD:349367
		BRCT_BRCA1_rpt2	1700..1797	CDD:349353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3349
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030