DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgp-1 and cgp-1

DIOPT Version :9

Sequence 1:	NP_611302.1	Gene:	Dgp-1 / 37080	FlyBaseID:	FBgn0027836	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_503137.1	Gene:	cgp-1 / 178540	WormBaseID:	WBGene00000480	Length:	613	Species:	Caenorhabditis elegans

Alignment Length:	575	Identity:	313/575 - (54%)
Similarity:	401/575 - (69%)	Gaps:	26/575 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 RGKDV--LVQPTEEQIELLQKRLQDRIADNCGETIYEIGV----GEDGSDSGLNPEQFE-ASVAT 102
            ||.|.  |::.|.|.:|.....::.::.:..||.:.|:|.    ......|||:.|..: |:.|.
Worm    33 RGLDAQFLLRSTPEDVEKYMIHVRKQLMEGEGECLVELGAPINSNSKNPKSGLSEEDLDKAADAQ 97

  Fly   103 LHLLAANIDADVVKLRERRAEKGQS---AQFLIRKHIDTTDFMEIRVAVVGNVDAGKSTLLGVLT 164
            |.:| ..|.|...|:..|:...|.|   ..::||......||:|.||||||||||||||||||||
Worm    98 LKIL-EKIPAVGTKVIRRKQTGGGSLFTEVWIIRDPPTEKDFIEARVAVVGNVDAGKSTLLGVLT 161

  Fly   165 HGELDNGRGHARQRLFRHKHEIESGRTSSVGNDILGFDGVGNVVNKPD-HGH-LDWVKICENSAK 227
            |..||:|||.||.:|||||||.||||||||||||||||..||:||||| |.| ||||:|..:.||
Worm   162 HSALDDGRGAARTKLFRHKHEFESGRTSSVGNDILGFDVHGNIVNKPDPHNHNLDWVQIGSDCAK 226

  Fly   228 VITFIDLAGHERYLKTTVFGMTGHAPDFGMLMIGANAGIIGMTKEHLGLALALAVPVFVVVTKID 292
            ::|||||||||:|||||:||||||.||:.|||||||.||||.|||||.|||:|.|||::||||||
Worm   227 LVTFIDLAGHEKYLKTTIFGMTGHMPDYTMLMIGANMGIIGTTKEHLSLALSLHVPVYLVVTKID 291

  Fly   293 MCPANVLQENMKLLFKMLKSQGCRKVPVVVRSHDDVVLSATNFVSERLCPIFQVSNVTGDNLELL 357
            |||||:|:|.||.:.::::|  .:|:|::||:.||||.:|.||.|:::|||||||||.|.||.||
Worm   292 MCPANILEETMKNITRLVRS--AKKLPILVRNMDDVVHAAVNFPSKKVCPIFQVSNVEGTNLPLL 354

  Fly   358 KMFLNLLSTRMPGSESLPAEFQIDDVYAVPGVGTVVSGTCLQGTIRLNDCLMLGPDAVGSFVPIT 422
            :.|||::..|...:|:.||.|||||:|.|.||||:.|||.|.|||||||.|:|||.:.|.|:||.
Worm   355 RQFLNIVPLRRQLNENDPAHFQIDDIYWVDGVGTIASGTLLSGTIRLNDILLLGPTSNGDFMPIP 419

  Fly   423 IKSIHRKRMNVARVRCGQTASFALKKIKRAYLRKGMVMVSQDLKPQACWEFEGEILVLHHPTTIS 487
            |||||||||.|..|:|||:||||||||.:..:|||||:|...:||.|...||.|||||||||||.
Worm   420 IKSIHRKRMPVGIVKCGQSASFALKKIPKKDVRKGMVLVDPKVKPVASMVFEAEILVLHHPTTIK 484

  Fly   488 ARYQAMVHCGSIRQTASIIHMSRDCLRTGDKAHVKFRFIKQPEYIRAGQRLVFREGRTKAVGNIL 552
            ..||||:|.||:||||:::.|.::.|||||:..|:|:||:||||||.|.::|||||||||||.:.
Worm   485 PNYQAMLHIGSVRQTATLVSMGKEVLRTGDRDKVQFKFIRQPEYIRPGTKMVFREGRTKAVGTVS 549

  Fly   553 RPLPNAAASPYRPKPAKMQSRSHNGGSNGSNNQHRQQGQGSSSGAGCSKDNADEK 607
            ..:|..:.:..|.|.           .:|...|:.::..|.....|..|:..::|
Worm   550 SVVPQESLAQQRAKQ-----------KDGRQKQYGKKSMGPKPPNGKPKEKIEKK 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgp-1	NP_611302.1	GTPBP1	38..555	CDD:227583	304/521 (58%)
		GTPBP1_like	145..367	CDD:206728	157/223 (70%)
		GTPBP_II	376..462	CDD:293895	58/85 (68%)
		GTPBP_III	468..553	CDD:294007	53/84 (63%)
cgp-1	NP_503137.1	GTPBP1	44..552	CDD:227583	300/510 (59%)
		GTPBP1_like	142..364	CDD:206728	157/223 (70%)
		GTPBP_II	373..459	CDD:293895	58/85 (68%)
		GTPBP_III	465..551	CDD:294007	53/85 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167089
Domainoid	1	1.000	314	1.000	Domainoid score	I699
eggNOG	1	0.900	-	-		E1_COG5258
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3165
Inparanoid	1	1.050	574	1.000	Inparanoid score	I564
Isobase	1	0.950	-	0	Normalized mean entropy	S1965
OMA	1	1.010	-	-		QHG62195
OrthoDB	1	1.010	-	-		D305827at33208
OrthoFinder	1	1.000	-	-		FOG0002013
OrthoInspector	1	1.000	-	-		oto19660
orthoMCL	1	0.900	-	-		OOG6_100969
Panther	1	1.100	-	-	LDO	PTHR43721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2451
SonicParanoid	1	1.000	-	-		X4471
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790