DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgp-1 and CG2017

DIOPT Version :9

Sequence 1:	NP_611302.1	Gene:	Dgp-1 / 37080	FlyBaseID:	FBgn0027836	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_649603.3	Gene:	CG2017 / 40733	FlyBaseID:	FBgn0037391	Length:	643	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	231/568 - (40%)
Similarity:	335/568 - (58%)	Gaps:	33/568 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NGVAVGVGIKSARSNI---FNVDGLPQQMAAMSVDYSSIRGKDVLVQPTEEQIELLQKRLQDRIA 70
            |..:|..|:.:.|.|:   |....||.:....:|:|     |..||.|::::.|.|..:::.|:.
  Fly    82 NECSVVSGMPTERGNLIFDFEQGMLPPEPQLGNVEY-----KLKLVNPSKQRFEHLVTQMKWRLR 141

  Fly    71 DNCGETIYEIGVGEDGSDSGLNPEQFEASVATLHLLAANIDADVVKLRERR-AEKGQSAQFLIRK 134
            :..||.||||||.:.|...||:.:...||:.||..:|.::.|....||.:. |.:...|:.|:||
  Fly   142 EGNGEAIYEIGVSDAGYLQGLSDKDMNASLTTLKQMAHSLGASTSVLRRKTIAARRAVAEVLVRK 206

  Fly   135 HIDTTDFMEIRVAVVGNVDAGKSTLLGVLTHGELDNGRGHARQRLFRHKHEIESGRTSSVGNDIL 199
            ..|....:|:||||:|..||||||||||||..|||||.|.||..:|||.|||:|||||.:.::.|
  Fly   207 IPDDQHNIEVRVAVLGGADAGKSTLLGVLTQDELDNGHGRARLNMFRHMHEIQSGRTSCISHETL 271

  Fly   200 GFDGVGNVVNKPDHGHLDWVKICENSAKVITFIDLAGHERYLKTTVFGMTGHAPDFGMLMIGANA 264
            |||.:|||||...:..:...:|.:.|:|::||:|||||.||::|||..::|::|.:.||::.|.:
  Fly   272 GFDALGNVVNYKYNEMMTAEEISDRSSKLVTFMDLAGHRRYMRTTVQALSGYSPHYAMLVVSAGS 336

  Fly   265 GIIGMTKEHLGLALALAVPVFVVVTKIDM-CPANVLQENMKLLFKMLKSQGCRKVPVVVRSHDDV 328
            |....|:|||.:..||.:|.||:|||.|: .|...:||    |..:|.:.||||||.||.:.|:.
  Fly   337 GCNDTTEEHLAIVRALDMPFFVLVTKTDITSPDATVQE----LCNLLTTIGCRKVPFVVTNTDEA 397

  Fly   329 VLSATNFVSERLCPIFQVSNVTGDNLELLKMFLNLLSTRMPG--------SESLPAEFQIDDVYA 385
            :.:.:|.:||.:.|||.||||||..|.|:..||.:||   ||        .|....|||:|:::.
  Fly   398 ISAGSNQISENIVPIFCVSNVTGTGLNLVTKFLYVLS---PGISNAEKDRLEQESCEFQVDEIFR 459

  Fly   386 VPGVGTVVSGTCLQGTIRLNDCLMLGPDAVGSFVPITIKSIHRKRMNVARVRCGQTASFALKKIK 450
            |..||.||.|..:||.:..|..:.:||...|||.|:|:.:|||.:.....||.||:||.:....:
  Fly   460 VSDVGPVVGGLLVQGVLTENMAMKIGPLPDGSFHPVTVNTIHRNKAPCRVVRAGQSASLSFSMDQ 524

  Fly   451 RA-YLRKGMVMVSQDL-----KPQACWEFEGEILVLHHPTTISARYQAMVHCGSIRQTASIIH-M 508
            .. .||.|||::. |:     :|...:.|:.::.||.|.|.|...:|..||.|||||||.|.. |
  Fly   525 DVPTLRSGMVLLG-DIGNSLDEPYGTFFFQAKVSVLFHATAIYVGFQTTVHIGSIRQTAVIRGIM 588

  Fly   509 SRDCLRTGDKAHVKFRFIKQPEYIRAGQRLVFREGRTKAVGNILRPLP 556
            ..:.|.|.|.|.|.|.|:..|||:|.|.|::||||.:|.:|.:.:..|
  Fly   589 GGERLGTNDCASVMFEFVGHPEYVRPGMRILFREGTSKGIGVVTQVFP 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgp-1	NP_611302.1	GTPBP1	38..555	CDD:227583	222/533 (42%)
		GTPBP1_like	145..367	CDD:206728	111/222 (50%)
		GTPBP_II	376..462	CDD:293895	34/86 (40%)
		GTPBP_III	468..553	CDD:294007	37/85 (44%)
CG2017	NP_649603.3	GTPBP1	100..635	CDD:227583	225/547 (41%)
		GTPBP1_like	217..436	CDD:206728	111/225 (49%)
		GTPBP_II	450..536	CDD:293895	34/85 (40%)
		GTPBP_III	547..634	CDD:294007	37/86 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464643
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5258
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305827at33208
OrthoFinder	1	1.000	-	-		FOG0002013
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100969
Panther	1	1.100	-	-	P	PTHR43721
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840