DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgp-1 and GTPBP2

DIOPT Version :9

Sequence 1:	NP_611302.1	Gene:	Dgp-1 / 37080	FlyBaseID:	FBgn0027836	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_061969.3	Gene:	GTPBP2 / 54676	HGNCID:	4670	Length:	602	Species:	Homo sapiens

Alignment Length:	556	Identity:	260/556 - (46%)
Similarity:	358/556 - (64%)	Gaps:	28/556 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GIKSARSNIFNVDG-------LPQQMAAMSVDYSSIRGKDVLVQPTEEQIELLQKRLQDRIADNC 73
            |.|..:.|..|..|       ||.:....:::|     |..||.|::.:.|.|..:::.|:.:..
Human    38 GPKGKKKNGRNRGGKANNPPYLPPEAEDGNIEY-----KLKLVNPSQYRFEHLVTQMKWRLQEGR 97

  Fly    74 GETIYEIGVGEDGSDSGLNPEQFEASVATLHLLAANIDADVVKLRERRAEKGQS-----AQFLIR 133
            ||.:|:|||.::|...||..|:..||:.|||.:|..:.||:..||||..:....     .:.|:|
Human    98 GEAVYQIGVEDNGLLVGLAEEEMRASLKTLHRMAEKVGADITVLREREVDYDSDMPRKITEVLVR 162

  Fly   134 KHIDTTDFMEIRVAVVGNVDAGKSTLLGVLTHGELDNGRGHARQRLFRHKHEIESGRTSSVGNDI 198
            |..|...|:::||||:||||:||||||||||.||||||||.||..||||.|||:||||||:..:|
Human   163 KVPDNQQFLDLRVAVLGNVDSGKSTLLGVLTQGELDNGRGRARLNLFRHLHEIQSGRTSSISFEI 227

  Fly   199 LGFDGVGNVVNKPDHGHLDWVKICENSAKVITFIDLAGHERYLKTTVFGMTGHAPDFGMLMIGAN 263
            |||:..|.|||..|....:  :|||:|:|:|||||||||.:||.||:||:|.:.||..:|::.||
Human   228 LGFNSKGEVVNYSDSRTAE--EICESSSKMITFIDLAGHHKYLHTTIFGLTSYCPDCALLLVSAN 290

  Fly   264 AGIIGMTKEHLGLALALAVPVFVVVTKIDMCPANVLQENMKLLFKMLKSQGCRKVPVVVRSHDDV 328
            .||.|.|:|||||||||.||.|:||:|||:|....::..::.|.::||..||.|||::|.|.||.
Human   291 TGIAGTTREHLGLALALKVPFFIVVSKIDLCAKTTVERTVRQLERVLKQPGCHKVPMLVTSEDDA 355

  Fly   329 VLSATNFV-SERLCPIFQVSNVTGDNLELLKMFLNLLS--TRMPGSESLP---AEFQIDDVYAVP 387
            |.:|..|. |..:.|||.:|:|:|::|:|||:|||:|.  |.....|.|.   .|||:|::|.||
Human   356 VTAAQQFAQSPNVTPIFTLSSVSGESLDLLKVFLNILPPLTNSKEQEELMQQLTEFQVDEIYTVP 420

  Fly   388 GVGTVVSGTCLQGTIRLNDCLMLGPDAVGSFVPITIKSIHRKRMNVARVRCGQTASFALKKIKRA 452
            .|||||.||...|..|..|.|::||...|.|:.:.:.||.|.|.....:|.||.|:.||....||
Human   421 EVGTVVGGTLSSGICREGDQLVVGPTDDGCFLELRVCSIQRNRSACRVLRAGQAATLALGDFDRA 485

  Fly   453 YLRKGMVMVSQDLKPQACWEFEGEILVLHHPTTISARYQAMVHCGSIRQTASI--IHMSRDCLRT 515
            .|||||||||.::.|..|..||.||::|.|.||....:|..||.|::||||.:  || ::|.|||
Human   486 LLRKGMVMVSPEMNPTICSVFEAEIVLLFHATTFRRGFQVTVHVGNVRQTAVVEKIH-AKDKLRT 549

  Fly   516 GDKAHVKFRFIKQPEYIRAGQRLVFREGRTKAVGNI 551
            |:||.|:|||:|.|||::.|.:|:||||.||.:|::
Human   550 GEKAVVRFRFLKHPEYLKVGAKLLFREGVTKGIGHV 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgp-1	NP_611302.1	GTPBP1	38..555	CDD:227583	253/527 (48%)
		GTPBP1_like	145..367	CDD:206728	128/224 (57%)
		GTPBP_II	376..462	CDD:293895	41/85 (48%)
		GTPBP_III	468..553	CDD:294007	43/86 (50%)
GTPBP2	NP_061969.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..64		7/25 (28%)
GTPBP2	NP_061969.3	GTPBP1	59..588	CDD:227583	255/535 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62195
OrthoDB	1	1.010	-	-		D305827at33208
OrthoFinder	1	1.000	-	-		FOG0002013
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100969
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730